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Synthesis method of mesoporous beta-tricalcium phosphate microemulsion

A technology of tricalcium phosphate and synthesis methods, which is applied in the fields of phosphorus compounds, chemical instruments and methods, and inorganic chemistry. Effect of surface area, good biocompatibility

Active Publication Date: 2015-04-08
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, mesoporous β-TCP is rarely reported due to its crystal habit and synthesis difficulty.

Method used

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  • Synthesis method of mesoporous beta-tricalcium phosphate microemulsion
  • Synthesis method of mesoporous beta-tricalcium phosphate microemulsion
  • Synthesis method of mesoporous beta-tricalcium phosphate microemulsion

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Add surfactant CTAB, oil phase cyclohexane and cosurfactant 1-octanol to 50mL water, wherein the concentration of surfactant is 100g / L, the concentration of oil phase is 250mL / L, and the concentration of cosurfactant is 250mL / L L, stirred at 37°C for 50min to obtain a microemulsion, and then 20mL of 0.3mol / L Ca(NO 3 ) 2 4H 2 The O solution was slowly added dropwise into the microemulsion, and magnetic stirring was continued for 30 min. Add 0.3mol / L (NH 4 ) 2 HPO 4 solution, and make the element Ca / P (molar ratio) = 1.5, use NH 3 ·H 2 The pH of the O solution was adjusted to 8.0, and the magnetic stirring was continued for 24 hours, then left to age at room temperature for 24 hours, centrifuged at 10,000 rpm for 2 minutes, and the obtained precipitate was washed three times with water and then three times with alcohol. Finally, the precipitate was dried in a drying oven at 80°C for 24h, then heated to 800°C at a rate of 5°C / min at room temperature, and heat-treate...

Embodiment 2

[0027] Add surfactant sodium dodecylbenzenesulfonate, oil phase n-octane and co-surfactant n-propanol to 100mL water, wherein the concentration of surfactant is 25g / L, and the concentration of oil phase is 50mL / L, to help the surface The active agent concentration is 50mL / L, stirred at 90°C for 35min to obtain a microemulsion, and then 60mL of 0.9mol / L CaCO 3 The solution was slowly added dropwise into the microemulsion, and magnetic stirring was continued for 40 min. Slowly add 0.9mol / L H at a rate of 0.6mL per minute 3 PO 4 solution, and make the element Ca / P (molar ratio) = 1.5, use NH 3 ·H 2The pH of the O solution was adjusted to 9.0, and magnetic stirring was continued for 2 hours, then left to age at room temperature for 12 hours, centrifuged at 10,000 rpm for 4 minutes, and the obtained precipitate was washed twice with water and then twice with alcohol. Finally, the precipitate was dried in a drying oven at 120°C for 12 hours, then heated to 950°C at a rate of 10°...

Embodiment 3

[0029] Add surfactant polyoxyethylene-polyoxypropylene-polyoxyethylene, oil phase n-hexane and co-surfactant n-butanol to 40mL water, wherein the concentration of surfactant is 50g / L, and the concentration of oil phase is 100mL / L, The co-surfactant concentration is 100mL / L, stirred at 25°C for 60min to obtain a microemulsion, and then 25mL of 0.5mol / L CaCl 2 The solution was slowly added dropwise into the microemulsion, and magnetic stirring was continued for 30 minutes. Slowly add 0.5 mol / L of NH at a rate of 0.2 mL per minute 4 h 2 PO 4 solution, and make the element Ca / P (molar ratio) = 1.5, use NH 3 ·H 2 The pH of the O solution was adjusted to 6.0, and magnetic stirring was continued for 12 hours, then left to age at room temperature for 24 hours, and centrifuged at 9500 rpm for 3 minutes to obtain a precipitate, which was washed three times with water and then washed once with alcohol. Finally, the precipitate was dried in a drying oven at 80°C for 22 hours, then he...

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Abstract

The invention relates to a synthesis method of a mesoporous beta-tricalcium phosphate microemulsion. The method comprises the following steps: 1) adding a surfactant, an oil phase and a co-surfactant to water, and stirring evenly, so as to obtain a microemulsion; 2) adding a calcium inorganic salt solution to the microemulsion, fully stirring, adding a phosphorous inorganic salt solution, adjusting the pH value of the emulsion, keeping the temperature invariable, and stirring to obtain the emulsion; and 3) standing, ageing, separating out sediments by using a centrifuging method, washing, drying, then putting into a high-temperature furnace, heating, and carrying out heat preservation, so as to obtain mesoporous beta-TCP powder. The synthesis method has the beneficial effects that 1, the synthesis method disclosed by the invention is simple, easy to operate, good in repeatability and low in energy consumption; and 2, the mesoporous beta-TCP powder obtained by the synthesis method disclosed by the invention is relatively small in aperture, and has a three-dimensional pore structure; the mean pore size is 7.11-20.25nm; and the specific surface area is 12.85-156.38m<2> / g.

Description

technical field [0001] The invention relates to a microemulsion synthesis method of mesoporous β-tricalcium phosphate. Background technique [0002] β-TCP[β-Ca 3 (PO 4 ) 2 ] is an inorganic biomedical material. β-TCP can be directly combined with bone tissue, does not prevent the normal activity of bone cells on its surface or interfere with the natural regeneration process of bone cells around it, and is conductive to the decomposition and absorption of bone tissue; through itself or adding osteoinductive factors, stimulate Or induce bone growth, has the ability to induce regeneration; within a certain period of time, it is replaced by the host bone, does not affect the repair of bone tissue, and has no toxic and side effects. β-TCP can be used to make bone filling and repair materials, etc., and is a hot spot in the development of biomedical materials. The structure and properties of mesoporous materials are between amorphous inorganic porous materials (such as amorph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
Inventor 戴红莲黄岸喻莹韩颖超李世普
Owner WUHAN UNIV OF TECH
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