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Cellulose/ soy protein composite sponge and preparing method thereof

A technology of soybean protein and composite sponge is applied in the fields of biomedical materials and polymers to achieve the effect of simple production process and low cost

Inactive Publication Date: 2008-03-19
常熟紫金知识产权服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there has been no report on the preparation of composite sponges with cellulose and soybean protein as the main raw materials. It is expected that in the cellulose / soy protein composite sponge, the raw materials are all non-toxic natural polymers, which can be biodegraded. The protein has the function of pore forming and biological activity and carrying cell growth factors, and both of them have good hydrophilicity and biocompatibility

Method used

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  • Cellulose/ soy protein composite sponge and preparing method thereof
  • Cellulose/ soy protein composite sponge and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1 (comparative example)

[0024] Pre-cool 7wt% sodium hydroxide / 12wt% urea aqueous solution (96.4g) to -12°C, take it out and place it at room temperature (below 20°C), quickly put 3.6g of dry cotton linter cellulose into it, and stir thoroughly A 3.6 wt% cellulose solution was prepared. After centrifugation and degassing, place it in a -20°C refrigerator, transfer it to a -80°C refrigerator after 24 hours, place it in a -80°C refrigerator for 24 hours, freeze-dry, treat with dilute acetic acid, and rinse with water to obtain pure cellulose sponge.

Embodiment 2

[0026]In 100g of the 3.6wt% cellulose solution in Example 1, add 4g of a 10wt% soybean protein solution while stirring, and continue stirring for 20min to obtain a mixed solution after the addition is complete. After the cellulose / soybean protein mixed solution was centrifuged and degassed, the cellulose / soybean protein composite sponge was prepared according to the method of Example 1. The soybean protein content in the composite sponge is 10wt%.

[0027] Fig. 1 is the SEM photograph of the sponge obtained in Example 1 and Example 2, that is, the SEM photograph of the composite sponge with 10 wt% of pure cellulose sponge and soybean protein respectively. The sponge is a porous structure with irregular pore shapes and different sizes.

Embodiment 3

[0029] The composite sponges obtained in Examples 1 and 2 were implanted into SPF grade SD rats subcutaneously and intramuscularly after conventional autoclaving, and were raised after suturing the surgical wound. The samples were taken out during the operation, and observed by light microscope and scanning electron microscope to preliminarily evaluate the biocompatibility of the material.

[0030] Fig. 2 is the light microscope pictures of the cellulose / soybean protein composite sponge obtained in this example (soybean protein solid content is 10wt%) implanted in rats for 1, 3 and 5 months respectively. After 1 month, the spongy material was clearly visible, and a small amount of cells and tissues entered the interior of the spongy material. After 3 months, part of the composite sponge still existed, but the amount of cells and tissues entering the material increased significantly. After 5 months, the composite sponge has basically disappeared, and the tissue has occupied th...

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Abstract

The invention discloses a composite sponge using cellulose and soybean protein as main raw materials and a preparation method, in which cellulose and soybean protein solves in sodium hydroxide / urea aqueous solution, and composite sponge is prepared by freeze drying and vacuum drying method. The composite material with different microstructure and performance can be prepared by changing the proportion of cellulose and soybean protein and through crosslink and modification of glutaric dialdehyde and epoxy chloropropane. The implant experiments in the body of animals and the in vitro cell culture experiments show that the composite material has good biological compatibility. The method is simple and applicable, the raw material of which has rich sources, and the method is hopeful to prepare biodegradable material for medicine from natural polymer with application foreground.

Description

technical field [0001] The invention relates to a kind of cellulose / soybean protein composite sponge, a preparation method and its application, and belongs to the field of biomedical materials and also belongs to the field of macromolecules. Background technique [0002] With the development of life science and medicine, there are more and more clinical requirements for biomedical materials, and it is of great significance to research and develop biodegradable and absorbable biomedical materials. At present, the degradable polymer materials that have been studied more are mainly synthetic polymers, such as polycaprolactone and polyglycolic acid. The application of chitosan, cellulose, protein and other natural polymers and their derivatives in biomedicine is also attracting more and more attention. Among them, cellulose is the most abundant renewable resource in nature and has good potential uses in the field of biomedicine. Cellulose and its derivatives are excellent tiss...

Claims

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Application Information

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IPC IPC(8): C08L1/02C08L89/00C08J3/24C08K5/07C08K5/15
Inventor 陈云张俐娜罗丽花王小梅
Owner 常熟紫金知识产权服务有限公司
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