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Micro-emulsion containing enramycin and preparation method thereof

A technology of enramycin and microemulsion, applied in the field of enramycin-containing microemulsion and preparation thereof, can solve the problems such as the inability of the drug to dissolve completely, and the result cannot be obtained, and achieves the improvement of bioavailability, the saving of organic solvents, low cost effect

Active Publication Date: 2014-08-06
ZHEJIANG GONGSHANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2. According to the enramycin solution prepared by the solution preparation method, the drug can not be completely dissolved, and the solution is in a turbid state. After centrifugation, the supernatant is clarified, and most of the drug is precipitated at the bottom of the test tube, so the solution cannot be obtained. The results described in the patent

Method used

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  • Micro-emulsion containing enramycin and preparation method thereof
  • Micro-emulsion containing enramycin and preparation method thereof
  • Micro-emulsion containing enramycin and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0039] The compatibility test (1) of embodiment 1 enramycin microemulsion auxiliary material

[0040] Get the surfactant of 47% (w / w) and the oily phase of 25% (w / w) and evenly mix to obtain mixed solution a, the enramycin (purity 98%) of 3% (w / w) is added into 25% (w / w) of co-surfactant is uniformly mixed to obtain mixed solution b, mixed solution a and mixed solution b are uniformly mixed to obtain enramycin microemulsion concentrate, and enramycin microemulsion concentrate droplet Add it to water, wherein the volume ratio of enramycin microemulsion concentrate to water is 1:50, stir at 37°C and 100r / min for 30 minutes, and observe its milking condition. And its emulsification is divided into 5 grades: (A) the solution is clear or slightly bluish; (B) slightly turbid, blue-white; (C) bright white opaque liquid; (D) dark, off-white ,

[0041] Slightly oily; (E) Difficult to emulsify, with oil droplets always present.

[0042] Table 1 Compatibility test of enramycin microem...

Embodiment 2

[0044] The compatibility test of embodiment 2 enramycin microemulsion auxiliary materials (two)

[0045] Get the surfactant of 50% (w / w) and the oily phase of 23% (w / w) and evenly mix to obtain mixed liquid a, the enramycin (purity 95%) of 3% (w / w) is added into 24% (w / w) of co-surfactant is uniformly mixed to obtain mixed solution b, mixed solution a and mixed solution b are uniformly mixed to obtain enramycin microemulsion concentrate, and enramycin microemulsion concentrate droplet Add it to water, wherein the volume ratio of enramycin microemulsion concentrate to water is 1:500, stir at 37°C and 100r / min for 30 minutes, and observe its milk formation. And its emulsification is divided into 5 grades: (A) the solution is clear or slightly bluish; (B) slightly turbid, blue-white; (C) bright white opaque liquid; (D) dark, off-white , slightly oily; (E) difficult to emulsify, there are always oil droplets.

[0046] Table 2 Enramycin microemulsion auxiliary material compatibil...

Embodiment 3

[0049] The compatibility test (three) of embodiment 3 enramycin microemulsion auxiliary material

[0050]Get the surfactant of 52% (w / w) and the oily phase of 23% (w / w) and evenly mix to obtain mixed solution a, the enramycin (purity 90%) of 3% (w / w) is added into 22% (w / w) of co-surfactant is uniformly mixed to obtain mixed solution b, mixed solution a and mixed solution b are uniformly mixed to obtain enramycin microemulsion concentrate, and enramycin microemulsion concentrate droplet Add it to water, wherein the volume ratio of enramycin microemulsion concentrate to water is 1:1000, stir at 37°C and 100r / min for 30 minutes, and observe its milk formation. And its emulsification is divided into 5 grades: (A) the solution is clear or slightly bluish; (B) slightly turbid, blue-white; (C) bright white opaque liquid; (D) dark, off-white , slightly oily; (E) difficult to emulsify, there are always oil droplets.

[0051] Among them, the oil phase was tested with ethyl oleate, is...

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Abstract

The invention relates to the technical field of veterinary drugs, and aims to provide a micro-emulsion containing enramycin and a preparation method thereof. The micro-emulsion containing enramycin is a water-in-oil type micro-emulsion formed by mixing enramycin micro-emulsion concentrate and water in a volume ratio of (1:50)-(1:1000). The method for preparing the micro-emulsion containing enramycin comprises the following steps: mixing a surfactant and an oil phase to obtain a mixed liquid a, adding enramycin into a co-surfactant, mixing to obtain a mixed liquid b, and mixing the mixed liquid a and the mixed liquid b to obtain the enramycin micro-emulsion concentrate; dropwise adding the concentrate into water, and stirring to obtain the micro-emulsion containing enramycin. According to the micro-emulsion, the water-in-oil micro-emulsion is adopted as a carrier of a hydrophobic medicine at good drug dispersion, is an ideal carrier of insoluble medicines, can be used for prolonging the releasing time of water soluble medicines to play a sustained release effect. The preparation method is simple in production process, convenient to prepare and low in cost.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a microemulsion containing enramycin and a preparation method thereof. Background technique [0002] Enramycin is fermented by actinomyces (Streptomyces fungicidious). It is a cyclic polypeptide composed of 13 different types of 17 amino acid molecules and unsaturated fatty acid molecules. The fatty acid molecules are connected to the terminal aspartic acid. According to the difference of the terminal fatty acid molecule, it is divided into enramycin A and enramycin B. Enramycin is white or slightly yellowish white powder, the crude product is gray or taupe powder with special odor; decomposes at 234-238°C, easily soluble in dilute hydrochloric acid, slightly soluble in water, methanol, ethanol, insoluble in acetone. Enramycin has strong activity against Gram-positive bacteria, especially against harmful Clostridia in the intestine, and it is not easy to develop drug...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K38/10A61K47/40A61K47/34A61K47/14A61P31/04
Inventor 陈敏王宏刘蕊
Owner ZHEJIANG GONGSHANG UNIVERSITY
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