Preparation method of rare earth chemical drug lanthanum carbonate chewable tablet

Abstract

The invention discloses a preparation method of lanthanum carbonate chewable tablet of rare earth chemical medicine, which relates to rare earth chemical medicine. Purify the separated product of ionic rare earth ores - lanthanum oxide purchased from the market, the rare earth lanthanum oxide of the separated product of ionic rare earth ores - lanthanum oxide accounts for 99.99% of the total amount of rare earths, remove the impurities in the rare earth lanthanum oxide, and realize Rare earth lanthanum is separated from other rare earths; the impurities include oxides of other rare earth elements other than lanthanum oxide and non-rare earth impurity elements; ion exchange resin adsorption and desorption principles are used for exchange, firstly make a plexiglass ion exchange column, and the exchange column is filled Ion-exchange resin, the ion-exchange resin is washed with 2N HCl until iron-free, washed with water until neutral, and soaked for later use; separates rare earth lanthanum from non-rare earth impurities; then washes with water to remove nitrogen triacetic acid to realize the separation of rare earth lanthanum from other rare earths; The obtained pure rare earth lanthanum ions are precipitated with ammonium bicarbonate to obtain lanthanum carbonate crystals, which are sterilized and dried to make chewable tablets of rare earth chemical medicine lanthanum carbonate.

Description

technical field [0001] The invention relates to rare earth chemical medicines, in particular to a preparation method of rare earth chemical medicine lanthanum carbonate chewable tablets. Background technique [0002] FOSRENOL of the United States found that the combination of rare earth metal lanthanum ions and phosphorus ions produces insoluble precipitates, which are excreted from the body along with the digestive tract and do not enter the blood circulation system. A large number of sick subjects do not produce adverse side effects, which is obviously better than the curative effect of calcium carbonate, calcium acetate, and aluminum carbonate. [0003] Since the invention of lanthanum carbonate chewable tablets, especially in recent years, it has been promoted to 42 countries around the world, and 90% of patients with hyperphosphatemia in the United States have recovered. The drug entered China in 2012 and has become the only main drug for the treatment of hyperphosphat...

AI Technical Summary

Problems solved by technology

One is that the drug price of Fosslino Lanthanum Carbonate Chewable Tablets in the United States is very expensive, and without medical insurance, most patients are difficult to bear the pressure of huge dialysis fees, and it is even more difficult to accept the high price of Lanthanum Carbonate, so they are forced to give up treatment; the other is Science propaganda is not yet widespread