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Nicergoline sublingual tablet and preparation method thereof

A technology for nicergoline and sublingual tablets, applied in the field of nicergoline sublingual tablets and its preparation, can solve the problems of unsuitable for controlled release administration, high bioavailability, and small adverse reactions, and achieve proper disintegration time , High bioavailability, no gritty effect

Inactive Publication Date: 2010-05-26
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Saliva secretion: Sublingual saliva secretion is large, due to the flushing effect of saliva, it is not suitable for controlled release administration
[0012] Although Nicergoline tablets, sustained-release granules, capsules, powder injections and injections are disclosed in the prior art, there is no document disclosing Nicergoline sublingual tablets, especially good stability, little adverse reaction, Non-quick-acting nicergoline sublingual tablet that is convenient to take, has good compliance, can be released slowly, is fully absorbed in the sublingual mucosa, and has high bioavailability

Method used

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  • Nicergoline sublingual tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Nicergoline 5g

[0033] Lactose 45g

[0034] Mannitol 15g

[0035] Sodium carboxymethyl starch 0.35g

[0036] Macrogol 4000 0.65g

[0037]

[0038] Makes 1000 pieces

[0039] Preparation method: Take nicergoline raw material drug, lactose, mannitol, sodium carboxymethyl starch, and polyethylene glycol 4000 respectively, grind them separately, mix and sieve according to the above weight ratio, and put the final mixed fine powder into a new tablet press Use a powder feeder, compress into tablets, the diameter of the tablets is 5.5 mm, pack, and get ready.

Embodiment 2

[0041] Nicergoline 5g

[0042] Lactose 45g

[0043] Mannitol 15g

[0044] Sodium carboxymethylcellulose 0.35g

[0045] Macrogol 4000 0.65g

[0046]

[0047] Makes 1000 pieces

[0048] Preparation method: Weigh the raw materials of Nicergoline, lactose, mannitol, sodium carboxymethylcellulose, and polyethylene glycol 4000 respectively, grind them separately, mix and sieve according to the above weight ratio, and mix the fine powder with a new type of tablet In a machine-use powder feeder, press into tablets, the diameter of the tablets is 5.5 mm, pack, and get ready.

Embodiment 3

[0050] Nicergoline 5g

[0051] Lactose 30g

[0052] Mannitol 20g

[0053] Sucrose 10g

[0054] Sodium carboxymethyl starch 0.35g

[0055] Macrogol 4000 0.65g

[0056]

[0057] Makes 1000 pieces

[0058] Preparation method: Take nicergoline raw material drug, lactose, mannitol, sucrose, sodium carboxymethyl starch, polyethylene glycol 4000 respectively, pulverize them respectively, mix and sieve according to the above weight ratio, and put the mixed fine powder into a new press. The tablet machine uses a powder feeder, compresses the tablet, the diameter of the tablet is 5.5 mm, packs, and obtains.

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Abstract

The invention discloses nicergoline sublingual tablet and preparation method thereof. The nicergoline sublingual tablet is a sublingual mucosal administration non-quick-acting preparation prepared by comprising nicergoline raw material medicine, a filling agent, a disintegrating agent and a lubricating agent. In the sublingual tablet, the weight parts of the nicergoline is 1-20, the weight parts of the filling agent is 20-150, and the weight parts of the lubricating agent is 0.3-3.5. The nicergoline sublingual tablet has convenient use, small adverse reaction, good compliance, stable quality, slower release, sufficient absorption on the sublingual mucosa and high bioavailability.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a nicergoline sublingual tablet and a preparation method thereof. Background technique [0002] Vascular dementia (VD) has been on the rise rapidly in recent years. With the aggravation of urbanization and aging, China's elderly population has exceeded 120 million, and the incidence of geriatric diseases is also increasing year by year. With the increase of residents' income, the requirements of the elderly for the quality of life are also increased. Under this trend, the demand for therapeutic drugs for diseases such as vascular dementia has also increased significantly. VD disease is a disease with declining function and needs long-term medication. With the development of society and the improvement of people's attention to this kind of disease, the demand for therapeutic drugs is constantly increasing. According to the results of the survey of doctors, 8.16% of doc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/48A61P25/28A61J3/10
CPCB30B15/302
Inventor 刘孝乐朱丹
Owner HONGYI SCI & TECH CO LTD NANCHANG
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