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Freeze-drying hepatitis A varicella attenuation combined vaccine and producing method thereof

A hepatitis A and combined vaccine technology, applied in freeze-dried delivery, antiviral agents, drug combinations, etc., to prevent hepatitis A and chickenpox, reduce market prices, and reduce adverse reactions.

Active Publication Date: 2008-09-10
长春生物制品研究所有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the use of live attenuated hepatitis A vaccine virus to produce freeze-dried hepatitis A-varicella attenuated combined vaccine

Method used

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  • Freeze-drying hepatitis A varicella attenuation combined vaccine and producing method thereof
  • Freeze-drying hepatitis A varicella attenuation combined vaccine and producing method thereof
  • Freeze-drying hepatitis A varicella attenuation combined vaccine and producing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Preparation of Freeze-dried Hepatitis A-varicella Attenuated Combined Vaccine

[0052] With the stoste of 1.2L hepatitis A vaccine virus (L-A-1 strain, virus titer is 8.0LogCCID 50 / ml) was mixed with the stock solution (6000PFU) of 2.4L varicella vaccine virus, then added the protective agent stock solution prepared as follows: protective agent component A550ml, protective agent component B600ml and protective agent component C450ml. Then, add an appropriate amount of 199 comprehensive solution as the virus vaccine matrix solution to the mixed solution obtained in this way, so that the total volume of the liquid combined vaccine reaches 7200ml, so that the hepatitis A vaccine virus titer is not less than 6.5LogCCID wherein 50 / ml, the virus titer of varicella vaccine is not less than 4000PFU / ml. As a result of such dilution, the concentration (w / v) of each component of the protective agent added in the vaccine solution reached respectively: trehalose 42g / l, dextran 18...

Embodiment 2

[0056] Preparation of Freeze-dried Hepatitis A-varicella Attenuated Combined Vaccine

[0057] With the stoste of 1.2L hepatitis A vaccine virus (L-A-1 strain, virus titer is 8.0LogCCID 50 / ml) mixed with the stock solution (6000PFU / ml) of 2.4L varicella vaccine virus, then add the protective agent stock solution prepared as follows: protective agent component A550ml, protective agent component B900ml and protective agent component C900ml. Then, add an appropriate amount of 199 comprehensive solution as the virus vaccine matrix solution to the mixed solution obtained in this way, so that the total volume of the liquid combined vaccine reaches 7200ml, so that the hepatitis A vaccine virus titer is not less than 6.5LogCCID wherein 50 / ml, the virus titer of varicella vaccine is not less than 4000PFU / ml. As a result of such dilution, the concentration (w / v) of each component of the protective agent added in the vaccine solution reached respectively: trehalose 62.5g / l, dextran 37....

Embodiment 3

[0061] Preparation of Freeze-dried Hepatitis A-varicella Attenuated Combined Vaccine

[0062] With the stoste of 2.4L hepatitis A vaccine virus (L-A-1 strain, virus titer is 8.0LogCCID 50 / ml) mixed with the stock solution (6000PFU / ml) of 2.4L varicella vaccine virus, then add the protective agent stock solution prepared as follows: protective agent component A550ml, protective agent component B900ml and protective agent component C900ml. Then, add an appropriate amount of 199 comprehensive solution as the virus vaccine matrix solution to the mixed solution obtained in this way, so that the total volume of the liquid combined vaccine reaches 7200ml, so that the hepatitis A vaccine virus titer is not less than 6.5LogCCID wherein 50 / ml, the virus titer of varicella vaccine is not less than 4000PFU / ml. As a result of such dilution, the concentration (w / v) of each component of the protective agent added in the vaccine solution reached respectively: trehalose 62.5g / l, dextran 37....

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Abstract

The present invention provides a freeze-dried hepatitis-A-chicken-pox attenuation combined vaccine and a production thereof. The combined vaccine has the security and the immunogenicity as good as the univalent vaccine and can effectively prevent the hepatitis A and the chicken pox. Two kinds of diseases can be effectively prevented just by one immunization, which can reduce vaccine cost, improve vaccine inoculation efficiency and reduce the bad reaction caused by a plurality of times of injections, and can reduce the vaccine inoculation times but realize the purpose of preventing various diseases.

Description

technical field [0001] The invention provides a freeze-dried hepatitis A-varicella attenuated combined vaccine. The invention also provides a preparation method of the combined vaccine and a protective agent for the combined vaccine, belonging to the technical field of vaccine preparation. Background technique [0002] The global application of preventive vaccines has effectively controlled infectious diseases and greatly reduced the morbidity and mortality of many common infectious diseases. With the rapid development of molecular biology, cell biology and other related disciplines, new vaccines are constantly being researched and developed. However, the increase in the types of vaccines will inevitably be accompanied by a series of problems, such as the increase in the number of vaccinations for children and the difficulty in vaccine management. Each child needs to go to the vaccination clinic as many as 20 times during the 7 years before school. This not only greatly in...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61K9/19A61P31/14A61P31/20A61P1/16A61K39/25A61K39/29
CPCY02A50/30
Inventor 赵晓琳刘令九刘景晔付炜王文忠屈翠波王玮李育红李淑焱蔡晖梁本李莉
Owner 长春生物制品研究所有限责任公司
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