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a ni 0.85 Se nanomaterials and their preparation methods and applications

A ni0.85se, nanomaterial technology, applied in the field of nanomaterial preparation and biomedicine, can solve the problems of poor biocompatibility, complex synthesis method, tedious surface modification, etc., achieve good biocompatibility, high photothermal The effect of conversion efficiency, good photothermal stability

Active Publication Date: 2019-11-15
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Complex synthesis methods, tedious surface modification, poor biocompatibility, etc., limit the Ni 0.85 Applications of Se Nanomaterials in Biomedicine
So far, no Ni 0.85 Reports of Se Nanomaterials in Tumor Photothermal Therapy, Chemotherapy and Photoacoustic Imaging

Method used

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  • a ni <sub>0.85</sub> Se nanomaterials and their preparation methods and applications
  • a ni <sub>0.85</sub> Se nanomaterials and their preparation methods and applications
  • a ni <sub>0.85</sub> Se nanomaterials and their preparation methods and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the surface does not have the Ni of hydrophilic ligand modification 0.85 Preparation of Se nanomaterials

[0031] (1) Under the protection of inert gas, dissolve 0.1mmol selenium powder and 0.3mmol sodium borohydride in 80mL water, mix well, and reduce the solution to colorless to obtain sodium selenium hydride solution;

[0032] (2) Dissolve 0.1mmol nickel chloride in the mixed solution of 20mL ultrapure water, add the sodium selenium hydride solution obtained in step (1) dropwise, stir at room temperature for 5min, and centrifuge to obtain Ni 0.85 Se nanomaterials

[0033] (3) Ni 0.85 Se nanomaterials were dialyzed in ultrapure water for 24 hours, and the water was changed every 3 to 4 hours to obtain black Ni 0.85 Aqueous solutions of Se nanomaterials.

Embodiment 2

[0034] Embodiment 2, the surface has the Ni of polyacrylic acid modification 0.85 Preparation of Se nanomaterials

[0035] (1) Under the protection of inert gas, dissolve 0.1mmol selenium powder and 0.3mmol sodium borohydride in 80mL water, mix well, and reduce the solution to colorless to obtain sodium selenium hydride solution;

[0036] (2) Dissolve 0.1 mmol nickel chloride in a mixed solution of 100 μL polyacrylic acid solution and 20 mL ultrapure water, add the sodium selenium hydride solution obtained in step (1) dropwise, stir at room temperature for 5 min, and centrifuge to obtain Ni 0.85 Se nanomaterials

[0037] (3) Ni 0.85 Se nanomaterials were dialyzed in ultrapure water for 24 hours, and the water was changed every 3 to 4 hours to obtain black Ni 0.85 Aqueous solutions of Se nanomaterials.

[0038] like figure 1 Shown, the Ni obtained by comparative example 1 (sample bottle on the right side of the figure) and embodiment 2 (sample bottle on the left side of th...

Embodiment 3

[0042]Embodiment 3, photothermal heating test

[0043] Get 3mL of Ni in different concentrations (0~500μM) in Example 2 0.85 The aqueous solution of Se nanomaterials is placed in the particle size pool, the probe of the digital display thermometer is immersed in the solution, and the 808nm laser is irradiated with a power of 2W for 10 minutes, and the temperature of the solution is recorded every 10 seconds, and the different concentrations of Ni are tested. 0.85 The photothermal heating curve of Se nanomaterials, the results are shown in Figure 5 . It can be seen that under 808nm laser irradiation, Ni 0.85 Se nanomaterials can reach higher temperatures at lower concentrations, suggesting that Ni 0.85 Se nanomaterials can be applied to photothermal therapy of tumors.

[0044] Image 6 for Ni 0.85 Photothermal stabilization effect diagram of Se nanomaterial aqueous solution irradiated 5 times under 808nm laser. Specifically take 3 mL of Ni with a concentration of 340 μM...

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Abstract

The invention discloses a Ni0.85Se nanomaterial as well as a preparation method and application thereof. The preparation method comprises the steps of stirring and mixing low-valence selenium anions with low-valence nickel cations for reaction in the presence of a hydrophilic ligand, and carrying out centrifugation and dialysis, so as to obtain the Ni0.85Se nanomaterial with excellent dispersity. The nanomaterial prepared by virtue of the preparation method has very strong near infrared absorption properties and photothermal conversion efficiency and relatively good photothermal stability, is capable of effectively converting near infrared ray into heat energy and can be applied to photothermal treatment of tumors; and furthermore, the prepared Ni0.85Se nanomaterial can be used as a drug carrier for chemotherapy of the tumors, or photoacoustic imaging, and therefore, the combined treatment of imaging-induced photothermal treatment and the chemotherapy is realized.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation and biomedicine, in particular to a Ni 0.85 Se nanomaterials and their preparation methods and applications. Background technique [0002] In recent years, the application of nanomaterials in biomedicine has attracted the attention of scientists, especially in disease diagnosis, disease prevention, drug treatment and other aspects have made great progress. The development of nanomaterials in biomedicine makes it possible to realize multiple functions in a single system at the same time. Multifunctional nanomaterials that can realize diagnosis and treatment at the same time are one of the current research hotspots. The realization of the integration of diagnosis and treatment can significantly improve the treatment effect of tumors. [0003] Near-infrared light has the advantages of strong tissue penetration and almost no damage to tissues, and is an ideal light source in the field of biom...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/30A61K41/00A61K49/22A61K9/51A61K47/02A61K47/42A61K47/32A61K47/36A61K45/00A61P35/00
CPCA61K9/5115A61K9/5138A61K9/5161A61K9/5169A61K41/0052A61K45/00A61K49/221
Inventor 查正宝王咸文马艳陈华健贺港周俊红
Owner HEFEI UNIV OF TECH
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