Antibacterial surgical suture without being taken out and preparation method thereof

A surgical suturing, removal-free technology, applied in surgery, medical science, surgical instruments, etc., can solve the problems of increasing the difficulty of postoperative care of patients, achieve good biocompatibility, reduce the incidence rate, and reduce the effect of rejection

Active Publication Date: 2018-03-20
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantages are: the degradation product is acidic, causing different degrees of swelling at the site of application, resulting in the phenomenon of "aseptic effusion", that is, a non-specific aseptic inflammation phenomenon, and the swelling needs to be discharged in time to eliminate the swelling , increasing the difficulty of postoperative care for patients and delaying the speed of wound healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A dismantling-free antibacterial surgical suture, consisting of the following components in parts by weight: 80 parts of polycaprolactone resin, 5 parts of sodium carboxymethylcellulose, 5 parts of polyvinyl alcohol, 5 parts of glycerin, 5 parts of calcium carbonate, and 5 parts of starch 15 parts of aloe vera powder, 10 parts of polylactic acid, 3 parts of chitosan, 5 parts of silk fibroin, 5 parts of agar, and 5 parts of Artemisia argyi leaf extract. Weigh the above powder raw materials by weight and mix them uniformly in a high-speed mixer, then blend them with glycerin and ultrasonically grind them for 1 hour at a grinding speed of 200rpm, and feed the mixture into a twin-screw extruder from the main feeding port for Melt blending extrusion processing, the main processing temperature of the twin-screw extruder is 120°C, after stretching, water cooling, pelletizing, and low-temperature drying to obtain plastic masterbatches, the plastic masterbatches are diluted and t...

Embodiment 2

[0023] A dismantling-free antibacterial surgical suture, consisting of the following components in parts by weight: 90 parts of polycaprolactone resin, 8 parts of sodium carboxymethylcellulose, 8 parts of polyvinyl alcohol, 9 parts of glycerin, 6 parts of calcium carbonate, and 20 parts of starch 10 parts of aloe vera powder, 15 parts of polylactic acid, 5 parts of chitosan, 8 parts of silk fibroin, 3 parts of agar, 3 parts of Artemisia argyi leaf extract. Weigh the above powder raw materials by weight and mix them uniformly in a high-speed mixer, then blend them with glycerin and ultrasonically grind them for 3 hours at a grinding speed of 200rpm, and feed the mixture into a twin-screw extruder from the main feeding port for melting Blending extrusion processing, the main processing temperature of the twin-screw extruder is 125°C, after stretching, water cooling, pelletizing, and low-temperature drying to obtain plastic masterbatches, the plastic masterbatches are diluted and ...

Embodiment 3

[0025] A dismantling-free antibacterial surgical suture, consisting of the following components in parts by weight: 95 parts of polycaprolactone resin, 3 parts of sodium carboxymethylcellulose, 3 parts of polyvinyl alcohol, 4 parts of glycerin, 3 parts of calcium carbonate, and 30 parts of starch 20 parts of aloe vera powder, 12 parts of polylactic acid, 9 parts of chitosan, 6 parts of silk fibroin, 10 parts of agar, and 8 parts of Artemisia argyi leaf extract. Weigh the above powder raw materials by weight and mix them uniformly in a high-speed mixer, then blend them with glycerin and ultrasonically grind them for 5 hours at a grinding speed of 200rpm, and feed the mixture into a twin-screw extruder from the main feeding port for melting Blending extrusion processing, the main processing temperature of the twin-screw extruder is 130°C, after stretching, water cooling, pelletizing, and low-temperature drying to obtain plastic masterbatches, the plastic masterbatches are diluted...

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PUM

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Abstract

The invention discloses an antibacterial surgical suture without being taken out and a preparation method thereof. The surgical suture is prepared from the following ingredients in parts by weight: 80to 100 parts of matrix resin, 1 to 10 parts of sodium carboxymethylcellulose, 1 to 10 parts of polyvinyl alcohol, 1 to 10 parts of glycerinum, 1 to 10 parts of calcium carbonate, 1 to 30 parts of starch, 1 to 10 parts of chitosan, 1 to 10 parts of silk fibroin, 1 to 10 parts of agar and 1 to 20 parts of aloe powder. The antibacterial surgical suture without being taken out disclosed by the invention has good biocompatibility, cells can normally grow on a base frame of the surgical suture, the surgical suture can be completely decomposed into water and carbon dioxide, secondary pain caused bytaking the suture out is avoided, and the surgical suture has antibacterial and anti-inflammation effects, can reduce an occurrence rate of postoperation wound infection and can promote wound healing.

Description

technical field [0001] The invention relates to the technical field of polymer composite materials. In particular, it relates to a dismantling-free antibacterial surgical suture and a preparation method thereof. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suturing, hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. The former has the characteristics of high tensile strength, easy disinfection and sterilization, and low tissue reaction, but it cannot be degraded in the body, so it needs to be removed after suturing, which is easy to cause secondary pain, infection, and scars; the latter can be degraded in the body. Soluble products are absorbed by the body and gradually excreted out of the body, thereby reducing the suffering of patients. The ideal absorbable suture material in clinical application sh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/00
CPCA61L17/005A61L17/10A61L17/105A61L2300/30A61L2300/404A61L2300/41A61L2300/412C08L67/04C08L1/286C08L29/04C08L3/02C08L5/08C08L89/00C08L5/12
Inventor 何丹农王岩岩林琳陈超
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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