Coenzyme Q10 emulsion and its freeze dried prepn and their prepn process

A technology of freeze-dried emulsions and auxiliary emulsifiers, which can be used in pharmaceutical formulations, emulsion delivery, and medical preparations of non-active ingredients. and other issues to achieve good stability

Inactive Publication Date: 2007-11-07
姚瑶 +1
View PDF6 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007]Coenzyme Q10 has low solubility in water, so it is difficult to make injections directly. Currently, the clinically used coenzyme Q10Injections are generally solubilized by non-aqueous solvents and a large amount of surfactants, which may cause adverse reactions such as allergies and hemolysis af...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Coenzyme Q 10 The composition of the emulsion is: Coenzyme Q 10 0.25g, soybean oil 10g, purified egg yolk lecithin 1.2g, glycerol 2.5g, and the rest water for injection, 100ml in total.

[0057] Coenzyme Q 10 The emulsion preparation process is as follows:

[0058] Coenzyme Q 10 Add soybean oil until completely dissolved, then add purified egg yolk lecithin and shear and stir evenly to obtain an oil phase; dissolve glycerin in water for injection at 40°C to obtain a water phase; add the water phase to the oil phase and stir for 30 minutes To obtain colostrum, adjust the pH value to 5.5-7.0, pass the colostrum through a high-pressure homogenizer, first adjust the pressure of the homogenizer to 5000psi and repeat the homogenization for 3 times, then adjust the pressure of the homogenizer to 15000psi, and repeat the homogenization for 3 to 5 times , Measure the particle size of the emulsion to obtain a uniformly dispersed emulsion with a particle size of 10 Emulsion...

Embodiment 2

[0060] Coenzyme Q 10 The composition of the emulsion is: Coenzyme Q 10 0.25g, medium chain oil 10g, purified egg yolk lecithin 1.2g, glycerin 2.5g, and the rest water for injection, 100ml in total.

[0061] Coenzyme Q 10 The emulsion preparation process is as follows:

[0062] Coenzyme Q 10 Add medium chain oil until completely dissolved, then add purified egg yolk lecithin and shear and stir evenly to obtain an oil phase; dissolve glycerin in water for injection at 40°C to obtain a water phase; add the water phase to the oil phase Stir for 30 minutes to obtain colostrum, adjust the pH value to 5.5-7.0, pass the colostrum through a high-pressure homogenizer, first adjust the pressure of the homogenizer to 5000psi and repeat the homogenization for 3 times, then adjust the pressure of the homogenizer to 15000psi, and repeat the homogenization for 3-3 times Measure the particle size of the emulsion 5 times to obtain a uniformly dispersed emulsion with a particle size of 10...

Embodiment 3

[0064] Coenzyme Q 10 The composition of the emulsion is: Coenzyme Q 10 0.25g, medium chain oil 5g, purified egg yolk lecithin 1.2g, poloxamer188 0.015g, glycerin 2.5g, the rest is water for injection, 100ml in total.

[0065] Coenzyme Q 10 The emulsion preparation process is as follows:

[0066] Coenzyme Q 10 Add medium chain oil until completely dissolved, then add purified egg yolk lecithin and shear and stir evenly to obtain an oil phase; dissolve poloxamer188 and glycerin in water for injection at 60°C to obtain a water phase; add the water phase to the oil Stir in the phase for 30 minutes to obtain colostrum, adjust the pH value to 5.5-7.0, pass the colostrum through a high-pressure homogenizer, first adjust the pressure of the homogenizer to 5000psi and repeat the homogenization for 3 times, then adjust the pressure of the homogenizer to 15000psi, and repeat the homogenization 3 to 5 times, measure the particle size of the emulsion, obtain a uniformly dispersed em...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
The average particle sizeaaaaaaaaaa
Login to view more

Abstract

The present invention discloses one new kind of medicine composition, coenzyme Q10 emulsion, and its preparation process. The emulsion contains coenzyme Q10 as the medicinal component in 0.25 %, and medicinal supplementary material including oil phase 1-20 %, emulsifier 0.01-10 %, auxiliary emulsifier 0.001-5 %, other stabilizer 0-2 % and isoosmotic regulator 1-10 %. Its freeze dried preparation contains also freeze drying protector except water for injection. The present invention also provides freeze dried coenzyme Q10 emulsion and its recipe and preparation process. The coenzyme Q10 emulsion and its freeze dried preparation have high stability even in high temperature up to 40 deg.c and high illumination up to 4500LX+/-500 conditions.

Description

Technical field: [0001] The present invention relates to a kind of coenzyme Q 10 Emulsion and its lyophilized emulsion and preparation method. technical background: [0002] coenzyme Q 10 (Co Q 10 ) has a chemical structure of 2,3-dimethoxy-5-methyl-6-decoprenyl benzoguinone (2,3-dimethoxy-5-methyl-6-decoprenyl benzoguinone), which is a class of Fat-soluble quinones that share characteristics with vitamins. [0003] As early as the 1970s, foreign countries had a great deal of attention to coenzyme Q 10 A large number of clinical application studies have been started, and it has been found that it has excellent curative effects on diseases such as heart disease, malignant tumors, hypertension, cerebrovascular disorders, scurvy, acute hepatitis, etc., and can be used as a non-specific immune enhancer for the body, cell metabolism and Cellular respiration activator. Coenzyme Q 10 The marketed preparations include injections and oral dosage forms such as tablets, capsules...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/122A61K9/107A61K47/44A61P37/04A61P9/00A61P9/12A61P1/16A61P35/00A61K47/24
Inventor 姚瑶陶昱斐
Owner 姚瑶
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap