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Gold nanorod-lipid polymer vesicle with transdermal delivery function and preparation method and application of gold nanorod-lipid polymer vescle

A technology of gold nanorods and nanovesicles, which is applied in the field of medicine, can solve the problems of destroying the structure of the stratum corneum of the skin and skin irritation, and achieve the effects of enhancing transdermal efficiency, promoting release, and good biocompatibility

Active Publication Date: 2017-06-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these studies need to combine ultrasound or an external magnetic field to promote transdermal efficiency in order to achieve the desired therapeutic effect. Although some chemical penetration enhancers can also improve the transdermal effect of drugs, chemical penetration enhancers Often destroys the stratum corneum structure of the skin and produces certain irritation to the skin

Method used

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  • Gold nanorod-lipid polymer vesicle with transdermal delivery function and preparation method and application of gold nanorod-lipid polymer vescle
  • Gold nanorod-lipid polymer vesicle with transdermal delivery function and preparation method and application of gold nanorod-lipid polymer vescle
  • Gold nanorod-lipid polymer vesicle with transdermal delivery function and preparation method and application of gold nanorod-lipid polymer vescle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of gold nanorod-lipopolymer vesicles

[0039] (1) Preparation of polymer PSAA

[0040]Using a high-pressure reactor as a reactor, allyl alcohol (AA), dicumyl peroxide (DCP) and styrene (ST) are added to the reactor, nitrogen is used as a protective agent, and allyl alcohol and styrene are used as The mass of the two reaction raw materials is 0.5g and 0.5g respectively, dicumyl peroxide is used as the initiator, the addition amount is 1mg, the reaction temperature is 50°C, and the reaction time is 1h, and the polymer PSAA is finally obtained.

[0041] (2) Preparation of lipopolymer vesicles

[0042] Under pulsed ultrasound, the polymer 5gPSAA was mixed with 5mL ultrapure water, and dioleoylphosphatidylethanolamine and (2,3-dioleoyl-propyl)-trimethylamine mixed in any ratio were added as surfactants. The quality of the surfactant is 1 mg, and lipopolymer vesicles are prepared.

[0043] (3) Preparation of gold nanorods

[0044] When light is incident on the...

Embodiment 2

[0051] Preparation of gold nanorod-lipopolymer vesicles

[0052] (1) Preparation of polymer PSAA

[0053] Using a high-pressure reactor as a reactor, allyl alcohol (AA), dicumyl peroxide (DCP) and styrene (ST) are added to the reactor, nitrogen is used as a protective agent, and allyl alcohol and styrene are used as The mass of the two reaction raw materials is 5g and 0.5g respectively, dicumyl peroxide is used as the initiator, the addition amount is 550mg, the reaction temperature is 150°C, and the reaction time is 10h, and the polymer PSAA is finally obtained.

[0054] (2) Preparation of lipopolymer vesicles

[0055] Under pulsed ultrasound, the polymer 5gPSAA was mixed with 50mL ultrapure water, and dioleoylphosphatidylethanolamine and (2,3-dioleoyl-propyl)-trimethylamine mixed in any ratio were added as surfactants. The quality of the surfactant was 550mg, and the lipopolymer vesicles were prepared.

[0056] (3) Preparation of gold nanorods

[0057] When light is inci...

Embodiment 3

[0064] Validation of gold nanorod-lipopolymer vesicles

[0065] (1) Particle size measurement of gold nanorod-lipopolymer vesicles

[0066] First use ultrapure water to adjust the gold nanorods synthesized in Example 1 to 100 μg / mL, and measure the size of the gold nanorods under the Malvern laser particle size analyzer, the results are as follows figure 1 shown.

[0067] Use ultrapure water to adjust the lipopolymer vesicles synthesized in Example 1 to 100 μg / mL, measure the size of lipopolymer vesicles under the Malvern laser particle size analyzer, the results are as follows figure 2 shown.

[0068] Use ultrapure water to adjust the gold nanorods-lipopolymer vesicles synthesized in Example 1 to 100 μg / mL, and measure the size of the gold nanorods-lipopolymer vesicles under the Malvern laser particle sizer, the result Such as image 3 shown.

[0069] (2) Morphological observation of gold nanorods

[0070] Get the gold nanorod solution of Example 1, drop it on a dedica...

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Abstract

The invention discloses gold nanorod-lipid polymer vesicle with the transdermal delivery function and a preparation method and application of the gold nanorod-lipid polymer vescle. The nano vesica include the lipid polymer vesicle and a gold nanorod attached to the interior of the lipid polymer vesicle, the nano vesica good in stability have thermal responsiveness and good biocompatibility, the lipid structure on the uttermost side can be fused with skin keratinocytes to penetrate the skin to enter subcutaneous tumor site, good gene therapy and thermal therapy effect on melanoma on the surface of the skin is achieved, and the advantages of targeted controllable drug delivery is realized. Efficient gene therapeutic effect is achieved, and the gold nanorod-lipid polymer vesicle is quite possible to be good carrier for local delivery of gene drugs; the carrier system has wide application prospect in treating tumors of the melanoma of the skin through transdermal genes; new research thought and technical reference are provided for design of a further gene drug transdermal delivery system.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a gold nanorod-lipid polymer vesicle with the function of transdermal drug delivery and its preparation method and application. Background technique [0002] Transdermal therapeutic system (TTS) refers to the drug delivery on the surface of the skin, and the drug penetrates the stratum corneum, epidermis, and dermis at a constant speed, and finally enters the systemic circulation to produce systemic or local therapeutic effects. Compared with oral and injection administration, it has the following three advantages: 1. The administration method is convenient, has less impact on the human body and the administration can be stopped in time when side effects occur; 2. It can avoid the first-pass effect produced by the liver and improve Drug bioavailability; 3. It is conducive to the controlled and slow release of drugs over a period of time. However, while the stratum corneum effec...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K48/00A61K41/00A61K31/7088A61P35/00
CPCA61K9/0004A61K9/0019A61K9/1273A61K31/7088A61K41/0052
Inventor 彭丽华牛杰
Owner ZHEJIANG UNIV
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