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Preparation method of compound cerebroprotein hydrolysate tablets

A cerebroprotein hydrolyzate and compound technology, which is applied in the field of preparation of compound cerebroprotein hydrolyzate tablets, can solve the problems of affecting the curative effect and low bioavailability of oral preparations, and achieve good curative effect, good adsorption load performance, and good dispersibility Effect

Inactive Publication Date: 2018-03-23
安徽金太阳生化药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used dosage forms of cerebroprotein hydrolyzate preparations mainly include injections, oral tablets, etc., among which oral tablets are film-coated tablets. Tablets, coating, packaging and other steps, although the obtained product has the advantages of convenient carrying and taking, easy storage, etc., but because amino acids and polypeptides are easily affected by the preparation process and the gastrointestinal environment after taking Live, resulting in low bioavailability of oral preparations of cerebroprotein hydrolyzate, affecting the curative effect

Method used

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Embodiment Construction

[0017] A preparation method of compound cerebroprotein hydrolyzate sheet, comprising the following steps:

[0018] (1) Add 180kg of cerebroprotein hydrolyzate to the phosphate buffer solution with a concentration of 0.01mol / L to fully dissolve, prepare a cerebroprotein hydrolyzate solution with a mass fraction of 3%, and then add 0.5 times the weight of cerebroprotein hydrolyzate The hydroxyapatite microspheres were shaken and adsorbed at 20°C for 4 hours, and the cerebroprotein hydrolyzate micropowder was obtained after freeze-drying;

[0019] (2) Combine the cerebroprotein hydrolyzate micropowder obtained in step (1) with 20kg sodium chondroitin sulfate, 20kg glutamic acid, 35kg microcrystalline cellulose, 1kg vitamin B1, 0.5kg vitamin B6, 21kg dextrin, 25.5kg calcium carbonate 1. Add 30kg of cornstarch into the fluidized granulation dryer, turn on the induced draft, and spray 100kg of ethanol with a concentration of 50% at a uniform speed for spray granulation and drying. A...

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Abstract

The invention discloses a preparation method of compound cerebroprotein hydrolysate tablets. The preparation method includes: adding hydroxyapatite microspheres into a cerebroprotein hydrolysate solution for oscillating adsorption; freeze-drying, and loading part of cerebroprotein hydrolysate onto the hydroxyapatite microspheres to obtain cerebroprotein hydrolysate micropowder; mixing with auxiliary materials like sodium chondroitin sulfate, glutamic acid and microcrystalline cellulose, spraying, granulating, and drying to obtain cerebroprotein hydrolysate granules; tabletting, using a coatingmaterial for coating to obtain compound cerebroprotein hydrolysate tablets. By the preparation method, drug absorption can be promoted, and drug deactivation can be reduced, so that bioavailability of a cerebroprotein hydrolysate oral preparation is improved to realize good treatment effect.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a method for preparing compound cerebroprotein hydrolyzate tablets. Background technique [0002] Cerebroprotein hydrolyzate is an aqueous solution of a mixture of various amino acids and low-molecular-weight peptides obtained by enzymatic hydrolysis of animal brain tissue proteins. It is a unique peptide energy neurotrophic drug for the brain, which can act on the central nervous system in various ways to regulate And improve the metabolism of neurons, promote the formation of synapses, induce the differentiation of neurons, and further protect nerve cells from various ischemia and neurotoxin damage. It is used to improve symptoms such as insomnia, headache, memory loss, dizziness and irritability, and can promote the rehabilitation of sequelae of brain trauma, sequelae of cerebrovascular diseases, sequelae of encephalitis, acute cerebral infarction and acute...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K9/40A61K47/02A61K47/44A61K47/42A61K47/38A61K47/36A61P25/00
CPCA61K9/2009A61K9/2054A61K9/2059A61K9/282A61K9/2873A61K38/012
Inventor 张强张金全李安
Owner 安徽金太阳生化药业有限公司
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