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Chitosan hydrogel, and preparation method and application thereof

A technology of chitosan and sugar water, applied in the field of biomedical materials, can solve the problems of poor mechanical properties, high brittleness and poor water solubility of chitosan, and achieve the effects of low mechanical strength, fast degradation rate and soft physical properties

Inactive Publication Date: 2015-06-17
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, due to the disadvantages of chitosan's poor mechanical properties, high brittleness, and poor water solubility, it has become the main obstacle to its application in surgical trauma accessories.

Method used

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  • Chitosan hydrogel, and preparation method and application thereof
  • Chitosan hydrogel, and preparation method and application thereof
  • Chitosan hydrogel, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: the preparation of PNC-PEG-PNC (III)

[0057] Polyethylene glycol (I) (PEG, 10.0 g, molecular weight 3000, monomer molecular weight 62, hydroxyl mole number 5 mmol) was dissolved in 100 mL of dichloromethane. 4-Dimethylaminopyridine (0.916 g, 7.5 mmol) and triethanolamine (0.759 g, 7.5 mmol) dissolved in 20 mL of dichloromethane were added under nitrogen protection. After stirring for 15-20 min, p-nitrobenzene chloroformate (II) (PNC) (1.511 g, 7.5 mmol) dissolved in 50 mL of dichloromethane was added to the solution. Stir the reaction at room temperature under the protection of nitrogen for 12 hours; remove most of the dichloromethane by rotary evaporation, add anhydrous ether for sedimentation, and filter to obtain a white solid. The solid was washed three times with anhydrous ether, and dried in vacuo to obtain a white solid powder with a yield of 82.1%.

Embodiment 2

[0058] Embodiment 2: the preparation of PNC-PEG-PNC (III)

[0059] Polyethylene glycol (I) (PEG, 10.0 g, molecular weight 4000, monomer molecular weight 62, hydroxyl mole number 5 mmol) was dissolved in 50 mL of dichloromethane. 4-Dimethylaminopyridine (0.916 g, 7.5 mmol) and triethanolamine (0.759 g, 7.5 mmol) dissolved in 10 mL of dichloromethane were added under nitrogen protection. After stirring for 15-20 min, p-nitrobenzene chloroformate (II) (PNC) (1.511 g, 7.5 mmol) dissolved in 25 mL of dichloromethane was added to the solution. Stir the reaction at room temperature under the protection of nitrogen for 24 hours; remove most of the dichloromethane by rotary evaporation, add anhydrous ether for sedimentation, and filter to obtain a white solid. The solid was washed three times with anhydrous ether, and dried in vacuo to obtain a white solid powder with a yield of 79.1%.

Embodiment 3

[0060] Embodiment 3: the preparation of PNC-PEG-PNC (III)

[0061] Polyethylene glycol (I) (PEG, 10.0 g, molecular weight 5000, monomer molecular weight 62, hydroxyl mole number 5 mmol) was dissolved in 150 mL of dichloromethane. 4-Dimethylaminopyridine (1.221 g, 10 mmol) and triethanolamine (1.102 g, 10 mmol) dissolved in 30 mL of dichloromethane were added under nitrogen protection. After stirring for 15-20 min, p-nitrobenzene chloroformate (II) (PNC) (2.015 g, 10 mmol) dissolved in 30 mL of dichloromethane was added to the solution. Stir the reaction at room temperature under the protection of nitrogen for 36 hours; remove most of the dichloromethane by rotary evaporation, add anhydrous ether for sedimentation, and filter to obtain a white solid. The solid was washed three times with anhydrous ether, and dried in vacuo to obtain a white solid powder with a yield of 83.2%.

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Abstract

The invention discloses a chitosan hydrogel. The structural unit of the chitosan hydrogel is shown in the specification; and in the structural unit, m is a natural number in a range of 400-700, and n is a natural number in a range of 30-100. The invention also discloses a preparation method of the chitosan hydrogel, and an application of the chitosan hydrogel. The method comprises the following steps: polyethylene glycol and tyramine molecules are grafted to a chitosan molecular chain in order to obtain a highly-water-soluble chitosan derivative, and the derivative is processed under the action of a crosslinking reagent to obtain the chitosan hydrogel. The process of the preparation method is simple, and the prepared chitosan hydrogel has the advantages of good physical, chemical and biological performances, good histocompatibility, environmental protection, and non-toxicity, and can be safely and effectively applied in restoration of wound tissues.

Description

technical field [0001] The invention relates to a chitosan hydrogel and a preparation method and application thereof, belonging to the technical field of biomedical materials. Background technique [0002] Gel is a spatial network structure formed by polymers in a solution under certain conditions, and the solution is dispersed in it as a filling medium. Hydrogel, as the name implies, is a gel with water as the medium. Its physical properties are soft, and it can absorb a large amount of water in various combinations. After swelling, it forms a three-dimensional network structure. Due to the high water content, the polymer material can also have some fluidity The nature of this is similar to human tissue, so the polymer hydrogel has good biocompatibility, and the polymer hydrogel has tissue affinity. Based on the above characteristics, polymer hydrogels have been widely used in the fields of biological tissue engineering and tissue repair. [0003] There are many types of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08J3/075C08J3/24C08J9/28C08B37/08C08G65/48C08G81/00A61L15/28A61L15/42A61L15/44A61K31/722A61K9/06A61P17/02
Inventor 苏贤斌沈冬健王园园李金科
Owner NANJING UNIV OF TECH
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