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Non-ionic surface active agent vesicle capable of restoring skin micro-ecology and preparation method thereof

A non-ionic surface and micro-ecological technology, applied in skin care preparations, pharmaceutical formulations, local antibacterial agents, etc., can solve problems such as poor stability, loss of cosmetic product attributes, and deterioration of finished product appearance, so as to enhance stability and change And improve the skin micro-ecological environment, the effect of large-scale industrial production convenience

Active Publication Date: 2014-04-30
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the active ingredients of coconut milk freeze-dried powder, burdock fruit extract, and linseed extract all contain various polyphenols and flavonoids, and their stability in an aqueous environment is poor. , due to oxidation, the appearance will change from light yellow to dark brown within 30 days, and the application in the formula will cause the appearance of the final product to deteriorate and lose the product attributes of cosmetics

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for preparing nonionic surfactant vesicles capable of restoring skin microecology, comprising the following steps:

[0035] A: Weigh 0.2g coconut milk freeze-dried powder, 0.6g burdock fruit extract, 0.2g linseed extract, mix the above three substances, add 60g diglycerin solution, heat to 70°C and stir with a stirrer at low speed, until completely dissolved.

[0036] B: Weigh 1.0g of polyglycerol-10 dilaurate, 1.0g of sorbitan palmitate, and 1.0g of dicetyl phosphate, mix them in advance, heat to 80°C and stir at a low speed until they are completely dissolved.

[0037] C: Mix the ingredients obtained in the above steps A and B with a stirrer at low speed, and then add 36g of deionized water,

[0038] After incubating at 75°C for 10 minutes, cool to room temperature, and add an appropriate amount of preservative to obtain non-ionic surfactant vesicles that restore skin microecology. The non-ionic surfactant vesicles containing coconut milk freeze-dried powde...

Embodiment 2

[0040] A method for preparing nonionic surfactant vesicles capable of restoring skin microecology, comprising the following steps:

[0041] A: Weigh 2.0g coconut milk freeze-dried powder, 2.0g burdock fruit extract, 6.0g linseed extract, mix the above three substances, add to 10g propylene glycol solution, heat to 75°C and stir with a stirrer at low speed until completely dissolved.

[0042] B: Weigh 5.0g of polyglyceryl-10 dilaurate, 3.0g of sorbitan palmitate, and 2.0g of dicetyl phosphate, mix them in advance, heat to 80°C and stir at a low speed until they are completely dissolved.

[0043] C: Mix the ingredients obtained in the above steps A and B with a stirrer at low speed, and then add 70g of deionized water,

[0044] After incubating at 75°C for 10 minutes, cool to room temperature, and add an appropriate amount of preservative to obtain non-ionic surfactant vesicles that restore skin microecology. The non-ionic surfactant vesicles containing coconut milk freeze-dri...

Embodiment 3

[0046] A method for preparing nonionic surfactant vesicles capable of restoring skin microecology, comprising the following steps:

[0047] A: Weigh 5.0g coconut milk freeze-dried powder, 3.0g burdock fruit extract, 12.0g linseed extract, mix the above three substances, add 20g butanediol solution, heat to 75°C and stir with a stirrer at low speed until completely dissolved.

[0048] B: Weigh 10.0g of polyglyceryl-10 dilaurate, 6.0g of sorbitan palmitate, and 4.0g of dicetyl phosphate, mix them in advance, heat to 80°C and stir at a low speed until they are completely dissolved.

[0049] C: Mix the ingredients obtained in the above steps A and B with a stirrer at low speed, and then add 40g of deionized water,

[0050] After incubating at 75°C for 10 minutes, cool to room temperature, and add an appropriate amount of preservative to obtain non-ionic surfactant vesicles that restore skin microecology. The non-ionic surfactant vesicles containing coconut milk freeze-dried powd...

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PUM

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Abstract

The invention relates to a non-ionic surface active agent vesicle capable of restoring skin micro-ecology. The vesicle is characterized by comprising the following components by weight percent: 0.1% to 40% of a non-ionic surface active agent, 0.1% to 40% of an active composition for restoring skin micro-ecology, and 1.0% to 60% of water soluble alcohol. The invention also discloses a preparation method of the vesicle. The method comprises the following steps: A, mixing the active composition for restoring skin micro-ecology and the water soluble alcohol, heating to 70 to 80 DEG C, and stirring until the mixture is completely dissolved; B, preparing an non-ionic surface active agent composition; C, mixing the substance obtained from step A and the substance obtained from step B, adding a proper amount of deionized water, performing thermal insulation for 10 minutes at the temperature of 70 to 80 DEG C, cooling, and adding a proper amount of an anti-corrosive agent. The vesicle and the preparation method have the advantages that three types of active substances, namely coconut freeze-dried powder, burdock extract and flaxseed extract, can be simultaneously coated; the normal flora micro-ecology of skin can be restored; the stability of active substances is improved, and the transdermal effect is good.

Description

technical field [0001] The invention relates to a nonionic surfactant vesicle capable of restoring skin microecology and a preparation method thereof, which can be applied in the field of cosmetics. Background technique [0002] The skin, as an ecosystem, is the habitat on which the microbial flora depends. About one billion bacteria per square centimeter peacefully coexist on the surface of the skin, forming a skin micro-ecological barrier. The resident bacteria on the skin surface include the inherent microbial populations such as Staphylococcus epidermidis and Propionibacterium acnes. Under normal circumstances, they are symbiotic and harmless to the host. Transient bacteria such as Staphylococcus aureus, Pseudomonas, Enterobacter, etc. cannot survive permanently on the skin surface, and can survive for several hours or days as the environment changes. Resident bacteria and transient bacteria are harmless to the human body when the skin hygiene habits are good, the norm...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K8/02A61K8/55A61K8/37A61Q19/00A61P31/02
Inventor 蒋丽刚毕永贤
Owner PROYA COSMETICS
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