A kind of preparation method and application of amphiphilic polymer
An amphiphilic polymer and preparation technology, applied in the field of medicine, can solve the problems of many adverse reactions, poor absorption of insoluble drugs, low bioavailability, etc., achieve good tumor inhibition, improve bioavailability, and reduce toxic and side effects. Effect
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Embodiment 1
[0022] The preparation method of amphiphilic polymer of the present invention comprises the following steps:
[0023] (1) Mix 8.4g of maleic anhydride and 30ml of 2-octyl-dodecane Guerbet alcohol, stir magnetically at 60°C, and freeze the product at -20°C after 5 hours of reaction. After solidification, wash with methanol Mix 50ml of the mixed solution with water at a volume ratio of 4:6, wash the reaction product, remove excess unreacted maleic anhydride, and dry to obtain Guerbet eicosanol monoester maleate;
[0024] (2) Take 0.1g of initiator lauroyl peroxide, 9g of N-vinylpyrrolidone and 1g of Guerbet eicosanol monoester maleate obtained in step (1), add 150ml of n-heptane, and protect it under nitrogen for 70 ℃, mechanical stirring, a white precipitate was obtained;
[0025] (3) The white precipitate obtained in step (2) was washed 5 times with 150 ml of n-heptane at 40°C, filtered with suction, and dried at room temperature for 48 hours to obtain an amphiphilic polymer....
Embodiment 2
[0027] The preparation method of amphiphilic polymer of the present invention comprises the following steps:
[0028] (1) Mix 5.6g of maleic anhydride and 20ml of 2-octyl-dodecane Guerbet alcohol, stir magnetically at 80°C, and freeze the product at -10°C after reacting for 7 hours. After solidification, wash with methanol Mix 150ml of the mixed solution with water at a volume ratio of 2:8, wash the reaction product, remove excess unreacted maleic anhydride, and dry to obtain Guerbet eicosanol monoester maleate;
[0029] (2) Take 0.02g of the initiator lauroyl peroxide, 7g of N-vinylpyrrolidone and 3g of Guerbet eicosanol monoester maleate obtained in step (1), add 250ml of n-heptane, and protect it under nitrogen at 90 ℃, mechanical stirring, a white precipitate was obtained;
[0030] (3) The white precipitate obtained in step (2) was washed three times with 50 ml of n-heptane at 60°C, filtered with suction, and dried at room temperature for 24 hours to obtain an amphiphilic...
Embodiment 3
[0032] The preparation method of amphiphilic polymer of the present invention comprises the following steps:
[0033] (1) Mix 15g of maleic anhydride and 60ml of 2-octyl-dodecane Guerbet alcohol, stir magnetically at 70°C, and freeze the product at 0°C after 6 hours of reaction. After solidification, wash with methanol and water According to the volume ratio of 2:8 mixed solution 250ml, rinse the reaction product, remove excess unreacted maleic anhydride, dry to obtain Guerbet eicosanol monoester maleate;
[0034] (2) Take 0.2g of the initiator lauroyl peroxide, 8g of N-vinylpyrrolidone and 2g of Guerbet eicosanol monoester maleate obtained in step (1), add 170ml of n-heptane, and protect it under 80 ℃, mechanical stirring, a white precipitate was obtained;
[0035] (3) Wash the white precipitate obtained in step (2) with 250 ml of n-heptane at 70°C for 4 times, filter it with suction, and dry it at room temperature for 36 hours to obtain an amphiphilic polymer.
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