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Preparation method of oral liquid for treating diabetes

An oral liquid and diabetes technology, applied in the field of health care, can solve the problems of liver and kidney function damage, tolerance and other problems, and achieve the effects of resisting oxidative damage, maintaining ion stability, and enhancing biological activity

Inactive Publication Date: 2018-04-20
蒋文明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a preparation method of an oral liquid for treating diabetes in view of the problem that although the current medicine has a relatively good effect of lowering blood sugar, long-term use will cause damage to liver and kidney functions and produce tolerance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] A preparation method for an oral liquid for treating diabetes, comprising the steps of:

[0025] (1) Add Lactobacillus reuteri and Saccharomyces cerevisiae to physiological saline at a mass ratio of 1:2:10, shake well, and dilute the mixed bacterial suspension to 10 -5 For the dilution level, take the diluted bacterial suspension and inoculate it into the activated medium according to the mass ratio of 1:9, and cultivate it at 28-35°C for 3-5 days to obtain the activated bacterial liquid, and take 10-15 parts by mass. Mix the activated bacteria liquid, 40~50 parts of Ligularia sativa powder, 30~40 parts of Aralia powder, and 80~100 parts of fermentation medium, ferment at 33~37°C for 1~2 days, centrifuge, and take the supernatant to obtain the fermentation liquid ;

[0026] (2) Take the fermentation broth and add anhydrous ether at a mass ratio of 1:100, degrease at 80-85°C for 4-5 hours to obtain a degreased product, take the degreased product at a mass ratio of 1:30,...

Embodiment 1

[0030] Aralia and Aralia: Wash the Aralia and Aralia, dry, crush and pass through an 80-mesh sieve, collect the sieved granules of Aralia and Aralia, and obtain the Aralia powder and Aralia powder.

[0031] Lactic acid bacteria: Lactobacillus reuteri, Saccharomyces cerevisiae, preserved on slant.

[0032] Fermentation medium: in parts by mass, take 10 parts of casein peptone, 8 parts of beef extract, 3 parts of yeast extract, 2 parts of triammonium citrate, 0.8 part of Tween-80, 5 parts of sodium acetate, 2 parts of dihydrogen phosphate Potassium, 0.5 parts magnesium sulfate, 0.05 parts manganese sulfate, 100 parts 15°Brix soybean molasses, pH 6.0, sterilized at 121°C for 15 min.

[0033] A preparation method for an oral liquid for treating diabetes, comprising the steps of:

[0034] (1) Add Lactobacillus reuteri and Saccharomyces cerevisiae to physiological saline at a mass ratio of 1:2:10, shake well, and dilute the mixed bacterial suspension to 10 -5 For the dilution level,...

Embodiment 2

[0039] Aralia and Aralia: Wash the Aralia and Aralia, dry, crush and pass through an 80-mesh sieve, collect the sieved granules of Aralia and Aralia, and obtain the Aralia powder and Aralia powder.

[0040] Lactic acid bacteria: Lactobacillus reuteri, Saccharomyces cerevisiae, preserved on slant.

[0041] Fermentation medium: in parts by mass, take 12 parts of casein peptone, 10 parts of beef extract, 4 parts of yeast extract, 2 parts of triammonium citrate, 1.0 part of Tween-80, 6 parts of sodium acetate, 2 parts of dihydrogen phosphate Potassium, 0.6 parts magnesium sulfate, 0.07 parts manganese sulfate, 100 parts 15°Brix soybean molasses, pH 6.1, sterilized at 121°C for 15 min.

[0042] A preparation method for an oral liquid for treating diabetes, comprising the steps of:

[0043] (1) Add Lactobacillus reuteri and Saccharomyces cerevisiae to physiological saline at a mass ratio of 1:2:10, shake well, and dilute the mixed bacterial suspension to 10 -5 For the dilution lev...

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Abstract

The invention relates to the technical field of health caring, in particular to a preparation method of oral liquid for treating diabetes. Firstly, ligularia intermedia and Chinese aralis are cleanlycleaned; polysaccharide substances and total saponin substances in the ligularia intermedia and the Chinese aralis can effectively prevent the continuous rise of the plasma glucose level; the ultra microstructure of the kidney is maintained; the substrate membrane thickening is avoided, so that the filtration function of the glomerulus is normal; through the joint fermentation of lactobacilli andsaccharomycetes, ingredients for maintaining the blood glucose are converted into beneficial substances capable of being easily digested and absorbed by the human body; the molecular weight of the effective medicine ingredients is reduced; new microbial metabolism secondary products and other probiotics are generated; under the condition of co-existence of the saccharomycetes and the lactobacilli,lactic acid is converted into lactose; the lactose is decomposed to be converted into galactose; the synergistic effect is achieved; the content of ingredients, with the blood glucose reduction effect, in the fermented ligularia intermedia and Chinese aralis is improved; the diabetes is better treated in an auxiliary way.

Description

technical field [0001] The invention relates to the technical field of health care, in particular to a preparation method of an oral liquid for treating diabetes. Background technique [0002] Diabetes mellitus is a common endocrine and metabolic disease that can cause chronic complications in multiple systems and organs such as the heart, eyes, peripheral blood vessels, and nerves. The prevalence rate in developed countries is about 6%, and it has become the third largest disease after malignant tumors and cardiovascular diseases. At present, although various drugs are clinically used to treat diabetes, most of them are incomplete, such as drug resistance and side effects. [0003] Diabetes is a metabolic disease with multiple etiologies, characterized by chronic hyperglycemia, accompanied by disorders of carbohydrate, fat and protein metabolism caused by defects in insulin secretion or action. When the human body lacks insulin or insulin cannot function effectively, blood...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/08A61P3/10
CPCA61K9/0053A61K36/25A61K36/28A61K2236/19A61K2236/331A61K2236/333A61K2236/35A61K2236/51A61K2236/53A61K2300/00
Inventor 蒋文明郑薇林凡
Owner 蒋文明
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