Preparation method of rare earth chemical drug lanthanum carbonatechewable tablets

Abstract

The invention provides a preparation method of rare earth chemical drug lanthanum carbonatechewable tablets, and relates torare earth chemical drugs. The preparation methodcomprises the following steps: a separationproductlanthanum oxideof ion-absorbed rare earth ore purchased from the market is purified, rare earth lanthanum oxideof the separationproductlanthanum oxide of the ion-absorbed rare earth ore accounts for 99.99% of the total amount of rare earth, impurities in rare earth lanthanum oxide are removed, and rare earth lanthanum is separated from other rare earth, wherein the impurities comprise oxides of rare earth elements excluding lanthanum oxide as well as non-rare earth impurity elements; exchange is performed through ion exchange resinabsorption and desorption principle, an organic glass ion exchange column is produced firstly, then the exchange column is filled with ion exchange resin, the ion exchange resin is washed by 2NHCl until the resin doesn't contain iron and then washed by water until the resin is neutral, and resin is soaked for standby application; rare earth lanthanum and non-rare earth impurities are separated; nitrilortiacetic acid is removed through water washing, and the rare earth lanthanum is separated from other rare earth; and obtained pure rare earth lanthanum ions are precipitated by ammonium bicarbonate to obtain a lanthanum carbonate crystal which is sterilized and dried to prepare the rare earth chemical drug lanthanum carbonatechewable tablets.

Description

technical field [0001] The invention relates to rare earth chemical medicines, in particular to a preparation method of rare earth chemical medicine lanthanum carbonate chewable tablets. Background technique [0002] FOSRENOL of the United States found that the combination of rare earth metal lanthanum ions and phosphorus ions produces insoluble precipitates, which are excreted from the body along with the digestive tract and do not enter the blood circulation system. A large number of sick subjects do not produce adverse side effects, which is obviously better than the curative effect of calcium carbonate, calcium acetate, and aluminum carbonate. [0003] Since the invention of lanthanum carbonate chewable tablets, especially in recent years, it has been promoted to 42 countries around the world, and 90% of patients with hyperphosphatemia in the United States have recovered. The drug entered China in 2012 and has become the only main drug for the treatment of hyperphosphat...

AI Technical Summary

Problems solved by technology

One is that the drug price of Fosslino Lanthanum Carbonate Chewable Tablets in the United States is very expensive, and without medical insurance, most patients are difficult to bear the pressure of huge dialysis fees, and it is even more difficult to accept the high price of Lanthanum Carbonate, so they are forced to give up treatment; the other is Science propaganda is not yet widespread