Novel application of drug composition

A composition and drug technology, applied in the field of new uses of compound pharmaceutical compositions, can solve problems such as obstacles to transport, increase in demand, influence on lipoprotein synthesis, etc., and achieve the effects of clear drug efficacy and high efficiency

Inactive Publication Date: 2014-04-02
SICHUAN XUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

②Alcohol increases the demand for choline, and the lack of phospholipids affects the synthesis of lipoproteins, thus hindering the export
[0008] Simple direct contact of bile with gastric mucosa generally does not cause damage, but it can stimulate the secretion of gastric acid. The combination of bile salt and gastric acid can enhance the activity of acid hydrolytic enzymes, destroy lysosomes, dissolve lipoproteins in the membrane and destroy the barrier function of gastric mu...

Method used

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  • Novel application of drug composition
  • Novel application of drug composition
  • Novel application of drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 medicine of the present invention

[0032] 1. Prescription:

[0033] 173g of ox gall water, 115g of fire salt, 133g of gallinaceous gold (stir-fried), 52g of citrus aurantii (stir-fried with bran), 68g of Cyperus cyperi (made), 34g of woody fragrance, 34g of Corydalis (made with vinegar), 21g of Coptis chinensis, Atractylodes macrocephala (stir-fried with bran) ) 68g, Evodia (stir-fried) 27g, galangal 41g, hawthorn (stir-fried) 68g, Jianqu 141g, Qingpi 34g;

[0034] Excipients: starch 20g, magnesium stearate 5g.

[0035] The above raw and auxiliary materials are made into 1000 tablets of the medicine of the present invention.

[0036] 2. Process and operation

[0037] (1) Mix fried chicken neijin, Jianqu and fire salt, crush according to the "Technical Safety Operation Method for Crushing Posts", pass through a 120-mesh sieve, and fine powder for later use.

[0038] (2) Take green bark, woody fragrance, Atractylodes macrocephala, Citr...

Embodiment 2

[0053] The preparation of embodiment 2 medicines of the present invention

[0054] a. Weigh the raw materials with the following weight proportions: 300g of ox gallbladder water, 150g of fire salt, 200g of gallinaceous gold, 90g of Citrus aurantium, 100g of Cyperus cyperi, 50g of woody incense, 55g of Corydalis Corydalis, 40g of Coptidis Rhizome, 120g of Atractylodes macrocephala, 45g of Evodia rutaecarpa, Galangal 80g, Hawthorn 120g, Jianqu 200g, Qingpi 60g; (The raw materials can use processed products or not)

[0055] b. Take gallinaceous gold and fire salt and grind them into fine powder, set aside;

[0056] c. Take Jianqu and grind it or extract it with heated water to obtain hot water extract;

[0057] d. Heat the ox gall water to boiling, filter, and concentrate the filtrate to obtain a clear paste;

[0058] e. Extract volatile oil from green bark, woody scent, Atractylodes macrocephala, Citrus aurantii, Cyperus cyperi, Evodia rutaecarpa, and galangal by steam distill...

Embodiment 3

[0060] Embodiment 3 preparation of medicine of the present invention

[0061] a. Weigh the following raw materials in the following weight ratio: 150g of ox gall water, 100g of fire salt, 100g of gallinaceous gold, 30g of Citrus aurantium, 30g of Cyperus cyperi, 20g of woody fragrance, 20g of Corydalis Corydalis, 10g of Coptidis Rhizome, 40g of Atractylodes macrocephala, 10g of Evodia rutaecarpa, Galangal 20g, Hawthorn 40g, Jianqu 120g, Qingpi 20g;

[0062] b. Take gallinaceous gold and fire salt and grind them into fine powder, set aside;

[0063] c. Take Jianqu and grind it or extract it with heated water to obtain hot water extract;

[0064] d. Heat the ox gall water to boiling, filter, and concentrate the filtrate to obtain a clear paste;

[0065] e. Extract volatile oils from green bark, woody scent, Atractylodes macrocephala, Citrus aurantii, Cyperus cyperi, Evodia rutaecarpa, and galangal by supercritical flow. The volatile oils are encapsulated with β-cyclodextrin, a...

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PUM

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Abstract

The invention provides application of a drug composition to preparation of drugs for treating fatty liver. The drug composition is prepared from the following raw materials by weight: 150-300 parts of ox-gall water, 100-150 parts of potassium nitrate, 100-200 parts of endothelium corneum gigeriae galli, 30-90 parts of fructus aurantii, 30-100 parts of rhizoma cyperi, 20-50 parts of costustoot, 20-55 parts of rhizoma corydalis, 10-40 parts of coptis chinensis, 40-120 parts of white atractylodes rhizome, 10-45 parts of fructus evodiae, 20-80 parts of galangal, 40-120 parts of hawthorn, 120-200 parts of Jianqu (a traditional Chinese medicine) and 20-60 parts of pericarpium citri reticulatae viride. A clinical test and an animal drug effect test prove that the drug composition can be used for treating alcoholic fatty liver and is high in effective rate, and a new choice of drug is provided for clinic tests due to the use of the drug composition.

Description

technical field [0001] The invention relates to a new application of a compound drug, in particular to an application in preparing a drug for treating fatty liver, and belongs to the field of drugs. Background technique [0002] Fatty liver refers to the pathological changes caused by excessive accumulation of fat in liver cells due to various reasons. Fatty liver disease is a serious threat to the health of Chinese people, becoming the second largest liver disease after viral hepatitis, and has been recognized as a common cause of hidden cirrhosis. Fatty liver is a common clinical phenomenon rather than an independent disease. Its clinical manifestations are asymptomatic in mild cases, and violent in severe cases. Generally speaking, fatty liver is a reversible disease, early diagnosis and timely treatment can often return to normal. According to its etiology, it can be divided into: obesity fatty liver, alcoholic fatty liver, rapid weight loss fatty liver, malnutrition ...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K9/20A61K9/16A61K9/48A61K9/08A61P1/16A61K35/37A61K33/00A61K35/413A61K35/57
Inventor 谢李李伟张文杰
Owner SICHUAN XUHUA PHARMA
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