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A kind of strontium-containing biological material and its preparation method and application

A biomaterial and composite biomaterial technology, applied in the field of biomaterials, can solve the problems of poor cell ALP activity, changing the chemical stability of materials, and poor cell osteogenic differentiation ability.

Active Publication Date: 2021-04-23
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently researched strontium-containing materials are mainly obtained by replacing the Ca element in the material with Sr, such as patent CN104436295A, this method of introducing Sr belongs to adding it to silicate by doping, and doping will change the content of the doped The lattice of heteroceramic materials, the addition of this Sr may affect the release of other elements (such as silicate and Zn ions, etc.), changing the chemical stability of the entire material
In addition, the current biomaterial with Sr doped in a doped manner is poor in cellular ALP activity, indicating its poor ability to promote osteogenic differentiation of cells

Method used

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  • A kind of strontium-containing biological material and its preparation method and application
  • A kind of strontium-containing biological material and its preparation method and application
  • A kind of strontium-containing biological material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: high temperature solid state method prepares Sr 2 ZnSi 2 o 7

[0051] SiO 2 :ZnO:SrCO 3 Weigh according to molar ratio 2:1:2, mix into powder, place in agate jar, add agate ball and alcohol respectively according to powder: agate ball: alcohol mass ratio of 1:1.5:1, and the proportion of agate ball is the largest (10mm diameter): medium (8mm diameter): small (5mm diameter) is equal to 2:2:1, ball milling in a planetary ball mill at 300r / min for 4h;

[0052] The ball-milled powder was dried in an oven at 120°C, and then calcined in a muffle furnace at 1250°C for 4 hours;

[0053] Continue to ball mill the sintered powder at 300r / min for 4 hours; dry the ball milled powder in an oven at 120°C, and pass through a 200-mesh sieve to obtain Sr 2 ZnSi 2 o 7 , see the preparation flow chart figure 2 A in

[0054] The prepared Sr 2 ZnSi 2 o 7 Carry out X-ray diffraction, the result shows that it is a tetragonal crystal system, see figure 1 A in, and ...

Embodiment 2

[0055] Example 2: Preparation of SrZrSi by high-temperature solid-phase method 2 o 7

[0056] Weigh SiO2:ZrO2:SrCO3 at a molar ratio of 2:1:1, mix it into powder, place it in an agate jar, add agate balls and alcohol respectively according to the mass ratio of powder: agate ball:alcohol at 1:1.5:1, wherein The proportion of balls is large: medium: small equal to 2:2:1, and the ball is milled in a planetary ball mill at 300r / min for 4h;

[0057] The ball-milled powder was dried in an oven at 120°C, and then calcined in a muffle furnace at 1280°C for 10 hours;

[0058] Continue to ball mill the sintered powder at 300r / min for 4 hours; dry the ball milled powder in an oven at 120°C, and pass through a 200-mesh sieve to obtain SrZrSi 2 o 7 , see the preparation flow chart figure 2 D in

[0059] The prepared SrZrSi 2 o 7 Carry out X-ray diffraction, the result shows that it is monoclinic, see figure 1 B in, and X-ray diffraction results are consistent with SrZrSi 2 o 7 Th...

Embodiment 3

[0060] Embodiment 3: sol-gel prepares Sr 2 ZnSi 2 o 7

[0061] Mix tetraethyl orthosilicate (TEOS) with water at a molar ratio of 1:(5-8), adjust the pH to 2-4 with nitric acid, and stir thoroughly at room temperature for 30 minutes; add zinc nitrate tetrahydrate and strontium nitrate, in which Sr(NO 3 ) 2 :Zn(NO 3 ) 2 : The molar ratio of TEOS is 2:1:2, magnetic stirring for 3-5h;

[0062] Airtight aging at room temperature overnight to form a sol; heat the sol in an oven at 120°C for 48 hours to form a xerogel; place the xerogel in a muffle furnace for calcination at 1100-1300°C for 3-5 hours; sieve the calcined powder , get Sr 2 ZnSi 2 o 7 , see the preparation flow chart figure 2 B in

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Abstract

The invention relates to the technical field of biomaterials, and discloses a strontium-containing biomaterial, a preparation method and application thereof. The general chemical composition formula of the strontium-containing biological material of the present invention is Sr X DSi 2 o 7 , wherein the X is 1 or 2, and the D is selected from Zn or Zr. The present invention synthesizes a biologically active silicate biomaterial containing Sr, Zn or Zr in a non-doping manner, has a single crystal structure, and the material has excellent mechanical properties, biocompatibility and osteoinductive ability , can be used as artificial joint coating to improve the osteoinductive ability of current metal implants, ensure the long-term stability of implants, and can also be prepared into three-dimensional porous bone repair scaffolds to repair bone damage.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a strontium-containing biomaterial and its preparation method and application. Background technique [0002] Bone tissue defect and injury has become an important disease that affects people's health and life, and the repair and reconstruction of bone damage is a difficult clinical problem at present. The best solution for bone defect repair is autologous bone grafting, but this method is a method of healing from injury; allogeneic bone also has good osteoinductive ability, but it is easy to cause immune rejection after allogeneic bone is implanted into the human body. In addition, both allogeneic bone and autologous bone have the disadvantages of limited sources. With the development of artificial bone repair materials, it has become possible to use bioactive materials to repair bone defects. The preparation of new artificial bone repair materials with high osteoinductive ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/06A61L27/50A61L27/56C23C4/134C23C4/11C01B33/20
CPCA61L27/06A61L27/306A61L27/50A61L27/56A61L2400/18A61L2430/02A61L2430/24C01B33/20C01P2002/72C01P2004/03C23C4/11C23C4/134
Inventor 王国成徐正江唐为
Owner SHENZHEN INST OF ADVANCED TECH
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