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Composite antibacterial drugs composition containing abafungin

The technology of an antibacterial drug, abafungin, applied in the field of preparation

Inactive Publication Date: 2009-04-01
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no literature report on the combination of abafencin and other antibacterial drugs, which can effectively treat skin and mucous membrane fungi, fungal and bacterial mixed infections

Method used

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  • Composite antibacterial drugs composition containing abafungin
  • Composite antibacterial drugs composition containing abafungin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Formula (cream): (1) Abafungin 10g, (2) Nystatin 4g, (3) Vaseline 10g, (4) Stearic acid 110g, (5) Liquid paraffin 60g, (6) Monostearin Glyceryl Acid Ester 35g, (7) Propylparaben 0.2g, (8) Stearyl Alcohol 50g, (9) Triethanolamine 4.5g, (10) Methylparaben 1.8g, (11) Di-tert-Butyl Hydroxyl Toluene 2g, (12) glycerin 40g, (13) sodium metabisulfite 10g, (14) ethylenediaminetetraacetic acid 1g, (15) add distilled water to 1000g.

[0024] Preparation method: put glycerin and sodium metabisulfite into a mortar and grind them evenly, then add abafungin and nystatin, and grind them evenly. This is ①; Vaseline, stearic acid, glyceryl monostearate, eighteen Mix alcohol, liquid paraffin, propylparaben, place in a water bath at 70-80°C to stir and dissolve, this is ②; mix methylparaben, di-tert-butylhydroxytoluene, ethylenediaminetetraacetic acid and water, Place in a water bath at 70-80°C to stir and dissolve, this is ③; add ① to ③, stir while adding, then add ②, stir until the emul...

Embodiment 2

[0026] Formula (cream): (1) Abafungin 15g, (2) Metronidazole 0.5g, (3) Lanolin 45g, (4) Acetylated monoglyceride 70g, (5) Liquid paraffin 60g, (6 ) cetyl alcohol 80g, (7) chlorhexidine gluconate 0.06g, (8) sodium sulfite 2g, (9) magnesium aluminum silicate 35g, (10) add distilled water to 1000g.

[0027] Preparation method: first mix lanolin, acetylated monoglyceride, liquid paraffin, and cetyl alcohol, put it in a water bath at 65-75°C, stir and dissolve, this is ①; add chlorhexidine gluconate, sodium sulfite, magnesium silicate Put aluminum and distilled water in a water bath at 70-80°C to stir and dissolve, this is ②; add ① while stirring ②, and set aside; mix abafungin and metronidazole, this is ③; add the above ③ in equal amounts to ①②In the mixed matrix, mix evenly, fill it up, and get it.

Embodiment 3

[0029] Recipe (suppository): (1) Abafungin 2.5g, (2) Clarithromycin 1.5g, (3) Glycerin gelatin 520g, (4) Vaseline 60g, (5) Triethanolamine 20g, (6) Dodecane Sodium sulfate 1g, (7) methyl paraben 1g, (8) propyl paraben 1g, (9) add distilled water to 1000g

[0030]Preparation method: mix glycerin gelatin and distilled water, and put it in a water bath at 50-60°C, stir, and dissolve it as ①; put petroleum jelly in a water bath at 50-60°C, dissolve it as ②; after ① and ② are dissolved , put ② into ①, stir evenly; mix abafungin with clarithromycin, triethanolamine, methylparaben, propylparaben and sodium lauryl sulfate evenly, then add to ①② mixture After stirring evenly, let it cool, and when it is close to solidification, pour it into a suitable pessary mold, overflow slightly, cool and solidify, scrape it flat, and take it out of the package.

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PUM

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Abstract

The invention relates to a compound medical combination for dermal external use and mucosa delivery which remedies fungal infection or mixed bacterial and fungal infection and contains caspofungin. The combination contains 0.1 percent to 10 percent of the caspofungin, at least 0.01 percent to 10 percent of other antibacterial drug and medical auxiliary material. The combination is particularly fit for the treatment of the patient with the mixed bacterial and fungal infection.

Description

Technical field: [0001] The invention belongs to the field of preparations, and in particular relates to a pharmaceutical composition containing abafungin and other antibacterial drugs. The pharmaceutical composition is used for treating fungal infections or mixed infections of bacteria and fungi. Background technique: [0002] Superficial fungal disease is a common disease, which is highly contagious, extremely high incidence, stubborn and easy to relapse, such as tinea pedis, i.e. beriberi, with an average incidence rate of one-third in the country, and a high incidence rate in some high-incidence areas. up to 60%. Bacterial skin infections can be classified as primary or secondary. Primary infection often has a characteristic shape and course of disease. It is initially caused by a single pathogen and occurs on normal skin. Usually, staphylococcus can easily cause impetigo, folliculitis, furuncle, carbuncle, etc. Streptococcus can easily cause erysipelas and cellulite. ...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61K9/00A61K45/06A61P31/10A61P17/00
CPCA61K31/7056A61K31/7036A61K31/7034A61K31/04A61K31/498A61K31/506A61K31/635A61K31/545A61K31/65A61K31/496A61K31/7048A61K31/43A61P17/00A61P31/04A61P31/10
Inventor 张涛李佳邹艳冶牟才华樊斌
Owner CHONGQING PHARMA RES INST
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