Tantalum-doped hydroxyapatite coating bone implantation material and preparation method thereof

A technology of tantalum hydroxyapatite and bone implant materials, which is applied in coating, metal material coating process, pharmaceutical formulation, etc. The effect of promoting adhesion

Inactive Publication Date: 2017-02-22
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to reports, additives such as titanium, zirconium, strontium, zinc, and calcium can improve the mechanical properties of HA coatings and the osseointegration ability of implants, but other properties are not ideal, such as porosity, pore size, etc.

Method used

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  • Tantalum-doped hydroxyapatite coating bone implantation material and preparation method thereof
  • Tantalum-doped hydroxyapatite coating bone implantation material and preparation method thereof
  • Tantalum-doped hydroxyapatite coating bone implantation material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0042] The preparation methods of the four embodiments are identical, as follows:

[0043] Using pure titanium sheet as matrix, and pretreatment:

[0044] First, use metallographic sandpaper to grind and polish the metal sheet to 400 mesh step by step, then ultrasonically clean it with acetone, anhydrous ethanol and deionized water for 10 minutes, and the frequency is 40KHz; It was ultrasonically cleaned with acetone, anhydrous ethanol and deionized water for 10 min in sequence, and the frequency was 30 KHz.

[0045]Mix medical tantalum powder (particle size 35-75 μm) and hydroxyapatite (particle size 15-50 μm) according to the preset mass ratio, put it in a ball mill for full ball milling for 4 hours (rotation speed is 200 rpm), dry and sieve . Atmospheric plasma spraying equipment is used, with argon as the main gas (air supply volume 47L / min) and helium as the auxiliary (air supply volume 12L / min). Under the conditions of power 30KW, powder feeding rate 13g / min, and spra...

Embodiment 5-7

[0051] The only difference from Example 1 is the thickness of the coating, which is 90 μm, 100 μm, and 130 μm, respectively.

[0052] The SEM photos show that the material coatings of Examples 5 to 7 all have a multi-level pore structure.

[0053] The pore size range, porosity, coating bonding strength and coating surface roughness of Examples 5 to 7 were tested, and the results are shown in Table 2.

[0054] Table 2

[0055]

[0056]

Embodiment 8

[0058] Using pure titanium sheet as matrix, and pretreatment:

[0059] First, use metallographic sandpaper to grind and polish the metal sheet to 400 mesh step by step, then ultrasonically clean it with acetone, anhydrous ethanol and deionized water for 10 minutes, and the frequency is 40KHz; It was ultrasonically cleaned with acetone, anhydrous ethanol and deionized water for 10 min in sequence, and the frequency was 30 KHz.

[0060] Mix medical tantalum powder (particle size: 35-75μm) and hydroxyapatite (particle size: 15-50μm) in a mass ratio of 9:1, put it in a ball mill for full ball milling for 4 hours (rotation speed is 200 rpm), dry and sieve . Atmospheric plasma spraying equipment is used, with argon as the main gas (gas supply volume 55L / min) and helium as the auxiliary (gas supply volume 8L / min). Under the conditions of power 30KW, powder feeding rate 13g / min, and spraying distance of 100mm, the mixed powder is uniformly sprayed on the pure titanium sheet after sa...

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Abstract

The invention provides a tantalum-doped hydroxyapatite coating bone implantation material and a preparation method thereof. The tantalum-doped hydroxyapatite coating bone implantation material comprises a metal matrix and a composite coating, wherein the composite coating comprises tantalum and hydroxyapatite, and the weight ratio of tantalum in the composite coating is 60%-90%; and the porosity of the composite coating is 18%-22%. Mixed powder of tantalum and hydroxyapatite is melted and is sprayed to metal matrix by virtue of an atmosphere plasma spraying method; the spraying conditions are as follows: the spraying power is 20KW-30KW, the powder feeding velocity is 10g/min-15g/min, the argon feeding quantity is 35L/min-55L/min, and the helium feeding quantity is 8L/min-20L/min. By virtue of the preparation method, the binding strength between the coating and the matrix is enhanced, the porosity of the coating is improved, and the material has good biological activity and is capable of promoting the adhesion and proliferation of cells and bone-formation differentiation and is beneficial to the restoring and regeneration of bone tissues.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a tantalum-doped hydroxyapatite-coated bone implant material and a preparation method thereof. Background technique [0002] Titanium and titanium alloys have become the most widely used bone implant materials in orthopaedics and stomatology due to their excellent mechanical properties and biocompatibility. The surface morphology and chemical composition of metallic bone implant materials determine their biological activity, thereby affecting the clinical success rate of implants. However, it lacks biological activity and is difficult to form ideal osseointegration with surrounding bone. The coating modification can improve the physicochemical properties of the implant surface to regulate the biological behaviors such as cell adhesion, migration, proliferation and osteogenic differentiation, and promote the formation of fast and firm osseointegration between the implan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/30A61L27/50C23C4/134C23C4/06
CPCA61L27/32A61L27/306A61L27/50A61L2400/18A61L2420/02A61L2420/04A61L2430/02C23C4/06
Inventor 刘洪臣路荣建贺慧霞
Owner GENERAL HOSPITAL OF PLA
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