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A kind of thermosensitive bisphenol A imprinted polymer microsphere and its application

A technology of imprinted polymers and temperature-sensitive bisphenols, which is applied in the fields of materials science and engineering and environmental science, can solve the problems that the recognition performance is difficult to fully exert, the BPA adsorption capacity is small, and there is no good carrier load, etc., to achieve good solution temperature response, Improve the adsorption capacity, the effect of simple and novel principle

Active Publication Date: 2016-08-24
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also some shortcomings that limit its further application. For example, the use of a single recognition monomer generally has a small adsorption capacity for BPA; without a good carrier, the recognition performance is difficult to fully exert, and the imprinted product is unstable and cannot be used for a long time. Preservation; the recognition and adsorption effect of imprinted polymers on BPA can only be effective in the ideal single-factor solution state, and the effect is poor or even ineffective for mixed solutions of different temperatures and different components

Method used

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  • A kind of thermosensitive bisphenol A imprinted polymer microsphere and its application
  • A kind of thermosensitive bisphenol A imprinted polymer microsphere and its application
  • A kind of thermosensitive bisphenol A imprinted polymer microsphere and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0031]a. Synthesis of polystyrene seed microspheres: Add 100mL of absolute ethanol, 20mL of deionized water and 0.7g of polyvinylpyrrolidone into a 250mL three-neck flask, then disperse them evenly by ultrasonic and constant stirring, and then slowly add 5mL Styrene was blown under nitrogen for 30 minutes, then 40 mg of azobisisobutyronitrile was added, and the temperature of the mixed solution was raised to 60° C. and maintained, and then polymerized under nitrogen protection for 24 hours. The obtained polystyrene microsphere product was washed successively with deionized water and absolute ethanol six times respectively, and the obtained product was vacuum-dried at 40° C. to constant weight, and collected for future use.

[0032] b. Synthesis of hollow porous polystyrene microspheres: Add 0.125g of sodium dodecylsulfonate and 50mL of deionized water into a 100mL two-necked flask, shake until completely dissolved and add 0.2g of the polystyrene synthesized above Seeds, consta...

Embodiment 2

[0040] Weighed 20 mg of T-MIPs and T-NIPs samples respectively, placed them in six 10 mL test tubes with ground stoppers, and added 2 mL of BPA and its five structural analogues (β-estradiol , estriol, estrone, cholesterol and phenol) in acetonitrile solution, shaking at room temperature for 24h. Then the mixture was centrifuged, filtered with a 0.45 μm microporous membrane, and the concentration of BPA and its structural analogues in the filtrate was measured by HPLC-UV, and the imprinted products were calculated accordingly. The adsorption capacity was measured 3 times in parallel for each experiment. As a control, 20 mg of T-NIPs was weighed for the same experiment. The result is as Figure 4 As shown, the adsorption capacity of T-MIPs to BPA was significantly higher than that of the other 5 kinds of phenolic substances, indicating that there were specific sites in T-MIPs and had high selectivity to BPA; There is no significant difference in the adsorption capacity of th...

Embodiment 3

[0042] Weigh 10 mg of T-MIPs and T-NIPs samples respectively, add them to 2.0 mL of solutions containing different concentrations of BPA (1, 10, 30, 50, 100 mg / L), place them in 5 mL stoppered glass test tubes, and transfer them immediately Put it into constant temperature water baths at 20, 33 and 50°C, after 24 hours of full adsorption, quickly filter and centrifuge, and filter with a 0.45 μm microporous membrane, the BPA concentration in the filtrate is quantified by HPLC-UV, and the three temperatures are evaluated The change of BPA adsorption capacity of imprinted polymer. Each group of experiments was measured 3 times in parallel. The result is as Figure 5 As shown, the adsorption of T-MIPs and T-NIPs to different concentrations of BPA has a certain response to the temperature change; at the lower critical temperature (LCST) of 33 °C, T-MIPs has the best adsorption effect on template molecules , indicating that the imprinted polymer layer is in a stretched state; at 2...

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Abstract

The invention belongs to the fields of material science and engineering and environmental science, and specifically relates to a temperature-sensitive bisphenol A imprinted polymer microsphere and an application thereof. The microspheres use polystyrene as a carrier, bisphenol A (BPA) as a template molecule, combined with temperature-sensitive material monomers, and polymerize to obtain temperature-responsive BPA imprinted polymer microspheres. The temperature-sensitive bisphenol A imprinted polymer microsphere is used for the detection of bisphenol A. The present invention has clear principle, novel design, low cost and simple operation, adopts methods such as dispersion polymerization, swelling polymerization and precipitation polymerization, and the obtained imprinted polymer microspheres have regular morphology and stable properties, and the adsorption rate of bisphenol A is fast and binding It has high capacity, good specificity and good reproducibility. When applied to the detection of seawater / yogurt samples containing bisphenol A, it can achieve a recovery rate of more than 90% and has good reusability. In addition, the smart imprinted polymer obtained in the present invention is sensitive to external temperature, and different solution temperatures have a great influence on its adsorption capacity.

Description

technical field [0001] The invention belongs to the fields of material science and engineering and environmental science, and specifically relates to a temperature-sensitive bisphenol A imprinted polymer microsphere and an application thereof. Background technique [0002] The chemical name of bisphenol A (BPA) is 2,2-bis(4-hydroxyphenyl)propane. It is an important organic chemical raw material and is widely used in plastics and resin products, antioxidants and reaction initiators. About 5% of BPA products are used in food packaging, and flow into the water environment through industrial, agricultural and urban wastewater, becoming a major source of pollution. BPA has become a common endocrine disrupting estrogen in daily life. Studies have confirmed that long-term exposure to excessive levels of BPA can interfere with the balance of the human endocrine system and cause a series of health problems, and its low-dose hazards have also attracted attention. Therefore, there is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F257/02C08F220/56C08F226/06C08F222/38C08F222/14C08F2/44C08J9/28G01N33/00G01N1/40
Inventor 李金花董瑞晨陈令新
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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