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Degradable chemical bitter earth alloy bracket and method of preparing the same

A chemical oxidation and magnesium alloy technology, applied in medical science, surgical adhesives, metal material coating technology, etc., can solve the problems of high waste liquid treatment cost, containing hexavalent chromium ions, affecting alloy composition, etc., and achieve low cost , excellent mechanical and pharmacological properties, and the effect of prolonging the service life

Active Publication Date: 2008-08-27
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the process of realizing the present invention, the inventors found that there are at least the following problems in the prior art: although the traditional chromate treatment has a better effect, the process contains hexavalent chromium ions, which is highly toxic and pollutes the environment, and the treatment of waste liquid high cost
At the same time, when the magnesium alloy is chemically oxidized with a chemical oxidation solution containing heavy metal salts, when the alloy is recycled, heavy metal elements will become impurities and affect the composition of the alloy.
In order to improve the bonding force of the anti-corrosion layer, pre-plating is required, resulting in cumbersome process

Method used

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  • Degradable chemical bitter earth alloy bracket and method of preparing the same

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preparation example Construction

[0025] The flow chart of a method for preparing a degradable vascular stent with a composite coating in an embodiment of the present invention is as follows: figure 1 shown, including the following steps:

[0026] In step s101, the matrix is ​​machined into a stent, and the matrix is ​​made of pure magnesium or a magnesium alloy material. The matrix can also be processed into bone sutures, bone nails, bone connectors, vertebral discs, suture anchors, hemostatic forceps, hemostatic screws, hemostatic plates, hemostatic clips, tissue adhesives, sealants, or artificial bones.

[0027] Step s102, pretreatment of the substrate, the pretreatment includes the steps of degreasing, pickling and alkali washing to remove impurities such as grease and oxides on the surface of the magnesium alloy. The pretreatment of described substrate comprises:

[0028] Put the matrix into the degreasing liquid for degreasing, the composition of the degreasing liquid is: NaOH5~10g / L, NaOH 2 CO 3 5~1...

Embodiment 1

[0040] Example 1: After high-purity magnesium is polished, it is carved into a vascular stent with a laser. First sand with progressively finer sandpaper to mechanically remove surface oxides. Then degrease, pickle and alkali wash. The degreasing solution is NaOH 5g / L, Na 2 CO 3 5g / L and Na 2 SiO 3 5g / L. The temperature of the degreasing solution is 303K, and the time is 30 minutes; the pickling solution is a mixed solution of 20ml / L acetic acid and 5g / L sodium nitrate. The temperature of the pickling solution is 303K, and the pickling time is 3 minutes. Rinse with clean water after taking it out, and then soak the high-purity magnesium stent in alkaline washing solution. The alkaline washing solution is a sodium hydroxide solution with a pH value of 12 and 10g / L, the temperature is 303K, and the alkaline washing time is 5 minutes. After taking it out, rinse it with clean water, and then put the high-purity magnesium stent into the chemical oxidation solution.

[00...

Embodiment 2

[0046] Example 2: AZ91D magnesium alloy is polished and then laser engraved into a vascular stent. First sand with progressively finer sandpaper to remove surface oxides. Then degrease, pickle and alkali wash. The degreasing solution is NaOH 5g / L, Na 2 CO 3 5g / L and Na 2 SiO 3 5g / L. The temperature of the degreasing solution is 303K, and the time is 30 minutes; the pickling solution is a mixed solution of 20ml / L acetic acid and 5g / L sodium nitrate. The temperature of the pickling solution is 303K, and the pickling time is 3 minutes. Rinse with clean water after taking it out, and then soak the magnesium alloy stent in alkaline washing solution. The alkaline washing solution is a sodium hydroxide solution with a pH value of 12 and 10g / L, the temperature is 303K, and the alkaline washing time is 5 minutes. After taking it out, rinse it with clean water, and then put the magnesium alloy stent into the chemical oxidation solution.

[0047] The composition of magnesium m...

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Abstract

The invention discloses a degradable vascular stent with a composite coating and a preparation method thereof, and comprises a matrix made from pure magnesium or magnesium alloy material; a chemical oxide film layer that is arranged on the surface of the matrix and is used for decreasing the corrosion rate of the matrix and prolonging the service life of the matrix; a degradable polymer material layer that is located at the surface of the chemical oxide film layer and therapeutic drug that are fixed at the degradable polymer material layer. The degradable vascular stent with a composite coating of the invention has excellent mechanical and pharmacological properties, otherwise, the degradation rate of the magnesium material is reduced, and the service life of the stent is prolonged.

Description

technical field [0001] The invention belongs to the field of implanted medical devices, and relates to a degradable vascular stent with a composite coating and a preparation method thereof. Background technique [0002] Magnesium is an element with very abundant reserves, and the composition of magnesium in magnesium alloy accounts for more than 90%. The density of magnesium alloy is less than 2g / cm 3 Among practical metals, magnesium alloy has the smallest specific gravity, which is 1 / 4 of iron and 2 / 3 of aluminum; magnesium alloy has high specific strength and specific stiffness, good shock absorption performance and high temperature plasticity, and good polishing Performance, excellent thermal conductivity, electrical conductivity, electromagnetic shielding and green environmental protection, etc., are known as "green engineering materials in the 21st century". Therefore, the application of magnesium alloys in the fields of automobile manufacturing, aerospace, communica...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/10A61L31/16A61L17/10A61L24/04A61L27/54A61L27/58A61L27/42A61L27/34C23C22/57
Inventor 董飒英蒲忠杰
Owner LEPU MEDICAL TECH (BEIJING) CO LTD
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