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Total flemingia philippinensis flavonoid extract and extracting method and medicinal application thereof

A technology of jackpot and total flavonoids, which is applied in the field of preparation of Chinese medicine extracts, to achieve the effects of fast reaction or extraction, high yield and low operating cost

Inactive Publication Date: 2013-02-27
JILIN INST OF CHEM TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no reports based on heat reflux extraction, microwave-assisted extraction, ultrasonic-assisted extraction, and macroporous resin resin purification, so that the total flavonoid content in the effective part of the jackfruit is greater than 50%; there is no report about the total flavonoid content in the effective part of the jackfruit Research reports on the medicinal use of 50% extract

Method used

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  • Total flemingia philippinensis flavonoid extract and extracting method and medicinal application thereof
  • Total flemingia philippinensis flavonoid extract and extracting method and medicinal application thereof

Examples

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preparation example Construction

[0026] (1) Preparation of reference substance solution: precision takes 5.0 mg of rutin standard substance in a 50mL volumetric flask, dissolves with 70% ethanol, and constant volume is the rutin reference substance solution of 0.1mg / mL;

[0027] (2) Preparation of the test solution: Accurately weigh 20 mg of the total flavonoids extract of Echinococcus vinifera in a 25 mL volumetric flask, add 70% ethanol to dissolve, constant volume, and shake well;

[0028] (3) Drawing of standard curve: Precisely draw 0, 1, 2, 3, 4, 5 mL of standard solution, put them in 10 mL volumetric flasks respectively, add 70% ethanol solution to make 7 mL, and precisely add 0.3 mL of 5% sodium nitrite , shake well, let stand for 6min, precisely add 0.3mL of 10% aluminum nitrate solution, shake well, let stand for 10min, add 2mL of 1mol / L sodium hydroxide solution, dilute to the mark with 70% ethanol respectively, shake well, let stand for 10min, set ratio In the color dish, measure the absorbance at...

experiment example 1

[0040] Experimental Example 1 Experiment on the effect of DLP on blood lipids in hyperlipidemia model mice.

[0041] 1. Experimental materials

[0042] 1. Animals Wistar rats, 120, male and female, weighing 180-210g. Purchased from the Animal Experiment Center of Jilin University School of Basic Medicine, animal certificate number: SCXK-(Ji)-2007-0003;

[0043] 2. Drugs and reagents Qianjinba total flavonoid extract (total flavonoid content 62%, properties: light brown powder, slightly gas, slightly astringent, slightly bitter. Batch number: 20100601), provided by the Department of Pharmacy, Jilin Institute of Chemical Technology; Xuezhikang Capsules, Produced by Beijing Beida Weixin Biotechnology Co., Ltd., product batch number: 20100206; fenofibrate, produced by Liboforni Pharmaceutical Company, France, batch number: 1026396; cholesterol, specifications: biochemical reagents, Tianjin Guangfu Fine Chemical Research Institute, batch number: 100516 ; sodium cholate, specifica...

experiment example 2

[0057] Experimental Example 2 The effect of DLP on thrombus in hyperthrombotic model mice.

[0058] 1. Experimental materials

[0059] 1. Animals Wistar rats, 120, male and female, weighing 180-210g. Purchased from the Animal Experiment Center of Jilin University School of Basic Medicine, animal certificate number: SCXK-(Ji)-2007-0003;

[0060] 2. Drugs and reagents Reagents: adenosine diphosphate (ADP), Sigma Company; Danshen Tablets, produced by Shanghai Leiyunshang Pharmaceutical Co., Ltd., each tablet contains 1g of crude drug; normal saline, hypotonic saline (0.5%), produced by this The laboratory prepared by itself; sodium citrate (AR), Tianjin Damao Chemical Reagent Factory; povidone iodine solution, Jilin Star Medical Disinfection Equipment Factory; heparin, Jiangsu Jiangshan Pharmaceutical Co., Ltd., batch number 2010010; penicillin sodium for injection ( 1.6 million units), North China Pharmaceutical Co., Ltd., batch number: P0606203, prepared as an injection solut...

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Abstract

The invention relates to a total flemingia philippinensis flavonoid extract and an extracting method and medicinal application thereof, and belongs to an extract in an active medicinal part of a Chinese medicament and an extracting method and medicinal application of the extract. The method comprises the following steps of: drying and crushing flemingia philippinensis serving as a Chinese medicament, performing reflux extraction, microwave aided extraction or ultrasonic aided extraction by using 40 to 85 percent ethanol, filtering, concentrating, drying to obtain a crude total flemingia philippinensis flavonoid extract, separating and purifying with AB-8 macroporous resin, collecting the eluent, recovering the solvent, and thus obtaining the total flemingia philippinensis flavonoid extract for new Chinese medicament research, wherein the total flavonoid content measured by adopting ultraviolet spectrophotometry is more than 50 percent. The purified total flemingia philippinensis flavonoid extract has the effects of treating diseases such as hyperlipidemia and thrombus.

Description

technical field [0001] The invention belongs to a preparation method of a traditional Chinese medicine extract and a medicinal use thereof, and in particular relates to an extract of total flavonoids from qianjinba, an extraction method thereof and a medicinal use thereof. Background technique [0002] Qianjinba belongs to the subfamily Papilionoideae of Leguminosac, and is widely distributed in the southeast, south-central, and southwest regions of China. The root of Qianjinba is used as medicine, which has the effect of dispelling rheumatism and strengthening the waist and knees. It is used for rheumatoid arthritis, lumbago and leg pain, lumbar muscle strain, leucorrhea, and bruises. "Dictionary of Chinese Medicine" records that "Qianjinba tastes sweet and pungent, slightly bitter, mild in nature, non-toxic, has the effects of dispelling wind and dampness, eliminating blood stasis and detoxification, and can treat rheumatic arthralgia, chronic nephritis, bruises, carbuncle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P3/06A61P7/02
Inventor 陈帅王慧竹王晓林薛健飞刘立业年晓莉
Owner JILIN INST OF CHEM TECH
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