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Method for synthesizing superparamagnetic ferroferric oxide nano particle in situ by induction of acrylic acid polymer nano hydrogel

A nano-hydrogel, ferric tetroxide technology, applied in the direction of ferric oxide/ferric hydroxide, ferrous oxide, etc., can solve the problems of harsh reaction conditions, weak interaction force, low stability, etc. The effect of simple process, high activity and simple and easy-to-obtain equipment

Inactive Publication Date: 2011-01-05
DONGHUA UNIV
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  • Summary
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] At present, the commonly used coating methods are mainly divided into two methods: co-precipitation coating in polymer aqueous phase solution and ready-made Fe3O4 nanoparticles after polymer coating. Although the stability of nanoparticles can be improved to a certain extent and their The circulation time in the blood, but there are still three main problems: (1) the uniformity of the coated iron oxide content and the uniformity of the nanoparticles formed by coating; (2) the interaction between the polymer and the iron oxide nanoparticles The force is weak, so the stability of polymer-coated iron oxide is not high; (3) In a single coated nanoparticle, the content of magnetic iron oxide is not high, resulting in the formation of contrast agents in some environments of the human body. The image signal is not clear
Moreover, chitosan gel is made of toxic organic cross-linking agent, so it is not biocompatible
Patent CN 101612541A, although it is also coated with polyacrylic acid for the separation and purification of cell DNA, the pyrolysis method used requires relatively harsh reaction conditions, such as high temperature, protective atmosphere, etc., and requires complicated procedures such as reflux and centrifugation

Method used

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  • Method for synthesizing superparamagnetic ferroferric oxide nano particle in situ by induction of acrylic acid polymer nano hydrogel
  • Method for synthesizing superparamagnetic ferroferric oxide nano particle in situ by induction of acrylic acid polymer nano hydrogel
  • Method for synthesizing superparamagnetic ferroferric oxide nano particle in situ by induction of acrylic acid polymer nano hydrogel

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Experimental program
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Embodiment 1

[0039] The steps of this embodiment are as follows: (1) 2g hydroxypropyl cellulose (HPC) powder (average M w =1.0×10 5 ) was dissolved in 98g deionized water, magnetically stirred for 1 day, and prepared into a 2% (wt%) HPC homogeneous solution; (2) at room temperature, 5g2% (wt%) HPC solution and 0.1gBis were dissolved in 93g Deionized water, stirred for 15min; (3) Add 2g of acrylic acid and 0.05g of APS, in N 2 Stirring under protection for 45min; (4) warming up to 28°C, adding 0.05g TEMED to initiate polymerization; (5) neutralizing the prepared polyacrylic acid nanohydrogel with sodium hydroxide to pH=6 and then dialyzing for 2 days; (6 ) take 10ml polyacrylic acid nano hydrogel solution and dilute to 100ml, add 0.6gFeSO 4 ·7H 2 O powder, in N 2 Stir all night under protection and dialyze for 1 day; (7) in N 2 Add 0.03gNaNO under protection 2 powder and stirred for 2 hours, then added 5ml of ammonia water until the solution turned from green to black, took it out and...

Embodiment 2

[0041] The steps of this embodiment are as follows: (1) 2g hydroxypropyl cellulose (HPC) powder (average M w =1.0×10 5 ) was dissolved in 98g deionized water, magnetically stirred for 1 day, and prepared into a 2% (wt%) HPC homogeneous solution; (2) at room temperature, 5g2% (wt%) HPC solution and 0.1gBis were dissolved in 93g Deionized water, stirred for 15min; (3) Add 2g of acrylic acid and 0.05g of APS, in N 2 Stirring under protection for 45min; (4) warming up to 28°C, adding 0.05g TEMED to initiate polymerization; (5) neutralizing the prepared polyacrylic acid nanohydrogel with sodium hydroxide to pH=7 and then dialyzing for 2 days; (6 ) take 10ml polyacrylic acid nano hydrogel solution and dilute to 100ml, add 0.6gFeSO 4 ·7H 2 O powder, in N 2 Stir all night under protection and dialyze for 1 day; (7) in N 2 Add 0.03gNaNO under protection 2 The powder was stirred for 2 hours, then 5ml of ammonia water was added until the solution turned from green to black, and the...

Embodiment 3

[0043] The steps of this embodiment are as follows: (1) 2g hydroxypropyl cellulose (HPC) powder (average M w =1.0×10 5 ) was dissolved in 98g deionized water, magnetically stirred for 1 day, and prepared into a 2% (wt%) HPC homogeneous solution; (2) at room temperature, 5g2% (wt%) HPC solution and 0.1gBis were dissolved in 93g Deionized water, stirred for 15min; (3) Add 2g of acrylic acid and 0.05g of APS, in N 2 Stirring under protection for 45min; (4) warming up to 28°C, adding 0.05g TEMED to initiate polymerization; (5) neutralizing the prepared polyacrylic acid nanohydrogel with sodium hydroxide to pH=6 and then dialyzing for 2 days; (6 ) take 20ml polyacrylic acid nano hydrogel solution and dilute to 100ml, add 1gFeSO 4 ·7H 2 O powder, in N 2 Stir all night under protection and dialyze for 1 day; (7) in N 2 Add 0.03gNaNO under protection 2 The powder was stirred for 2 hours, then 5ml of ammonia water was added until the solution turned from green to black, and the s...

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Abstract

The invention relates to a method for synthesizing a superparamagnetic ferroferric oxide nano particle in situ by the induction of acrylic acid polymer nano hydrogel, which comprises the following steps of: with hydroxypropyl cellulose in an aqueous solution as a template, synthesizing biodegradable acrylic acid polymer nano hydrogel at first, wherein the alkali neutralized acrylic acid polymer nano hydrogel contains a great amount of negative -COO<->; adsorbing a great amount of positive Fe<2+> to enter a gel network by the interaction of static electricity; and with a gel particle as a nano reactor, internally synthesizing a ferroferric oxide nano particle in situ. The operating method of the invention is simple, convenient and easy, the prepared ferroferric oxide magnetic nano particle have favorable dispersity and intelligence, and a ferroferric oxide nano crystal has even distribution and high content in the nano hydrogel magnetic nano particle.

Description

technical field [0001] The invention belongs to the field of preparation of superparamagnetic iron ferric oxide nanoparticles, in particular to a method for synthesizing superparamagnetic iron ferric oxide nanoparticles in situ induced by acrylic polymer nano hydrogel. Background technique [0002] Bioimaging has become a new and rapidly growing field, and its importance is manifested in the fields of basic biological and medical sciences. In recent years, biomedical imaging has attracted worldwide attention due to its unique analytical and diagnostic capabilities at the molecular and cellular levels. As a result, a new discipline "molecular imaging" combining molecular biology and in vivo imaging has emerged. Representative imaging techniques include computerized tomography (CT), optical imaging, magnetic resonance imaging, positron emission tomography (PET), single photon emission computerized tomography (SPECT), and ultrasound imaging. These imaging technologies can obs...

Claims

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Application Information

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IPC IPC(8): C01G49/08
Inventor 鲁希华廖谦邱高
Owner DONGHUA UNIV
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