Gastric floating preparation for treating poultry proventriculitis and preparation method thereof

Abstract

The invention discloses a gastric floating preparation for treating poultry proventriculitis. The preparation comprises major medicines and excipients, wherein the major medicines are amoxicillin and astragalus polysaccharide. The preparation comprises the following raw materials in percentage by weight: 5-30% of amoxicillin, 2-10% of astragalus polysaccharide, 10-20% of an adsorbent, 20-50% of a hydrophilic gel material, 5-20% of a bleaching aid, 1-30% of a thinner and 0.2-5% of a foaming agent. The gastric floating preparation disclosed by the invention is an intra-gastric floating preparation which is prepared by combining amoxicillin and astragalus polysaccharide, so that medicines can stay in the stomach for a relatively long time to take efficacies. Compared to a normal preparation, the preparation disclosed by the invention can keep stable plasma concentration of the medicines in a body for a long time and improve bioavailability of the medicines; meanwhile, administration frequency and dosage are reduced; and toxic and side effects of the medicines as well as antibiotic residue are relieved.

Description

technical field [0001] The invention belongs to the technical field of medicines for poultry, and in particular relates to a gastric floating preparation for treating poultry glandular gastritis and a preparation method thereof. Background technique [0002] At present, poultry glandular gastritis is a common and frequently-occurring disease in poultry, especially broiler chickens. The cause of the disease is firstly that the pH value of the gastric juice decreases, which leads to a large number of Helicobacter pylori proliferation, and the strong acidity burns the glandular stomach and gizzard, which in turn causes inflammation, and in severe cases, bleeding and ulcers; secondly, viral factors, such as avian infectious bronchitis virus, poultry Influenza virus, etc. can cause glandular stomach disease; in addition, Candida albicans infection and some immunosuppressive diseases are also the causes of the disease. The mortality rate of poultry gland gastritis is as high as 1...

AI Technical Summary

Problems solved by technology

Amoxicillin has a good killing effect on the bacteria that cause glandular gastritis, but due to the short emptying time of the stomach of chickens, it is difficult to fully exert the drug effect, and the discharged drugs lead to waste and environmental pollution, and the treatment effect is poor. , it is easy to lead to slow growth and development, lower feed conversion rate, lower feed intake and resistance of sick birds, and become dead chickens, which are prone to secondary diseases and bring great economic losses to farmers.