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Biodegradable medical zinc-lithium binary alloy material and preparation method and application thereof

A binary alloy and alloy material technology, which is applied in medical science, tissue regeneration, prosthesis and other directions, can solve the problems of process duplication, slow corrosion rate, poor comprehensive mechanical properties of pure zinc, etc., and achieves simple alloy preparation process and improved strength. and plasticity, easy to control the effect of material quality

Inactive Publication Date: 2017-01-04
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the comprehensive mechanical properties of pure zinc are poor, and the corrosion rate is also slow, which is difficult to meet the needs of clinical medicine. Alloying pure zinc is the main method to improve its mechanical properties and corrosion rate. Fe, Li and trace elements Mg, Ca, Sr, Si, Mn and rare earth elements are added to zinc at the same time, but the strength and plasticity of the zinc alloy material prepared by this technology are low, and the performance of the ideal material for vascular stents is not yet achieved. Require
At the same time, it contains more alloying elements. On the one hand, more types of alloying elements are released during the degradation process, which increases the potential risk to the human body. On the other hand, the duplication of the alloy preparation process increases the difficulty of quality control of the material, and the corresponding alloy cost also increases. up

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  • Biodegradable medical zinc-lithium binary alloy material and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0034] This embodiment relates to a degradable medical Zn-Li alloy material, which includes the following alloy components in weight percentage: Li is 0.55%, and the rest is Zn.

[0035] The preparation steps of the alloy material are as follows:

[0036] S1. Weigh each raw material according to the above alloy ratio;

[0037]S2. Put pure zinc (purity ≥ 99.995%) into an iron crucible with a protective coating on the inner wall, raise the temperature to 420°C and wait for the pure zinc to completely melt, then raise the temperature of the zinc melt to 580°C, then add LiCl and LiF Mix flux (mass ratio is 1: 3), after the above-mentioned mixed solvent completely covers the surface of zinc melt, then lower the temperature of zinc melt to 540°C, at this time add pure lithium (purity ≥ 99.999% ), after the pure lithium is melted, stir evenly to form an alloy melt;

[0038] S3. Refining the alloy melt with hexachloroethane, the refining temperature is 540±5°C, and the amount of hex...

Embodiment 2

[0041] This embodiment relates to a degradable medical Zn-Li alloy material, which includes the following alloy components in weight percentage: Li is 10%, and the rest is Zn.

[0042] The preparation method of this alloy material is the same as embodiment 1, and difference is:

[0043] S2. Put in pure zinc and raise the temperature to 430°C. After the pure zinc is completely melted, raise the temperature of the zinc melt to 600°C. At this time, add LiCl and LiF mixed flux (mass ratio: 1:3), until the above mixed solvent is completely covered After the surface of the zinc melt is removed, the temperature of the zinc melt is lowered to 550°C, and then pure lithium is added under the protection of Ar gas;

[0044] s3. The refining temperature is 540±10°C, and the amount of hexachloroethane is 0.2% of the total weight of the alloy melt; after refining, stand still at 540±10°C for 10 minutes;

[0045] S4. The homogenization treatment temperature is 320°C, and the treatment time i...

Embodiment 3

[0047] This embodiment relates to a degradable medical Zn-Li alloy material, which includes the following alloy components in weight percentage: Li is 4.1%, and the rest is Zn.

[0048] The preparation method of this alloy material is the same as embodiment 1, and difference is:

[0049] S2. Put in pure zinc and raise the temperature to 440°C. After the pure zinc is completely melted, raise the temperature of the zinc melt to 590°C. At this time, add LiCl and LiF mixed flux (mass ratio: 1:3), until the above mixed solvent is completely covered After the surface of the zinc melt is removed, the temperature of the zinc melt is lowered to 560°C, and then pure lithium is added under the protection of Ar gas;

[0050] S3. The refining temperature is 540±10°C, and the amount of hexachloroethane is 0.3% of the total weight of the alloy melt; after refining, stand still at 540±10°C for 15 minutes;

[0051] S4. The homogenization treatment temperature is 380° C., and the treatment tim...

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Abstract

The invention discloses a biodegradable medical zinc-lithium binary alloy material and a preparation method and application thereof. The biodegradable medical zinc-lithium binary alloy material is composed of, by weight, 0.55%-10% of lithium and the balance zinc. Alloy obtained through smelting further needs to be subjected to thermoplastic deformation processing before being used, so that the alloy structure is refined and the performance of the alloy is improved. The zinc alloy has the advantages of being excellent in comprehensive mechanical property, good in biocompatibility, controllable in degradation rate and the like, can be used as a material for preparing a degradable medical implantable instrument and is applied to prepare endovascular stents, bone implants, maxillofacial surgery and craniocerebral surgery implantable instruments, surgical sutures, various surgical patches, anastomats, vascular clamps or neural restoration catheters and the like.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a biodegradable medical zinc-lithium binary alloy material and a preparation method and application thereof. Background technique [0002] At present, the medical materials implanted into the human body are generally made of non-degradable metal materials, such as (1) austenitic stainless steel (316LSS); (2) cobalt-chromium alloy; (3) medical tantalum; (4) titanium and Its alloy; (5) nickel-titanium shape memory alloy. The application of these permanent implant materials has the following disadvantages, for example (1) after the permanent metal vascular stent is implanted into the human body, due to its non-degradability, there is a shortcoming of easily forming thrombus to cause restenosis and intimal fibrosis in the stent, and the stent It remains permanently in the body and cannot be taken out again. Once the blood vessel is blocked again at the same position, ...

Claims

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Application Information

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IPC IPC(8): C22C18/00C22C1/02C22C1/06C22F1/16A61L17/06A61L27/04A61L27/58A61L31/02A61L31/14
CPCC22C18/00A61L17/06A61L27/047A61L27/58A61L31/022A61L31/148A61L2430/02A61L2430/32C22C1/02C22C1/06C22F1/165
Inventor 袁广银岳锐黄华
Owner SHANGHAI JIAO TONG UNIV
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