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Natural amphoteric polyelectrolyte electric field sensitive aqueous gel and preparation method thereof

A polyelectrolyte and hydrogel technology, applied in the field of natural amphoteric polyelectrolyte electric field sensitive hydrogel and its preparation, can solve the problem of limiting the application range of electric field sensitive hydrogel, limiting hydrogel application, biocompatibility and problems such as poor biodegradability, to achieve good biocompatibility and biodegradability, high environmental friendliness and biosafety, and low prices

Inactive Publication Date: 2008-02-06
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the raw materials for the preparation of electric field-sensitive hydrogels are synthetic polymers or blends of synthetic polymers and natural polymers (such as polyacrylic acid, sulfonated polystyrene, and polyethylene glycol and chitosan co-polymers). Due to the poor biocompatibility and biodegradability of most synthetic polymers, the application of this type of hydrogel in biomedicine is greatly limited.
On the other hand, most of the electric field-sensitive hydrogels reported so far have only one kind of charge, so under electrical stimulation, they can only move in one direction in an electrolyte solution within a certain pH range (acidic or alkaline). bending, this limitation also limits the application range of electric field-sensitive hydrogels
In addition, the mechanical properties, fatigue life and response speed of electric field-sensitive hydrogels need to be further improved.

Method used

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  • Natural amphoteric polyelectrolyte electric field sensitive aqueous gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Add 2% carboxymethylcellulose solution dropwise to 2% chitosan solution under low-speed stirring at 40°C, then add a small amount of hydrochloric acid to dissolve a small amount of white precipitate generated, and finally obtain a transparent and uniform Blending solution, wherein the mass ratio of chitosan to carboxymethyl cellulose is 3:2. Stirring was continued at 40°C for 60 min, and then the blend was cast into a box made of polyester film, and dried at room temperature to form a film. The prepared membrane was treated in 1% sodium hydroxide solution for 6 h, then rinsed with deionized water until neutral, and dried at room temperature.

[0018] Soak the dried membrane in a buffer solution with an ionic strength of 0.1 and a pH value of 5.0 for 4 hours to reach swelling equilibrium. Then cut the hydrogel membrane into 10×2×0.2mm 3 The gel strip is vertically placed between two parallel electrodes with a distance of 5cm in the above buffer solution, and...

Embodiment 2

[0020] Example 2: Add 4% carboxymethyl cellulose solution dropwise to 4% chitosan solution under low-speed stirring at 60°C, then add a small amount of hydrochloric acid to dissolve a small amount of white precipitate generated, and finally obtain a transparent and uniform Blending solution, wherein the mass ratio of chitosan to carboxymethyl cellulose is 3:2. Epichlorohydrin whose mass is 0.02 times that of carboxymethyl cellulose was added as a crosslinking agent, and after stirring at 60°C for 120 min, the blend was cast into a box made of polyester film, and dried at room temperature to form a film. The prepared membrane was treated in 2% sodium hydroxide solution for 2 h, then rinsed with deionized water until neutral, and dried at room temperature.

[0021] Soak the dried membrane in a buffer solution with an ionic strength of 0.1 and a pH value of 6.0 for 4 hours to reach swelling equilibrium. Then cut the hydrogel membrane into 10×2×0.2mm 3 The gel strip is verticall...

Embodiment 3

[0022] Example 3: Add 1% carboxymethyl cellulose solution dropwise to 1% chitosan solution under low-speed stirring at 80°C, then add a small amount of hydrochloric acid to dissolve a small amount of white precipitate generated, and finally obtain a transparent and uniform Blending solution, wherein the mass ratio of chitosan and carboxymethyl cellulose is 7:3. After continuing to stir at 80°C for 30 min, the blend was cast into a box made of polyester film, and dried at room temperature to form a film. The prepared membrane was treated in 0.5% sodium hydroxide solution for 12 h, then rinsed with deionized water until neutral, and dried at room temperature.

[0023] Soak the dried membrane in a buffer solution with an ionic strength of 0.1 and a pH value of 7.0 for 4 hours to reach swelling equilibrium. Then cut the hydrogel membrane into 10×2×0.2mm 3 The gel strip is vertically placed between two parallel electrodes with a distance of 5 cm in the above buffer solution, and ...

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Abstract

The present invention belongs to the natural macromolecule materials technical field, in particular to a natural polyampholyte electric field sensitive hydrogel and preparation method. The present invention adopts the blending of natural cationic polyelectrolyte and natural anionic polyelectrolyte, both of which are characterized by good biological compatibility and biological degradation, to prepare natural polyampholyte hydrogel film. Natural polyampholyte hydrogel film is immersed in electrolytic solution and bends under the role of direct current field. The bending direction and bending angle of hydrogel film can be adjusted. The hydrogel film has electric field response in electrolytic solution with varied pH value; and bends toward different directions under acid condition and alkali condition. The properties expand the scope of pH value for electric field sensitive hydrogel; thus leading to bright prospect of widespread application of electric field hydrogel in fields like artificial muscle, sensor, controlled drug release, automatic switch components and separation technology.

Description

technical field [0001] The invention belongs to the technical field of natural polymer materials, and in particular relates to a natural amphoteric polyelectrolyte electric field sensitive hydrogel and a preparation method thereof. Background technique [0002] Hydrogel refers to a cross-linked polymer with a three-dimensional network structure that contains a large number of hydrophilic groups in the main chain or branch chain and absorbs a large amount of water. It swells in water but does not dissolve. It contains a lot of water and can maintain a certain shape. Under the stimulation of external physical and chemical factors, such as temperature, pH, light, electricity, magnetism, sound, force, chemical substances, etc., some Polymer hydrogels can undergo reversible changes in volume and shape. Such hydrogels that are stimuli-responsive to changes in the external environment are called environment-sensitive hydrogels or smart hydrogels. [0003] In various external stimu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J5/18C08L5/08C08L1/26
Inventor 陈新尚婧邵正中
Owner FUDAN UNIV
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