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Anti-degradation antibacterial biological coating, and preparation method and application thereof

A bio-coating, anti-degradation technology, applied in coatings, metal material coating technology, medical science, etc., can solve the problem that Ti coatings do not have biological activity, long-term stability needs to be improved, and coatings do not have antibacterial properties and other issues, to achieve the effect of excellent biological activity and biocompatibility, good resistance to degradation, and obvious antibacterial effect

Inactive Publication Date: 2011-02-16
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these two coating materials still have deficiencies: HA coating has low bonding strength with the substrate (10-20MPa), and is easily degraded in physiological environment; Poor osteogenesis
However, the degradation rate of calcium silicate-based coatings is too fast under the erosion of physiological body fluids, and its long-term stability needs to be improved; moreover, the coatings do not have antibacterial properties, and the postoperative anti-infection ability is poor

Method used

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  • Anti-degradation antibacterial biological coating, and preparation method and application thereof
  • Anti-degradation antibacterial biological coating, and preparation method and application thereof
  • Anti-degradation antibacterial biological coating, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A. Preparation of Ca by sol-gel method 2 ZnSi 2 o 7 powder

[0024] Tetraethyl orthosilicate (TEOS), ethanol (C 2 h 5 OH), 2M nitric acid (HNO 3 ) according to the molar ratio of 1:8:0.16, after stirring at room temperature for 30 minutes, the pH value of the solution was about 1; adding Zn(NO 3 ) 2 , Ca(NO 3 ) 2 powder, where Zn(NO 3 ) 2 , Ca(NO 3 ) 2 , TEOS molar ratio is 0.5:1:1, stirred at room temperature for 5 hours to obtain a clear solution; 60 ° C for one day to obtain a wet gel; 120 ° C for two days to obtain a dry gel; 1300 ° C for 1 hour to obtain Ca 2 ZnSi 2 o 7 Powder; pass through a 80-mesh sieve, dry at 100-120°C, and set aside. 【References: Ceramics International, 2005(31), 27-31】

[0025] B. Preparation of Ca by plasma spraying technology 2 ZnSi 2 o 7 coating

[0026] After the surface of pure titanium or Ti-6Al-4V alloy is sandblasted or sanded, ultrasonically 1-2 times in absolute ethanol solution, 3-5 minutes each time, and then ...

Embodiment 2

[0030] Example 2: Ca 2 ZnSi 2 o 7 Degradation resistance test of coating

[0031] Ca 2 ZnSi 2 o 7 coating with zinc-free Ca 2 SiO 4 The coatings were respectively soaked in Tris-HCl buffer solution, and the mass loss per unit area of ​​the coatings was compared with time.

[0032] The result is as image 3 shown by image 3 Visible: soaking day 1, Ca 2 SiO 4Coating mass loss per unit area up to 15mg / cm 2 , while Ca 2 ZnSi 2 o 7 The coating is less than 3.5mg / cm 2 , significantly lower than the former; after soaking for 14 days, Ca 2 ZnSi 2 o 7 The mass loss per unit area of ​​the coating is less than 6mg / cm 2 , while Ca 2 SiO 4 Coating exceeds 25mg / cm 2 . By comparison, it can be known that doping Zn into calcium silicate-based ceramics synthesizes Ca 2 ZnSi 2 o 7 Can improve the degradability of calcium silicate based coatings.

Embodiment 3

[0033] Example 3: Ca 2 ZnSi 2 o 7 Antibacterial test of coating

[0034] The antibacterial performance of the material was quantitatively detected by the oscillation method: the standard Staphylococcus aureus was used as the test strain; the strain was inoculated on the surface of nutrient agar, and cultivated in an incubator for 18 hours; with reference to the bacterial standard turbidimetric tube, diluted to 2 × 10 8 Bacteria / ml, serially diluted 10 times to 10 -2 Bacterial solution with high concentration; after high-temperature sterilization, in a conical flask filled with 20ml of PBS, pure Ti (control piece) with a diameter of 16mm and a thickness of 2mm, Ca 2 ZnSi 2 o 7 4 coated discs each; add 0.2ml bacterial solution to the Erlenmeyer flask, shake at constant temperature for 18h. Take the liquid in 0.5ml Erlenmeyer flask respectively, carry out 10 -2 、10 -3 After dilution, 0.2ml each was inoculated into nutrient agar and cultured for 48h.

[0035] Figure 4 i...

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Abstract

The invention discloses an anti-degradation antibacterial biological coating, which is formed by spraying hardystonite powder on the surface of a pure titanium or titanium alloy matrix. By using a plasma spraying process, the coating is prepared by spraying the hardystonite powder on the surface of the processed pure titanium or titanium alloy matrix. The biological coating provided by the invention has superior bioactivity and biocompatibility, anti-degradation performance and antibacterial performance, solves the problems in the prior art and promotes the repairing of hard tissues and development of the substitutional material field; and the preparation method of the invention has the advantages of high efficiency, high repeatability, suitability for scale production and the like and is easy to operate.

Description

technical field [0001] The present invention relates to an anti-degradation and antibacterial biological coating and its preparation method and application, in particular, it relates to a zehnite coating which is sprayed on the surface of pure titanium or titanium alloy substrate by plasma spraying technology and its preparation method and applications, belonging to the technical field of medical biological coatings. Background technique [0002] Metal implants such as titanium alloy, cobalt chromium molybdenum, and stainless steel are commonly used bone implant materials in clinical practice. In order to endow metal bone implants with better biological functions and enhance their integration with bone tissue, biological coatings need to be prepared. People use various coating technologies to study biological coatings, among which the coating materials prepared by plasma spraying method are relatively successful, especially the plasma spraying titanium (Ti) and hydroxyapati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/30C23C4/12C23C4/10A61L27/54C23C4/11C23C4/134
Inventor 李恺谢有桃黄利平季珩郑学斌
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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