Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel application of tetrahydrocurcumin

A technology of tetrahydrocurcumin and uses, applied in the field of tetrahydrocurcumin, can solve the problems of type 2 diabetes, high blood sugar, and there is no report that tetrahydrocurcumin treats obese type 2 diabetes, etc., and achieves the effect of clear drug effect

Inactive Publication Date: 2010-06-16
SICHUAN ACAD OF CHINESE MEDICINE SCI
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Insulin resistance and insulin secretion defects are the basis of type 2 diabetes. Although the initial pancreatic β cells can compensate for insulin resistance, the blood sugar concentration can still maintain normal, but when the body cannot compensate for the rise in blood sugar caused by insulin resistance, the blood sugar continues to be high. within the normal range, eventually leading to type 2 diabetes
[0013] At present, there is no relevant report on the use of tetrahydrocurcumin for the prevention and / or treatment of metabolic syndrome, and there is no report that tetrahydrocurcumin can be used for the treatment of obese type 2 diabetes

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel application of tetrahydrocurcumin
  • Novel application of tetrahydrocurcumin
  • Novel application of tetrahydrocurcumin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 4

[0028] The preparation of embodiment 1 tetrahydrocurcumin compounds

[0029] through as figure 1 The synthetic route realizes the synthesis of various derivatives of tetrahydrocurcumin (curcuma longa diphenylheptanes with different double bonds, related glucuronic acid conjugates, sulfonates of glucuronic acid conjugates, etc.). This process involves three key issues: selectivity in the synthesis of various polysubstituted aldehydes; selective deprotection after full condensation of ethyl acetoacetate; and selection of hydrogenation sites in the conversion of curcumin analogues to various degrees of hydrogenation products. Due to the discovery of Lewis acid selective removal of aromatic ring hydroxyl protecting groups and multiple substitution methods of aromatic aldehydes in the past research, there are many options for solving the first and second key problems. As for the third problem, it can be realized or controlled by reduction in different stages, or by selection of d...

Embodiment 2 4

[0030] Embodiment 2 Tetrahydrocurcumin (THC) is to the effect of normal mouse appetite, body weight, blood sugar and blood fat

[0031] Experiments were performed after KM mice were adaptively fed for 3 days. Sixty mice were randomly divided into 5 groups according to fasting blood glucose level, 12 mice in each group. Establish normal control group, three dosage groups of THC (5,15,50mg / Kg), positive control group (glibenclamide 25mg / Kg), each group adopts isovolumic concentration ig administration (normal control group is given Equal volume 0.5% sodium carboxymethyl cellulose), THC three concentrations are respectively 0.05%, 0.15%, 0.5%; Positive drug concentration 0.25%. Once a day, regular administration, for 5 consecutive days. Observation indicators and detection methods: 1. Body weight (BW) was measured at a fixed time before administration and on the 5th day after administration; 2. Food intake (FI) was measured by reduction method, once a day; 3. Fasting blood gluc...

Embodiment 3 4

[0045] Embodiment 3 Tetrahydrocurcumin (THC) is to the effect of experimental metabolic syndrome rat

[0046] Experiments were carried out after SD rats were fed adaptively for 7 days. 80 rats were randomly divided into 2 groups according to body weight: 10 rats in the normal control group and 70 rats in the model group. The normal control group was fed with 4% Tween-80, and the model group was fed with fat emulsion (formula: lard 20%, cholesterol 4%, bile salt 1%, white sugar 20%, salt 8%, propylthiouracil 1%, vomiting Warm -80 4%), gavage volume 1ml / 100g·BW, qd. After 6 consecutive weeks, the rats were fasted for 16 hours, and the model group was intraperitoneally injected with STZ 30mg / kg (prepared with pH 4.2, 0.1mol / L citric acid buffer solution, protected from light and ice bathed, ready to use), and the normal group An equal volume of citrate buffer was injected intraperitoneally, with an injection volume of 0.5ml / 100g·BW. After injection of STZ, the model group cont...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides application of tetrahydrocurcumin in preparing a medicament for preventing or / and treating a set of clinical syndromes which are characterized by aggregating a variety of metabolic disturbances in an individual, such as obesity, hypertension, abnormal blood fat, abnormal saccharometabolism, has specific medicinal effect, and is a new treatment medicament which can simultaneously and effectively correct a variety of clinical disturbance factors of MS clinically.

Description

technical field [0001] The present invention relates to a new application of tetrahydrocurcumin, in particular, an application in the preparation of medicines for preventing or / and treating metabolic syndrome. Background technique [0002] There is no unified and accepted definition of metabolic syndrome (Metabolic Syndrome, MS) in the world. It is generally believed that MS is caused by the combined effects of multiple genes and various environmental factors. Abnormal and central obesity as the main connotation, insulin resistance as the common pathological basis, and a group of clinical syndromes that seriously affect human health with the clinical characteristics of a variety of metabolic diseases. At present, about 1 / 4 to 1 / 3 of the adults in the world are affected by MS. With the aging of the population and the prevalence of overweight and obesity, its incidence and prevalence are increasing year by year. In the past 20 years, the prevalence of MS in the United States ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/12A61P3/00A61P3/04A61P9/12A61P3/06A61P3/10
Inventor 赵军宁鄢良春
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com