Chiral composition containing dextrothyroxine buprofenli and levomethadyl cysteliqin and its double slow-releasing tablet

Abstract

The invention is concerned with a kind of chiral compound and its sustained and controlled release double deck pieces compound with (S)-ibuprofen and levocetirizine. The weight ratio of the both is 50:1 to 500:1, and the said troche has two layers and one layer is the sustained and controlled release part made of (S)-ibuprofen, levocetirizine dihydrochloride and acceptable rapidly release assistant stuff. It can collapse quickly to be absorbed by body to take effect and work with antipyretic and analgesic effects, lighten sneezing, nasal stiffness and rhinocnesmus. The other layer is controlled release layer made on (S)-ibuprofen and acceptable controlled release assistant stuff. It can release with sustained and controlled in body to keep the concentration of blood and medicine in body of (S)-ibuprofen and work with antipyretic and analgesic effects to reduce the symptom of cold.

Description

technical field [0001] The present invention relates to a kind of pharmaceutical composition for treating common cold, especially a kind of composition containing dexibuprofen or its pharmaceutically acceptable salt and levocetirizine dihydrochloride, the weight ratio range of the two is 50:1 to 500:1, made into an oral sustained-rapid release double-layer tablet suitable for taking. Background technique [0002] Ibuprofen is a phenylpropionic acid non-steroidal antipyretic, analgesic and anti-inflammatory drug. Receptivity is good. Pseudoephedrine has the effect of selectively constricting blood vessels, which can eliminate congestion and swelling of nasopharyngeal mucosa and relieve nasal congestion symptoms. Therefore, ibuprofen and pseudoephedrine often form compound oral preparations and are widely used in the treatment of symptoms such as fever, headache, sore limbs, and nasal congestion caused by colds. [0003] However, the safety of ibuprofen oral preparations st...

AI Technical Summary

Problems solved by technology

Although both chlorpheniramine and loratadine can effectively relieve runny nose and sneezing caused by colds, these two antihistamines are ineffective for nasal congestion. As a last resort, it is necessary to combine adrenaline-like nasal congestion relievers, such as Clariflu (contains acetaminophen, loratadine, pseudoephedrine)

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