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Preparation method for cerebroprotein hydrolysate freeze-dried injection for injection

A technology for cerebroprotein hydrolysate and freeze-dried powder injection is applied in the field of biological drug preparation, which can solve the problems of high technical content requirements, complex operation process, long production cycle and the like, and achieves low technical content requirements, simple operation process, The effect of short production cycle

Active Publication Date: 2010-02-03
GUANGDONG LONGFU MEDICINE CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the preparation methods of cerebroprotein hydrolyzate injection powder in these prior art have problems such as long production cycle, low output, complex operation process and high technical content requirements.

Method used

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  • Preparation method for cerebroprotein hydrolysate freeze-dried injection for injection
  • Preparation method for cerebroprotein hydrolysate freeze-dried injection for injection
  • Preparation method for cerebroprotein hydrolysate freeze-dried injection for injection

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Embodiment

[0015] 1. Prescription:

[0016] Brain Protein Hydrolyzate Solution 5000ml

[0017] (Containing 140.4-210.7g of free amino acids and 27.45-33.55g of total nitrogen)

[0018] Mannitol 400g

[0019]

[0020] Make 1000 pieces

[0021] The above-mentioned cerebroprotein hydrolyzate solution is produced by the biochemical raw material workshop of the Pharmaceutical Factory of Guangdong Institute of Materia Medica, and the trade name is cerebroprotein hydrolyzate solution; mannitol is produced by Qingdao Jiaonan Mingyue Company. However, the cerebroprotein hydrolyzate solution and mannitol involved in the present invention are not limited to those produced by the above-mentioned pharmaceutical factories, but may also be produced by other pharmaceutical factories or purchased from the market.

[0022] 2. Preparation method: weigh 5000ml of cerebroprotein hydrolyzate solution, thaw natur...

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Abstract

The invention relates to a preparation method for cerebroprotein hydrolysate freeze-dried injection for injection, which comprises the following steps: weighing 5000 volume of cerebroprotein hydrolysate solution; adding 4-10 mass / volume% of skeleton agent into the solution in the aseptic condition, and adjusting the range of Ph to be 6.9-7.5; collecting filter liquor after 0.45mum bacilli-eliminated filtration; filing and drying, wherein the drying time is sequentially 5 hours in the temperature of minus 40 DEG C, 4 hours in the temperature of minus 40 DEG C to minus 15 DEG C, 4 hours in the temperature of minus 15 DEG C to 5 DEG C, 2 hours in the temperature of minus 5 DEG C to 5 DEG C, 3 hours in the temperature of 5 DEG C to 40 DEG C, and 10 hours in the temperature of 40 DEG C; and thedrying time is totally 28 hours. The product prepared by the preparation method is stable and controllable; and the operational technique is simple.

Description

technical field [0001] The invention relates to a preparation method of biological medicine, in particular to a preparation method of cerebroprotein hydrolyzate freeze-dried powder for injection. Background technique [0002] Cerebroprotein hydrolyzate, as an active brain polypeptide substance extracted from healthy and fresh animal brain tissue by multi-enzyme hydrolysis, contains a variety of essential amino acids for human brain and important elements such as cephalin, lecithin, and peptide nerve growth factor. It acts on the central nervous system in various ways, regulates and improves the metabolism of neurons, promotes the formation of synapses, induces neuron differentiation, and further protects nerve cells from various ischemia and neurotoxin damage. It can pass through the blood-brain barrier, promote protein synthesis in the brain, affect the respiratory chain, protect against hypoxia, and improve energy metabolism in the brain. Activates adenylyl cyclase to cat...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K38/01A61K47/10A61P25/00A61P9/10A61P3/02
Inventor 张隆鑫
Owner GUANGDONG LONGFU MEDICINE CO LTD
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