A dry suspension formulation containing decoquinate and its preparation method

Abstract

The invention relates to a dry suspension formulation containing decoquinate and a preparation method thereof, which includes a solid dispersion carrier, a wetting agent, a diluent, a sweetener, and a suspending agent, and is prepared by a special process into a uniform The decoquinate dry suspension dispersed in water for chicken drinking water administration. The invention has the advantages of simple preparation process, stable quality, good suspension effect in water, good palatability and the like. Compared with the premix, it also has the advantages of fast onset of action, high bioavailability, and convenient use.

Description

technical field [0001] The invention relates to a dry suspension formulation, in particular to a decoquinate dry suspension with anticoccidial effect that can be uniformly suspended in water and used for clinical drinking water administration and a preparation method thereof. Background technique [0002] Chicken coccidiosis is a kind of protozoan disease caused by a variety of Eimeria coccidia parasitizing in the epithelial cells of the small intestine and cecum of chickens. It is one of the main diseases that endanger the chicken industry at present. Chicken coccidiosis has the following characteristics: one is ubiquitous and occurs widely. Chicken coccidia are a parasite with a global distribution. It can almost be said that wherever chickens are raised, there is chicken coccidiosis. According to literature reports, the incidence rate of chicken coccidiosis in the world is as high as 50% to 70%, and the mortality rate when chicken coccidiosis breaks out reaches 20% to 3...

AI Technical Summary

Problems solved by technology

Second, it is dangerous

This process requires heating and melting or adding organic solvents, and also requires a drying process, which is complicated to produce and high in cost, which is not conducive to large-scale production

[0017] "Anticoccidial drug decoquinate dry suspension for livestock and poultry and its preparation method (CN101559074B; publication date: October 21, 2009)" involves a drying process, and the production process is relatively complicated

The product made by this patent is simply mixed with a surfactant, and suspended in water by the suspending effect of the surfactant. According to the Chinese Pharmacopoeia standard, the sedimentation ratio is less than 0.93, and the suspension effect is relatively poor. The poultry administration method is For group administration, the amount of water mixed with drinking water is large, and the suspension effect of the drug is more stringent. Although the product made by the process provided by this patent meets the requirements according to the Chinese Pharmacopoeia, it is difficult to achieve the ideal when drinking water administration. Suspension effect, easily lead to uneven distribution of drugs in water, affecting chicken drinking water administration effect

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