Postoperative adhesion-resisting polymer thin film and preparation method thereof

Abstract

The invention provides a preparation method of a postoperative adhesion-resisting polymer thin film. The preparation method comprises the following steps: (A) mixing a biodegradable polymer material, an emulsifying agent and an organic solvent to obtain a polymer solution; mixing glucosan with water to obtain an aqueous phase solution; (B) adding the aqueous phase solution into the polymer solution, and mixing and emulsifying to obtain homogeneous emulsion; (C) carrying out electrostatic spinning on the homogeneous emulsion to obtain an electrostatic spinning fibrous membrane; (D) drying the electrostatic spinning fibrous membrane and then carrying out ultraviolet ozone treatment to obtain the postoperative adhesion-resisting polymer thin film. The postoperative adhesion-resisting polymer thin film provided by the application is excellent in overall property and free of biotoxicity, can be well attached to tissues, and has a better inhibiting effect on fibroblasts and inflammatory factors, thereby effectively isolating the tissues to realize an adhesion-resisting effect.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a postoperative anti-adhesion polymer film and a preparation method thereof. Background technique [0002] Postoperative abdominal adhesions are a common clinical symptom. According to foreign data, the incidence of postoperative abdominal adhesions is as high as 80%. Abdominal adhesion is an inevitable process of postoperative peritoneal repair. There is no repair without adhesions, but when the repair is disordered or the fibers are incompletely degraded to become point-like, angled, and cord-like fibrous bands, serious complications will be brought about, such as intestinal obstruction, infertility, surgery, etc. This makes the patient have to go to the hospital for the second operation, which not only brings pain to the patient but also increases the financial burden. [0003] In recent years, it has become a common practice in the world to prevent postoperative ad...

AI Technical Summary

Problems solved by technology

Sodium hyaluronate is commonly used clinically to prevent postoperative adhesions, but the effect is not satisfactory, especially because of its low purity and no anti-inflammatory effect, so the scope of clinical application is narrow

Absorbable polylactic acid solid materials with a certain strength and shape are usually used abroad to achieve the purpose of isolating wounds and preventing and reducing adhesions, but due to high strength and rigidity, poor flexibility and impact resistance, its anti-adhesion The effect is not ideal

The Chinese patent whose publication number is CN1241442A makes a copolymer of polyglycolic acid and polylactic acid into a film for postoperative anti-adhesion; but the above-mentioned materials not only have limited flexibility, but also have poor degradation controllability, which is not conducive to application

International patent WO2006 / 100895 and Chinese patent CN101052425A disclose a medical film composed of lactide and caprolactone copolymer, which has good flexibility and strength, but the surface properties of the material itself are poor (surface porous), and the adhesion protein in the body And cells are easy to adhere to the surface of the material to cause adhesion, and the degradation rate of the material is slow, and it takes 6 months for complete absorption

Chinese patent CN1436801A discloses a solution polymerization method, which uses toluene and xylene as solvents to prepare poly(D,L-lactic acid)-glycolic acid copolymers; due to the toxicity of the solvents used in the preparation process, it may be harmful to the environment and operation. There is a certain impact on personnel, which limits its application in the field of clinical medicine

However, soluble polyethers will dissolve into body fluids in the body and be lost from the membrane, which cannot inhibit the proliferation of fibroblasts on the membrane surface

In addition, the affinity between the above medical membranes and tissues is difficult to achieve satisfactory results, which brings new problems to the prevention and treatment of adhesions.

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