Controlled release tinidazole ointment suitable for being orally administered

A technology of tinidazole and ointment, applied in the field of sustained and controlled release tinidazole ointment, which can solve the problems of cumbersome nano-liposome preparation process, foreign body sensation on periodontal strips, and difficult removal, etc., and achieve long-term maintenance Effects of topical administration, relieving disease, and improving drug release performance

Active Publication Date: 2015-02-25
大连科翔科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Topical periodontal medication mainly uses antibiotics such as nitroimidazoles and minocycline, and the dosage forms include periodontal oral patches, periodontal strips, and mouthwash liquid preparations. These dosage forms mainly have the following problems: 1) Periodontal There is a foreign body sensation when the strip is used, it is hard and uncomfortable
2) The periodontal oral patch is one piece of gum, twice a day, and the sticking property is poor in the oral environment
3) The local residence time of other liquid mouthwash preparations is short, frequent administration is required, and patient compliance is poor
However, the preparation process of nanoliposomes prepared by patent CN102166191A is cumbersome, and an organic solvent is used in the middle, which is not easy to remove, and cannot be directly administered locally in the oral cavity, and cannot be used immediately

Method used

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  • Controlled release tinidazole ointment suitable for being orally administered
  • Controlled release tinidazole ointment suitable for being orally administered
  • Controlled release tinidazole ointment suitable for being orally administered

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Put 70g of petrolatum and 7g of glyceryl behenate in a beaker and stir evenly, heat the above matrix to a viscous fluid state, add 5g of sucrose fatty acid ester (HLB=15) and 8g of hydroxypropyl methylcellulose in turn and stir uniformly, add 10 g of ground tinidazole and stir evenly, then heat the above mixture to a viscous fluid state and knead to obtain an ointment.

Embodiment 2

[0034] Put 75g of petrolatum and 5g of glyceryl behenate in a beaker and stir evenly, heat the above matrix to a viscous fluid state, add 6g of sucrose fatty acid ester (HLB=15) and 10g of hydroxypropyl methylcellulose to it and stir uniformly, add 4 g of ground tinidazole and stir evenly, then heat the above mixture to a viscous fluid state and knead to obtain an ointment.

Embodiment 3

[0036] Put 85g of petrolatum and 3g of glyceryl behenate in a beaker and stir evenly, heat the above matrix to a viscous fluid state, add 4g of sucrose fatty acid ester (HLB=15) and 5g of hydroxypropyl methylcellulose in turn and stir uniform, add 3 g of ground tinidazole and stir evenly, then heat the above mixture to a viscous fluid state and knead to prepare an ointment.

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Abstract

The invention relates to a controlled release tinidazole ointment suitable for being orally administered, belonging to the technical field of pharmaceutical preparations. According to the controlled release tinidazole ointment, sucrose fatty acid ester, hydroxypropyl methyl cellulose, behenic acid glyceride and vaseline are taken as ointment matrixes and are mixed and ground together with tinidazole to form the non-corrosion controlled release tinidazole ointment with good heat stability; the ointment swells under in vitro release conditions that the temperature is 37 DEG C and the rotation speed is 100rpm and releases medicine at a zero level or an approximate zero level for a long time; vaseline has good adaptability to human tissues, is clinically used for treating tissue injury and has the effect of promoting wound healing; sucrose fatty acid ester can absorb body fluid so that the combined matrixes swells to form medicine release channels; behenic acid glyceride has good biocompatibility, and after behenic acid glyceride is mixed with vaseline, the heat stability of the ointment is increased; by virtue of adhesive effect of hydroxypropyl methyl cellulose, the corrosion of the matrixes is avoided and the release of the medicines is promoted. The controlled release tinidazole ointment can be injected to a periodontal pocket of an oral cavity.

Description

technical field [0001] The invention relates to a slow-controlled release tinidazole ointment suitable for oral administration, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Sustained-release preparations are the third-generation dosage forms developed on the basis of the concept that the curative effect of drugs is only related to the drug concentration in the body and has nothing to do with the time of administration. Sustained and controlled release preparations can reduce the fluctuation of blood drug concentration, reduce the number of administrations, improve the curative effect, reduce adverse reactions, and are easy to use, so they are more and more widely concerned by people. Traditional pharmacological studies have shown that: cardiovascular diseases, asthma, gastric acid secretion, arthritis, migraine, etc. have a circadian rhythm, such as asthma, myocardial infarction, etc., often occur in the early morning, an...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/4164A61K47/26A61K47/38A61K47/44A61K47/14A61P1/02
Inventor 汪晴李晓晖黄慧青翟琳琳
Owner 大连科翔科技开发有限公司
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