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Method for preparing compound aspirin double-layer tablet

A double-layer tablet, aluminum-magnesium technology, applied in the direction of aluminum/calcium/magnesium active ingredients, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of easy decomposition, affecting the stability of aspirin, etc. Dissolution effect is good, the effect of avoiding irritation and damage

Active Publication Date: 2015-03-25
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method adopts wet granulation to aspirin, which seriously affects the stability of aspirin and is easy to decompose

Method used

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  • Method for preparing compound aspirin double-layer tablet
  • Method for preparing compound aspirin double-layer tablet
  • Method for preparing compound aspirin double-layer tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of Al-Mg double-layer tablets is based on the amount of 1000 tablets, and the preparation process is as follows:

[0027] 1) Mix 330g of aspirin through a 100-mesh sieve, 3.3g of tartaric acid, 10g of low-substituted hydroxypropyl cellulose, 37g of starch and 15g of talcum powder, and put them into a tablet machine to compress to obtain tablet A;

[0028] 2) After dissolving 0.017g of lemon yellow with a small amount of purified water, add 6g of starch, then add a small amount of purified water and stir evenly, then add boiling purified water, continue stirring until the slurry is cooked, and prepare 10% starch slurry;

[0029] 3) Grind 100g of heavy magnesium carbonate and 50g of glyoxate, pass through a 40-mesh sieve, mix with 12g of starch evenly, add a small amount of starch slurry in step 2) and stir at high speed for 200 seconds, then gradually pour in the remaining starch slurry and stir at high speed 1. Cut for 60 seconds, granulate, pass through...

Embodiment 2

[0033] The preparation of Al-Mg double-layer tablets is based on the amount of 1000 tablets, and the preparation process is as follows:

[0034] 1) Mix 330g of aspirin through a 100-mesh sieve, 3.3g of tartaric acid, 8g of low-substituted hydroxypropyl cellulose, 40g of starch and 12g of talcum powder, and put them into a tablet machine to compress to obtain tablet A;

[0035] 2) After dissolving 0.015 g of lemon yellow with a small amount of purified water, add 4 g of starch, then add a small amount of purified water and stir evenly, then add boiling purified water, continue stirring until the slurry is cooked, and prepare 10% starch slurry;

[0036] 3) Grind 100g of heavy magnesium carbonate and 50g of glyoxate, pass through a 40-mesh sieve, mix evenly with 10g of starch, add a small amount of starch slurry from step 2) and stir for 200 seconds at high speed, then gradually pour in the remaining starch slurry and stir at high speed 1. Cut for 60 seconds, granulate, pass thro...

Embodiment 3

[0040] The preparation of Al-Mg double-layer tablets is based on the amount of 1000 tablets, and the preparation process is as follows:

[0041] 1) Mix 330g of aspirin through a 100-mesh sieve, 3.3g of tartaric acid, 15g of low-substituted hydroxypropyl cellulose, 30g of starch and 18g of talcum powder, and put them into a tablet machine to compress into tablets to obtain tablet A;

[0042] 2) After dissolving 0.02 g of lemon yellow with a small amount of purified water, add 8 g of starch, then add a small amount of purified water and stir evenly, then add boiling purified water, continue stirring until the slurry is cooked, and prepare 10% starch slurry;

[0043] 3) Pass 100g of heavy magnesium carbonate and 50g of aluminum glyoxate through a 40-mesh sieve, mix evenly with 15g of starch, add the starch slurry in step 2), wet granulate, and pass through a 16-mesh sieve for granulation. Dry at a temperature of ℃, and when the moisture content of the granules is ≤ 3%, stop heating...

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PUM

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Abstract

The invention relates to a method for preparing a compound aspirin double-layer tablet. The method is characterized in that aspirin, tartaric acid, low-substituted hydroxypropyl cellulose, starch and talcum powder are prepared into a first layer, and while heavy magnesium carbonate, dihydroxyaluminium aminoacetate, starch, lemon yellow and talcum powder are prepared into a second layer, and then the first layer and the second layer are pressed into the tablet. The compound aspirin tablet prepared by the method is smooth in surface, free of layering, and high in stability.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a method for preparing bilayer almagnesium tablets. Background technique [0002] Aspirin has antipyretic, analgesic, anti-inflammatory, inhibits platelet aggregation, and prevents thrombosis. Aspirin blocks the synthesis of thromboxane A2, damages the gastric mucosa, and causes mild erosion of the gastric mucosa to form ulcers, bleeding, and perforation. Therefore, once an ulcer is formed after taking aspirin, severe bleeding is prone to occur. Alkaline drugs are anti-acid and gastric mucosal protective agents, which have astringent effect, can form a protective film on the ulcer surface, promote the healing of the ulcer surface, and can also neutralize gastric acid and reduce flatulence. Therefore, compound preparations composed of high-dose aspirin and basic drugs have antipyretic, analgesic, and anti-inflammatory effects, and compound preparations composed of low-dose asp...

Claims

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Application Information

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IPC IPC(8): A61K33/10A61K9/24A61P29/00A61P7/02A61P1/04A61K31/616
CPCA61K9/2086A61K31/198A61K31/616A61K33/10A61K47/38A61K2300/00
Inventor 刘群谈宗华昝琼刘明莉孙化富
Owner TIANSHENG PHARMA GROUP
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