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Preparing method and application of Pudilan oral liquid

A technology for Pudilan oral liquid and oral liquid, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve the problems of poor taste and low effective ingredients, and reduce the extraction time. , High effective ingredients, the effect of masking the bad smell of drugs

Inactive Publication Date: 2017-07-04
江苏医耐韦德生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Aiming at the problems of low active ingredients and poor taste in the existing pudilan traditional Chinese medicine, the present invention provides a pudilan oral liquid and its preparation method and use, which can effectively cover up the bad smell of the medicine and make it into an oral liquid dosage form

Method used

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  • Preparing method and application of Pudilan oral liquid
  • Preparing method and application of Pudilan oral liquid
  • Preparing method and application of Pudilan oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Study on Extraction Technology of Scutellaria Baicalensis

[0053] Test according to Table 1-1, 1-2, 1-3 test table, compare the optimal extraction process with the peak height and peak area of ​​baicalin in HPLC as indicators.

[0054] 1. Experimental method

[0055] Carry out the test according to the table 1-1, 1-2, 1-3, 1-4 test table, each group is to weigh 10g of Scutellaria baicalensis, add ethanol to reflux extraction, combine the extracts, reclaim ethanol, concentrate, and detect by HPLC, respectively The conditions such as extraction temperature, ethanol concentration used in extraction, extraction alcohol amount, extraction time, pH, gelatin amount, and chitosan amount were compared and optimized.

[0056] 2. Experimental process

[0057] 1. Instruments and reagents: high performance liquid chromatography (Agilent); methanol is chromatographically pure, water is up water, and other reagents are analytically pure.

[0058] 2. Chromatographic c...

Embodiment 2

[0120] Pharmacological Experimental Study on Anti-Inflammation in Mice

[0121] 1. Test materials

[0122] Animals: 24 icr mice, male, weighing about 25g

[0123] Drugs: prepared oral liquid

[0124] 2. Test method

[0125] 24 healthy mice were randomly divided into 3 groups, 8 in each group: blank control, commercially available Pudilan Oral Liquid, and Pudilan Oral Liquid prepared in our laboratory.

[0126] Administration was administered once 6 hours and 1 hour before the formation of the acute inflammation model, and each time the mice in the blank control group and the administration group were administered with 0.21mL / 10g body weight of normal saline and corresponding medicinal solutions.

[0127] 1 hour after the administration of the experimental mice, first measure the thickness of the right auricle of the mouse, and then instill 0.07mL xylene in the right auricle, and use a vernier caliper to measure the ear swelling degree of the mouse every 15 m...

Embodiment 3

[0135] Pudilan Oral Liquid

[0136] Dandelion 100g, Diding 25g, Radix Radix 37.6g, Scutellaria baicalensis 37.6g, sucrose 40g.

[0137] Mix 100g of dandelion and 37.6g of Radix isatidis, add 15 times of water and decoct twice, add 1% gelatin, stir for 1 hour until it is completely dissolved, let stand, and take the supernatant.

[0138] Decoct 25g of Diding with 15 times of water, cool to room temperature, and filter.

[0139] Mix the extracts and , filter, concentrate to a density of 1.1, add chitosan to 0.1%, adjust the pH to 2, let stand, filter, and remove the precipitate.

[0140] Scutellaria baicalensis 37.6g was extracted with 8 times the amount of 50% ethanol, extracted twice at 40°C by ultrasonic, 2 hours each time, the extract was filtered to remove impurities, 1% gelatin was added to the filtrate, stirred for 1 hour, until it was completely dissolved, and static place, filter to get the supernatant, add 2% chitosan to the filtrate, adjust the pH to...

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Abstract

The invention discloses a preparing method and application of a Pudilan oral liquid, and belongs to the technical field of traditional Chinese medicine preparation. The oral liquid is prepared by the steps of extracting and concentrating four Chinese herbal medicines of dandelion, isatis root, herba corydalis bungeanae and radix scutellariae to obtain an extract according to a specific process, is made into an oral liquid preparation suitable for taking, effectively covers the drug bad taste, and solves the drug mouthfeeling problem. The extraction method is improved, so the extraction time is shortened greatly; the content of main effective components is increased significantly, the medicine taking dosage is reduced, and the oral liquid has the efficacies of clearing away heat and toxic materials, resisting inflammation, removing swelling and the like, has high content of the effective ingredients, has little taking dosage, and is used for treatment of parotitis, pharyngitis, amygdalitis or furuncle and other diseases. The Pudilan oral liquid is suitable for children to take.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and more specifically relates to a pudilan oral liquid, its preparation method and application. Background technique [0002] Pudilan is composed of four traditional Chinese medicines: dandelion, isatis root, diding and scutellaria baicalensis. It has the functions of clearing heat and detoxifying, anti-inflammatory and reducing swelling. [0003] Dandelion whole herb contains dandelion sterol, choline, inulin, caffeic acid, pectin, dandelion alcohol, β-mycinol, stigmasterol, β-sitosterol, dandelion cylindrol, dandelion, dandelion bitter and vitamin A, B, C, etc. Among them, the active ingredients of dandelion include caffeic acid and cichoric acid. [0004] Radix Isatidis contains indigo, indirubin, anthraquinones, β-sitosterol, γ-sitosterol and various amino acids: arginine, glutamic acid, tyrosine, proline, valine, γ-aminobutyric acid acid. It also contain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61K9/08A61K47/26A61P29/00A61P39/02A61P31/14A61P11/04
CPCA61K36/288A61K9/0095A61K36/195A61K36/315A61K36/539A61K36/86A61K47/26A61K2236/331A61K2236/53A61K2300/00
Inventor 徐寒梅戚微岩董瑶
Owner 江苏医耐韦德生物科技有限公司
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