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Composition comprising an extract of herbal combination thereof for preventing and treating diabetes mellitus

A technology for diabetes and complications, applied in the directions of medical preparations containing active ingredients, drug combinations, plant/algae/fungus/moss ingredients, etc., can solve the problem of no disclosure of the effect of preventing and treating diabetes, etc.

Inactive Publication Date: 2011-03-23
DAI HAN PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, there is no disclosure of the anti-diabetic effect of any compound crude drug extract composed of balsam pear, cordyceps sinensis, digupi, mulberry cortex, ghost arrow feather, kudzu root, sealwort, Atractylodes macrocephala, Radix broadleaf, dogwood, and ginseng.

Method used

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  • Composition comprising an extract of herbal combination thereof for preventing and treating diabetes mellitus
  • Composition comprising an extract of herbal combination thereof for preventing and treating diabetes mellitus
  • Composition comprising an extract of herbal combination thereof for preventing and treating diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0059] (1) Prepare bitter melon extract

[0060] Take the pulp (1kg) and core (1kg) of bitter gourd, remove impurities, wash with water, and then pulverize into particles with a size of 100-400 mesh to make powder. After extracting in 20 l of 95% ethanol for 48 hours, the extract was dried under reduced pressure at room temperature to obtain 30 g of the active ingredient as a yellow powder.

[0061] (2) Preparation of Cordyceps sinensis extract

[0062] Take 1kg of Beauveria bassiana Cordyceps sinensis, remove impurities, wash with water, chop finely and soak in 20l of water at room temperature for 2 hours, decoct at 80°C for 3 hours, decoct in 15l of water for the second time for 1.5 hours, and decoct for the third time in 15l of water Boil in 15l of water for 1 hour.

[0063] The extract obtained by the above-mentioned repeated heating three times was concentrated under reduced pressure under a temperature environment of 80° C., refined, and then freeze-dried to obtain 10 ...

preparation example 1

[0247] [Preparation Example 1 of Health Supplement Composition] Drinking Agent

[0248] After mixing the composition 100mg and liquid oligosaccharide (oligosaccharide) 25g for the treatment or prevention of diabetes or diabetic complications in the examples, add 200ml of purified water, fill 80ml in each plastic bag, and sterilize at 130°C for 4- In 5 seconds, the drinking potion is prepared.

[0249] [Pharmaceutical composition preparation example 1] Tablet

[0250] After mixing 100 mg of the composition for treating or preventing diabetes or diabetic complications, 100 mg of cornstarch, 50 mg of lactose, and 2 mg of magnesium stearate in the examples, tableting was carried out according to the usual tablet preparation method to prepare pharmaceutical tablets.

preparation example 2

[0251] [Pharmaceutical composition preparation example 2] Capsules

[0252] After mixing 100 mg of the composition for treating or preventing diabetes or diabetic complications, 3 mg of crystalline cellulose, 14.8 mg of lactose, and 0.2 mg of magnesium stearate in the examples, the above-mentioned ingredients were mixed according to the usual capsule preparation method, and filled into In gelatin capsules, capsules are prepared.

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Abstract

Provided is a composition for treating and preventing diabetes or diabetic complications comprising an extract of herbal combination as an effective ingredient. The composition for treating and preventing diabetes or diabetic complications includes an extract of herbal combination of bitter melon, caterpillar fungus, wolfberry tree bark, white mulberry bark, winged euonymus, kudzu root, Solomon's seal, white atractylodes rhizome, mondo grass rhizome, Japanese cornel fruit and ginseng as an effective ingredient. The composition increases secretion of insulin in a type 2 diabetic animal, improves insulin resistance and exhibits potent blood sugar-lowering and diabetic complication inhibiting activities. Further, since it is safe with natural product ingredients, it may be usefully used to prevent and improve diabetic diseases and inhibit diabetic complications.

Description

technical field [0001] The present invention relates to a compound crude drug extract as an active ingredient for preventing and treating diabetes or diabetic complications, in particular to a composition containing bitter melon, cordyceps sinensis, Digupi, Morus alba, Guijianyu, kudzu root, The compound crude drug extracts of sealwort, atractylodes macrocephala, Ophiopogon japonicus broadleaves, dogwood and ginseng as active ingredients have hypoglycemic effects and effects of inhibiting diabetic complications, and are used as a composition for preventing and treating diabetes and diabetic complications. Background technique [0002] Diabetes is the biggest disease in the 21st century. There are currently 170 million patients worldwide, and 3.2 million people die from diabetes every year. In China, the number of diabetic patients has increased by more than 12 times in the past 20 years. It is likely that 1 out of every 4 people will be diabetic in 2025, so the country is al...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K36/48C12P1/02A61P3/10A61P1/16A61P9/00A61P9/10A61P9/12A61P15/08A61P17/00A61P27/02C12R1/69
CPCA61K36/815A61K36/488A61K36/284A61K36/258A61K36/40A61K36/899A61K36/48A61K36/42A61K36/068A61K36/605A61K36/185A61P1/16A61P13/12A61P15/08A61P17/00A61P25/00A61P25/02A61P27/02A61P9/00A61P9/10A61P9/12A61P3/10A61K2300/00
Inventor 李承泳
Owner DAI HAN PHARM
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