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Polyolefin thermoplastic elastomer blood storage material and preparation method thereof

A thermoplastic elastomer and blood storage technology, which is applied in the field of polyolefin blended resin, can solve the problems of blood or blood component storage bag bag deformation, poor heat resistance of the material, and low bag body strength, and achieve physical and mechanical properties Excellent, avoid toxicity problems, improve the effect of mechanical properties

Inactive Publication Date: 2009-08-26
SHANDONG WEIGAO GROUP MEDICAL POLYMER +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The many deficiencies in the materials used to make blood and blood component storage containers involved in the above patents can be summarized as follows: (1) The heat resistance of the material is not good, which will make the blood or blood component storage bags deformed
However, ethylene oxide vapor is soluble in the maintenance solution, and the blood or blood component storage container products containing the maintenance solution cannot be sterilized with ethylene oxide, which greatly limits the application of these materials
(2) The mechanical properties of the material are poor
Although the strength of the blood or blood component storage bags made of these materials can meet the requirements of the national standard, the strength of the bag is still not high, and it is prone to breakage and leakage in practical applications.
(3) Small molecule ester compounds added to improve the anti-hemolysis performance of materials, such as: butyryl tri-n-hexyl citrate, citrate, will penetrate into the blood or liquid medicine, causing potential harm to the human body

Method used

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  • Polyolefin thermoplastic elastomer blood storage material and preparation method thereof
  • Polyolefin thermoplastic elastomer blood storage material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh the A1, B1 and C1 component materials according to the weight ratio of 70 / 20 / 10, pre-irradiate the B1 component with an electron beam, and the irradiation dose is 5KGy, and mix the three component materials in a high-speed mixer for 5 minutes , to obtain the premix. Add the premixed material into the reactive twin-screw extruder. The screw diameter of the extruder is 40mm, and the length-to-diameter ratio is 36. The temperature is 220°C. The blend is extruded through a die, cooled and cut into pellets to obtain a blood storage material. The test results of melt flow rate, light transmittance, haze, surface hardness and mechanical properties of special materials for liquid and blood component storage containers are listed in Table 2.

Embodiment 2

[0028] Weigh the A2, B2 and C2 component materials according to the weight ratio of 65 / 15 / 20, pre-irradiate the C2 component with an electron beam, and the irradiation dose is 10KGy, and mix the three component materials in a high-speed stirrer for 5 minutes , to obtain the premix except that the temperature of the extruder along the feed port to the die direction is set to 150-240 ° C and the die temperature is set to 230 ° C, the equipment used, processing conditions and steps are all the same as those in Example 1 Same, adopt the method identical with embodiment 1 to carry out sample preparation, and test corresponding performance index, the result is listed in table 2.

Embodiment 3

[0030] Weigh the A1, B2 and C1 component materials according to the weight ratio of 60 / 25 / 15, pre-irradiate the A1 component with γ-rays, and the irradiation dose is 3KGy, and other equipment, processing conditions and steps used are the same as the implementation Example 1 is the same, adopt the same method as Example 1 to prepare samples, and test the corresponding performance indicators, the results are listed in Table 2.

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Abstract

The invention relates to a polyolefin thermoplastic elastomer blood storage material which comprises component A, component B and component C; wherein the middle part of component A is a random copolymer segmer of ethene and 1-butylene or a random copolymer segmer of ethene and propylene, two ends are provided with a block polymer with styrene block for end capping, and the component A takes 60-76 percent of the gross weight of the material; component B is ethene-vinyl acetate (EVA) resin and takes 10-28 percent of the gross weight of the material; component C is polyethylene (PE) resin and takes 10-20 percent of the gross weight of the material. A preparation method is combining the pre-irradiation treatment of one component with a melt-blending and micro-crosslinking method to prepare the polyolefin thermoplastic elastomer blood storage material. The invention can be used for manufacturing a blood bag, a conduit, a component and the like for storing human blood and blood component. During the processing, promoters such as plasticizer, antioxidant and the like are not added, micromolecular organic substance separation and pollution of liquid medicine and blood do not occur, and the polyolefin thermoplastic elastomer blood storage material is harmless to human body and the environment.

Description

technical field [0001] The invention belongs to the technical field of polyolefin blended resins, in particular to a polyolefin thermoplastic elastomer blood storage material and a preparation method thereof. The resin can be used to make blood and blood component storage containers. Background technique [0002] We know that polyvinyl chloride (PVC) is cheap and has excellent comprehensive physical and mechanical properties. It is widely used as a material for disposable infusion sets and blood transfusion sets at home and abroad. With the extensive and in-depth clinical application and the development of related medical science and technology, people found that PVC material itself has potential safety hazards, and there are also many defects in processing and use performance. A small amount of vinyl chloride monomer will be produced in the production or processing of PVC resin, which has been proved to be a carcinogen. In order to obtain soft PVC products, plasticizers (o...

Claims

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Application Information

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IPC IPC(8): C08L53/00C08L23/08C08J3/28C08J3/24
Inventor 栾世方殷敬华王建卫杜兰平朱连超李忠志
Owner SHANDONG WEIGAO GROUP MEDICAL POLYMER
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