Enteric oral vaccine for fishing gear and preparation method thereof
An oral vaccine and enteric-coated technology, which is applied in the field of fish oral vaccines, can solve the problems of destroying the immunogenicity of vaccines, lack of particles, and the inability to establish vaccine controlled release technology, etc., to efficiently stimulate immune responses, enhance adhesion firmness, and improve The effect of immune efficiency
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Embodiment 1
[0027] Preparation method: select 10-30 mesh starch granules and set aside.
[0028] The first step of vaccine spraying: the dry powder composition A is dissolved in water, and it is formulated into an aqueous suspension with a solid content of 5%, and then an appropriate amount of flounder ascites disease vaccine physiological saline solution (10 8 CFU / ml), prepared into 10 6 The suspension at the concentration of CFU / ml vaccine is evenly sprayed on the surface of the particles using a high-pressure spray gun. Vaccine spray amount 10 6 CFU / g.
[0029] The second step of coating the isolation layer: the dry powder composition A was dissolved in water to prepare a suspension with a solid content of 5%, and evenly sprayed on the surface of the vaccine layer with a high-pressure spray gun. The coating weight gain was 2%.
[0030] Dry powder composition A formula consists of:
[0031] Hypromellose E5 25g
[0032] Hypromellose E15 22g
[0033] Polyvinyl alcohol S205 13g
[...
Embodiment 2
[0070] Preparation method: select 10-30 mesh starch granules and set aside.
[0071] The first step of vaccine spraying: the dry powder composition A is dissolved in water, configured into an aqueous suspension with a solid content of 8%, and then an appropriate amount of flounder ascites disease vaccine physiological saline solution (10 10 CFU / ml), prepared into 10 7 The suspension at the concentration of CFU / ml vaccine is evenly sprayed on the surface of the particles using a high-pressure spray gun. Vaccine spray amount 10 7 CFU / g. (that is, each gram of sprayed particles contains 10 7 CFU)
[0072] The second step of coating the isolation layer: the dry powder composition A was dissolved in water to prepare a suspension with a solid content of 8%, and evenly sprayed on the surface of the vaccine layer with a high-pressure spray gun. The coating weight gain was 4%.
[0073] Dry powder composition A formula consists of:
[0074] Hypromellose E5 30g
[0075] Hypromell...
Embodiment 3
[0095] The functional dry powder film-forming composition of embodiment 3 fish enteric-coated vaccine
[0096] Preparation method: select 10-30 mesh starch granules and set aside.
[0097] The first step of vaccine spraying: the dry powder composition A is dissolved in water, configured into an aqueous suspension with a solid content of 5%, and then an appropriate amount of flounder ascites disease vaccine physiological saline solution (10 10 CFU / ml), prepared into 10 8 The suspension at the concentration of CFU / ml vaccine is evenly sprayed on the surface of the particles using a high-pressure spray gun. Vaccine spray amount 10 8 CFU / g.
[0098] The second step of coating the isolation layer: Dissolve the dry powder composition A in water to prepare a suspension with a solid content of 10%, and use a high-pressure spray gun to evenly spray it on the surface of the vaccine layer. The coating weight gain was 4%.
[0099] The formula of dry powder composition A consists of: ...
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