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Composition of hydrophilic polymer

A technology of hydrophilic polymers and polymers, applied in the direction of active ingredients of heterocyclic compounds, drug delivery, plant raw materials, etc., can solve problems not mentioned

Pending Publication Date: 2018-04-20
钟术光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The patent also does not mention partially pregelatinized ( / ) starch, in the examples it mentions drum dried waxy corn starch

Method used

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  • Composition of hydrophilic polymer

Examples

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Effect test

Embodiment 1

[0187] Formula (1000 tablets): 200g of levofloxacin hydrochloride, 40g of microcrystalline cellulose, 50g of croscarmellose sodium, 10g of sodium polyacrylate, 10g of povidone (K30), 5g of magnesium stearate, and 5g of micronized silica gel.

Embodiment 2

[0194] Formula (1 tablet): Acyclovir (200mg) 40%, lactose 21.5%, microcrystalline cellulose 24%, sodium carboxymethyl starch 10%, sodium polyhydroxyethylacrylate 2%, polyvinylpyrrolidone 0.5%, Magnesium Stearate 1% and Micronized Silica Gel 1%.

Embodiment 3

[0201] Formula (1000 tablets): Telmisartan 10.0g, starch 52.0g, lactose 30.0g, cross-linked polyvinylpyrrolidone plus 16.0g plus 4g, polylysine hydrochloride 10.0g, micropowder silica gel 3.0g, stearin Magnesium acid 1.0g.

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Abstract

The present invention discloses a composition of a hydrogel type polymer with improved disintegration performance, wherein the composition contains one (or a variety of) hydrophilic polymer I and a hydrophilic polymer II with 1.5 times or more the AAP value of the hydrophilic polymer I. The invention further discloses a preparation (with improved drug release property (stability), especially a hydrophilic slow-release ( / controlled-release) preparation), which contains one (or a variety of) drug, the composition of the hydrogel type polymer, and an optionally pharmaceutically acceptable formulaagent. According to the present invention, the damage on the drug release (especially slow-release ( / controlled release)) from the preparation by the ion intensity (salinity) of the release medium isneutralized, such that the complete-dose preparation release under the eating condition or the substantially no release under the fasting condition along the whole gastrointestinal tract can be prevented in the release medium with the changed ion intensity or the high-salinity.

Description

technical field [0001] The present invention relates to a composition of hydrophilic polymers. Specifically, it relates to a composition of hydrophilic polymers with improved disintegration (or swelling) properties. technical background [0002] Pharmaceutical hydrophilic polymers can be used as disintegrants or blockers in medicine to accelerate or delay drug release to achieve the desired purpose. Its principle is to achieve the goal through the formation of swollen substances by the pharmaceutical hydrophilic polymer. [0003] However, these hydrophilic polymers that are swellable in contact with water as "disintegrants" or "blockers" are prone to "salt poisoning" effects and "gel blocking" effects, especially under pressure ( That is, when it expands, it will be reacted by the "four walls" of other surrounding matrix materials). The "salt poisoning" effect here (same meaning below) refers to the swellable hydrophilic polymer in contact with water, especially under pre...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K47/32A61K47/36A61K47/26A61K47/10A61K9/22A61K9/16A61K9/52A61K9/70A61K31/5383A61K31/522A61K31/4184A61K31/277A61K31/41A61K31/4709A61K31/198A61K31/4015A61K31/138A61K36/734A61K31/135A61K31/7036A61K31/4985A61K31/541A61K31/27A61K31/4468A61K31/7048A61K31/192A61K31/137A61K31/554A61K31/4748
CPCA61K9/0002A61K9/1652A61K9/2018A61K9/2027A61K9/2045A61K9/2054A61K9/2059A61K9/4866A61K9/7007A61K31/135A61K31/137A61K31/138A61K31/192A61K31/196A61K31/198A61K31/24A61K31/27A61K31/277A61K31/352A61K31/4015A61K31/41A61K31/4184A61K31/4422A61K31/4468A61K31/4709A61K31/4748A61K31/48A61K31/496A61K31/4985A61K31/517A61K31/522A61K31/5383A61K31/541A61K31/554A61K31/7034A61K31/7036A61K31/7048A61K36/734A61K47/36A61K47/38
Inventor 钟术光
Owner 钟术光
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