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Dracocephalum moldavica extract and preparation method and application thereof

An extract, the technology of Xiangqinglan, applied in the field of Xiangqinglan extract and its preparation, can solve the problems of loss of active ingredients, large dosage of Yixin Badiran Jibuya granules, and poor compliance, so as to reduce the dosage volume effect

Active Publication Date: 2016-01-20
XINJIANG INST OF MATERIA MEDICA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention provides a kind of sweet green orchid extract and its preparation method and application, which overcomes the deficiencies of the above-mentioned prior art, and it can effectively solve the problem of existing sweet green orchid During the preparation process of orchid extract, a large amount of active ingredients are lost, and the dosage of Yixin Badiran Jibuya Granules is large, resulting in poor compliance

Method used

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  • Dracocephalum moldavica extract and preparation method and application thereof
  • Dracocephalum moldavica extract and preparation method and application thereof
  • Dracocephalum moldavica extract and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0031] Example 1, the sweet green orchid extract, luteolin-7- O-β The mass percentage content of -D-glucuronide is 8.0% to 9.0%, apigenin-7- O-β -The mass percentage of D-glucuronide is 2.0% to 3.0%, the mass percentage of rosmarinic acid is 8.0% to 11.3%, diosmin-7- O-β -The mass percentage of D-glucuronide is 7.0% to 8.6%, the mass percentage of sarcoside is 13.0% to 17.0%, acaciacin-7- O-β - The mass percentage of D-glucuronide is 10.0% to 13.5%; the mass percentage of total flavonoids is 50.3% to 58.5%.

Embodiment 2

[0032] Example 2, the sweet green orchid extract is obtained according to the following preparation method: the first step, after taking an appropriate amount of sweet green orchid and pulverizing it to obtain the sweet green orchid medicinal powder, the water or volume percentage of the sweet green orchid medicinal powder is 30% to 60% The ethanol aqueous solution is refluxed for 1 to 2 times, the temperature of each reflux extraction is 30°C to 70°C, and the time of each reflux extraction is 3h to 6h, and the amount of water or ethanol aqueous solution is xiangqinglan medicinal powder 30 to 60 times the weight, and reflux the extraction to combine the extracts to obtain an extraction mixture; in the second step, concentrate the extraction mixture to 5 to 25 times the weight of the Chinese herbal medicine powder to obtain the first concentrated solution. Add absolute ethanol to the concentrated solution to obtain a mixed solution, the mass percentage of ethanol in the mixed ...

Embodiment 3

[0033] Embodiment 3, as an optimization of the above-mentioned embodiment, the sweet green orchid is the aerial part of the sweet green orchid, and the sweet green orchid medicinal material powder is the coarsest powder of the sweet green orchid.

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Abstract

The invention relates to the technical field of dracocephalum moldavica extracts and provides a dracocephalum moldavica extract and a preparation method and application thereof. The mass percentage of total flavone in the dracocephalum moldavica extract is 50.3-58.5%. The content of total flavone in the dracocephalum moldavica extract is substantially increased compared with the content of total flavone in an existing dracocephalum moldavica extract. The high dose group and the medium dose group of the dracocephalum moldavica extract have a better curative effect on myocardial ischemia compared with heart-benefiting BaDiRanJiBu subgrains. It is shown that the dracocephalum moldavica extract has a certain protective effect on myocardial ischemia injuries of rats. The dose of the medium dose group of the dracocephalum moldavica extract and the dose of the low dose group of the dracocephalum moldavica extract are 25% and 12.5% of the taking dose of the dracocephalum moldavica extract respectively, and therefore the dose is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of orchid orchid extract, and relates to an orchid orchid extract and its preparation method and application. Background technique [0002] Coronary heart disease is the most common cardiovascular disease among middle-aged and elderly people. For nearly half a century, cardiovascular disease has become the "first killer" that threatens human life and health, and coronary heart disease is the most important "culprit". Coronary heart disease is called "the plague of the times" in many developed countries, accounting for the first cause of death. In some developing countries including China, the number of morbidity and death is gradually increasing, and it is rapidly approaching developed countries. The morbidity and mortality of coronary heart disease in my country did not increase very fast before the reform and opening up, but in the past two decades, there has been an accelerated upward trend. [0003] Cor...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P9/10
Inventor 邢建国何承辉于宁姜雯刘宣麟茹仙古丽·依明
Owner XINJIANG INST OF MATERIA MEDICA
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