Absorbable orthopedic device material with antibacterial and bone growth promoting functions and preparation method
A technology of bone growth and orthopedics, which is applied in the field of orthopedic devices, can solve the problems of bone growth promotion function and bactericidal effect, and achieve the effect of excellent loading effect and bone growth promotion
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Embodiment 1
[0024] The absorbable bone nail with antibacterial and bone growth-promoting functions is composed of medical pure magnesium rods and absorbable polymers. There is a porous ceramic layer on the surface of pure magnesium. The surface of the porous ceramic layer is B-type gelatin The carrier and the functional loading layer loaded with bone morphogenetic protein and copper ions by electrophoresis-electrodeposition method, the preparation process is as follows:
[0025] 1) processing a pure magnesium rod with a diameter of 5 mm into a bone screw with threads and nuts;
[0026] 2) Perform micro-arc oxidation treatment on magnesium bone nails. The main components of the electrolyte are 10g / L sodium silicate, 2g / LNaOH and 8g / L hydroxyapatite nanoparticles, the magnesium nails are immersed in it, and a voltage of 420V is applied for 15 minutes of micro-arc oxidation treatment to make the surface A layer of porous ceramic layer rich in magnesium oxide, magnesium silicate and hydroxya...
Embodiment 2
[0031] The absorbable bone plate with antibacterial and bone growth-promoting functions is composed of medical AZ31B magnesium alloy plate and absorbable polymer. The surface of AZ31B magnesium alloy has a porous ceramic layer, and the surface of the porous ceramic layer is B-type gelatin As a carrier, the electrophoresis-electrodeposition method is used to load the functional loading layer of bone morphogenetic protein and copper ions. The preparation process is as follows:
[0032] 1) AZ31B magnesium alloy is hot-rolled or cut into a 1.0mm thick plate, and the bone plate with the required shape and structure is machined;
[0033] 2) Phosphating the surface of the magnesium alloy bone plate, the solution is NH 4 h 2 PO 4 120g / L, (NH 4 ) 2 SO 3 ·H 2 O30g / L, ammoniacal liquor (30%) 6mL / L, generate the porous ceramic layer based on the phosphate of magnesium, the average pore size of ceramic layer is 10 μ m, and average layer thickness is 30 μ m;
[0034] 3) Dissolve 2g o...
Embodiment 3
[0038] The absorbable orthopedic device with antibacterial and bone growth-promoting functions is composed of medical AZ31B magnesium alloy wire and absorbable copolymer of polylactic acid and polyglycolic acid (PLGA). The surface of the magnesium alloy wire has a porous ceramic layer. The surface of the porous ceramic layer is a functional loading layer with B-type gelatin as a carrier and loaded with bone morphogenetic protein and copper ions by electrophoresis-electrodeposition method. The preparation process is as follows:
[0039] 1) AZ31B magnesium alloy is drawn into a wire with a diameter of 0.3mm;
[0040] 2) Perform micro-arc oxidation treatment on the magnesium wire. The main components of the electrolyte are 10g / L sodium silicate and 2g / LNaOH. The magnesium wire is immersed in it, and a voltage of 380V is applied for 10 minutes of micro-arc oxidation treatment, so that a layer rich in magnesium oxide is formed on the surface in situ. , Magnesium silicate porous ce...
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