Method for preparing nano-micro level sun-screening agent with emulsification function

An emulsifying function, nano-micron technology, used in cosmetic preparations, skin care preparations, cosmetics, etc., can solve the problems of low disassociation rate, rapid aging of wrinkles, and increased strength.

Inactive Publication Date: 2011-09-07
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ultraviolet rays below 280nm are absorbed by the ozone layer and cannot reach the ground. However, with the increasing use of refrigeration equipment such as refrigerators and air conditioners by humans, the leakage of Freon (CFC) in the compressor is also increasing, which makes the ozone layer. Intensification, the intensity of UVC radiation on the ground tends to increase; UVB can cause erythema or blisters on the skin, promote the formation of melanin, cause skin pigmentation, and cause the formation of brown spots; the energy of UVA can reach the dermis of the skin and give blood vessels Or combined with the elastic fibers in the tissue to bring about slow changes, which will cause the browning of the skin, reduce the elasticity of the skin, promote the occurrence of wrinkles and make people age rapidly, and also promote erythema reactions and even cause phototoxicity or photosensitivity reactions
Compared with small molecule micelles, such as surfactant micelles, polymer micelles are also composed of hydrophilic and hydrophobic two parts, but their critical micelle concentration is lower, and due to the small mobility of their chain segments, their disassociation Combined rate is smaller

Method used

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  • Method for preparing nano-micro level sun-screening agent with emulsification function
  • Method for preparing nano-micro level sun-screening agent with emulsification function
  • Method for preparing nano-micro level sun-screening agent with emulsification function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: One-time feeding of dimethylaminoethyl methacrylate, 4-methyl-7-p-vinylbenzylideneoxycoumarin, and methyl methacrylate in a molar ratio of 15:15:70 , adding azobisisobutyronitrile accounting for 2% of the total molar amount of reactants to initiate, react at 60° C. for 24 hours, purify, add lactic acid for neutralization, and obtain a photosensitive amphiphilic copolymer. Dissolve the copolymer in dioxane to make a 5wt% solution, add ultrapure water dropwise to it until a blue phase appears, continue stirring at a constant speed for 2-12 hours, remove the dioxane to obtain a pure photosensitive amphiphilic copolymer Micellar aqueous solution, micellar form such as Figure 4 shown. The aqueous solution of micelles is irradiated under ultraviolet light with a wavelength of 365nm for 15-300min, the double bond in coumarin absorbs ultraviolet light and opens, and photocrosslinking occurs, and the dissociation occurs again under the ultraviolet light of 254nm for...

Embodiment 2

[0027] Example 2: N-vinylpyrrolidone and 4-methyl-7-p-vinylbenzylideneoxycoumarin were charged at one time according to the molar ratio of 50:50, and added 2% of the total molar amount of the reactants. Initiated by azobisisobutyronitrile, reacted at 80°C for 12 hours, purified, neutralized by adding lactic acid, and vacuum dried to constant weight to obtain a photosensitive amphiphilic copolymer. Dissolve the copolymer in dioxane to make a 5wt% solution, add ultrapure water dropwise to it until a blue phase appears, continue stirring at a constant speed for 2-12 hours, remove the dioxane to obtain a pure photosensitive amphiphilic copolymer Micellar aqueous solution. The aqueous solution of micelles is irradiated under ultraviolet light with a wavelength of 365nm for 15-300min, the double bond in coumarin absorbs ultraviolet light and opens, and photocrosslinking occurs, and the dissociation occurs again under the ultraviolet light of 254nm for 0.5-120min. link. Add the pol...

Embodiment 3

[0028] Example 3: Methacryloyloxyethyl trimethylammonium chloride, methacryloyloxyethyl cinnamate and methyl methacrylate were prepared in a molar ratio of 15:15:70 or 30:30:40 One feeding, adding 1% azobisisobutyronitrile to the total molar amount of reactants to initiate, react at 70° C. for 20 hours, purify, add lactic acid for neutralization, and vacuum dry to constant weight to obtain a photosensitive amphiphilic copolymer. Dissolve the copolymer in dioxane to make a 5wt% solution, add ultrapure water dropwise to it until a blue phase appears, continue stirring at a constant speed for 2-12 hours, remove the dioxane to obtain a pure photosensitive amphiphilic copolymer Micellar aqueous solution. The micellar aqueous solution is placed under a UV lamp with a wavelength of 365nm and irradiated for 15-300min. The double bond in the cinnamoyl group absorbs UV light to open, photo-crosslinking occurs, and then cyclizes to form a three-dimensional network structure. 120min will...

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PUM

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Abstract

The invention relates to a preparation method for a nano and micro sun-screening agent with emulsifying function, belonging to the photosensitive amphiphilic copolymer micelle particle preparation technical field. The method prepares the photosensitive amphiphilic copolymer micelle particle which integrates the emulsifying and sun-screening effects through self-assembly of photosensitive amphiphilic copolymer. The micelle diameters are in the nanometer range, the micelle particle can effectively absorb ultraviolet between 270 and 350 nm for photocrosslinking reaction, and can absorb the ultraviolet again when the ultraviolet is less than 260 nm after photodissociation. The micelle particle can be used as the macromolecular sun-screening agent and has the advantages of low toxicity, low permeability, good skin affinity and feeling. The copolymer micelle is not only provided with photosensitive units but also provided with hydrophilic / lyophobic microdmain, can also reduce the tension ofoil-water boundary, and has the emulsifying function. The preparation method has easily obtained monomers, simple reaction conditions and high yield, can control the macromolecular micelle particle through the self-assembly technology, and has potential application value in the cosmetics and washing product field when added with the monomers provided with functional groups.

Description

technical field [0001] The invention relates to a preparation method of a nano-micron sunscreen agent with emulsifying function, belonging to the technical field of preparation of photosensitive amphiphilic copolymer micelle particles. In the present invention, the photosensitive amphiphilic polymer micelle particles are prepared by the "green" and "clean" self-assembly technology of the amphiphilic copolymer with photosensitivity and ionicity. The assembly is controllable, the preparation process is simple and pollution-free, and it has potential application prospects in sunscreens and emulsifiers for toiletries. Background technique [0002] Ultraviolet (UVR) is a part of sunlight, which originally refers to the invisible light with wavelengths from 190nm to 400nm. Ultraviolet rays can be divided into ultraviolet short wave (UVC) 190nm ~ 280nm, ultraviolet medium wave (UVB) 280nm ~ 320nm and ultraviolet long wave (UVA) 320nm ~ 400nm. Ultraviolet rays below 280nm are abso...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F2/06C08J3/11C08J3/16C08F220/06C08F212/08C08F220/18C08F218/08C08F226/10A61K8/81A61K8/06A61Q17/04A61Q5/02
Inventor 刘晓亚边琦曹光群江金强王益华王婷立易成林朱叶
Owner JIANGNAN UNIV
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