43results about How to "Novel structure type" patented technology

The invention relates to a flexible microgripper through topological optimization, which belongs to a microactuators in the technical field of the micro electro mechanical systems and is a flexible electrothermally driven microgripper. The flexible microgripper consists of a shift amplifying section and a driving section and is an integral structure with the eudipleural gripper body. The shift amplifying section M is designed by using the topological optimization method and comprises left and right triangular components and a flexible rod, wherein the left and right triangular components randomly hollow triangle structures. The driving section comprises a V-shaped beam array, left and right driving fixed rods and left and right electrodes. The microgripper has the advantages of unique and novel structure, large output shift, rapid response, simple control, convenient integration and is effective and energy-saving without applying drive in the process of gripping objects, thereby the microgripper is quite suitable for gripping minute objects for micro-assembly, micro-operation and the like.

The invention discloses 3-methyl-5,7-diphenyl-5H-thiazolo[3,2-a]pyrimidine-2-carboxamide derivatives shown in a formula I, or pharmaceutically acceptable hydrates or salts of the derivatives, i.e., stereoisomers or tautomers of the derivatives, wherein R1 and R2 in the formula I are respectively hydrogen, methyl, halogen, hydroxyl, methoxyl, acetyl, propionyl, nitro or alkoxy independently; R3 and R4 are independently selected from C1-C6 alkyl, or R3 and R4 form pyrrolyl, piperidinyl, morpholinyl, N-methylpiperazine and N-(4-bromophenyl piperazine) together with nitrogen atoms which are connected with the R3 and the R4. As vascular endothelial growth factor receptor tyrosine kinase inhibitors, the 3-methyl-5,7-diphenyl-5H-thiazolo [3,2-a]pyrimidine-2-carboxamide derivatives can be used for treating and preventing various cancers. The formula I is shown in the description.

The invention discloses a thiazole [3,2-b] [1,2,4]-triazole-6-acetamide derivative as shown in formula I or a pharmaceutically acceptable hydrate and salt thereof. The derivative comprises a stereisomer or tautomer thereof; R1 in the formula I is hydrogen, methyl, halogen, hydroxy, methoxy group, acetyl, propionyl, nitro or alkoxy; R2 and R3 are independently selected from C1-C6 alkyl or R2 and R3 and nitrogen atoms connected with the R2 and R3 are formed into pyrryl, piperidyl, morpholinyl, N-methyl piperazine and N-phenylpiperazine. The thiazole [3,2-b] [1,2,4]-triazole-6-acetamide derivative disclosed by the invention has an obvious restraining function to acetylcholin esterase and is used for enhancing the memory of the patients suffering from dementia and Alzheimer's disease. The invention also relates to a preparation method of the compound and application of the compound for preparing the drug for treating the senile dementia.

The invention discloses a 2-phenyl-6-benzoyl-thiazolo[3,2-b][1,2,4]-triazole derivative disclosed as General Formula I or pharmaceutically acceptable hydrates and salts thereof, including stereomer or tautomers of the 2-phenyl-6-benzoyl-thiazolo[3,2-b][1,2,4]-triazole derivative. In the Formula I, R1 and R2 are respectively and independently hydrogen, methyl group, halogen, hydroxy group, methoxy group, acetyl group, propionyl group, nitro group or alkoxy group. The 2-phenyl-6-benzoyl-thiazolo[3,2-b][1,2,4]-triazole derivative has an obvious inhibiting action on acetylcholinesterase, and is used for enhancing memory of patients with dementia and Alzheimer's disease. The invention also discloses a preparation method of the compounds and application of the compounds in preparing drugs for treating senile dementia.

The invention relates to the field of organic synthesis and medicinal chemistry, in particular to a hederagenin polyethylene glycol derivative with a novel structure and a preparation method of the hederagenin polyethylene glycol derivative. The compound disclosed by the invention is novel in structural type, improved in water solubility and excellent in tumor drug resistance reversion activity. The invention further provides a pharmaceutical composition for treating oral epithelial cancer, gastric cancer, lung cancer, cervical cancer, breast cancer or colon cancer and the like by being combined with clinically common anti-tumor drugs.

The invention belongs to the technical field of medicine, and relates to indole-3-carboxamide compounds and applications thereof. The general structural formula of described indole-3-carboxamide compound is as follows: wherein, R 1 , R 2 , R 3 , R as described in the claims and description. The indole-3-carboxamide compounds of the present invention and the pharmaceutically applicable acid addition salts of such compounds can be used as antioxidants for the preparation of drugs for the treatment or prevention of diseases related to protein oxidative damage, and protein oxidative damage The related diseases caused are Alzheimer's disease, Parkinson's disease, diabetes and chronic renal failure.

The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a helexin polyethylene glycol derivative with a novel structure and a preparation method thereof. The compound of the present invention has a novel structure type, improved water solubility, and excellent tumor drug resistance reversing activity, and further provides a compound used in combination with clinically used antineoplastic drugs for the treatment of oral epithelial cancer, gastric cancer, lung cancer, cervical cancer, breast cancer or colon cancer. Pharmaceutical composition for cancer etc.

The invention discloses the application of helexin polyethylene glycol derivatives. Specifically, the application of the helexin polyethylene glycol derivatives of the present invention in the preparation of tumor drug resistance reversal agents, and the novel structural type helexin polyethylene glycol derivatives provided by the present invention have improved water solubility, have Excellent tumor resistance reversing activity. The helexin polyethylene glycol derivative and a pharmaceutically acceptable carrier are used in combination with clinical antitumor drugs to treat diseases or conditions such as oral epithelial cancer, gastric cancer, lung cancer, cervical cancer, breast cancer or colon cancer. The use of the helexin polyethylene glycol derivative and the medically acceptable salt thereof of the present invention is used for preparing a tumor resistance reversal agent and / or a pharmaceutically acceptable carrier for treating mammals, preferably treating human diseases or diseases.

The invention discloses 2-phenyl-6-benzoyl-thiazolo[3,2-b][1,2,4]-triazole derivatives of general formula I or pharmaceutically acceptable hydrates thereof , salts, including stereoisomers or tautomers thereof, R1 and R2 in formula I are independently hydrogen, methyl, halogen, hydroxyl, methoxy, acetyl, propionyl, nitro or alkane Oxygen. The 2-phenyl-6-benzoyl-thiazolo[3,2-b][1,2,4]-triazole derivatives of the present invention have obvious inhibitory effect on acetylcholinesterase, and are used to enhance Memory in patients with dementia and Alzheimer's disease. The invention also relates to a preparation method of the compound and its application in the preparation of a medicine for treating senile dementia.

The invention discloses 3-methyl-5,7-diphenyl-5H-thiazolo[3,2-a]pyrimidine-2-carboxamide derivatives shown in a formula I, or pharmaceutically acceptable hydrates or salts of the derivatives, i.e., stereoisomers or tautomers of the derivatives, wherein R1 and R2 in the formula I are respectively hydrogen, methyl, halogen, hydroxyl, methoxyl, acetyl, propionyl, nitro or alkoxy independently; R3 and R4 are independently selected from C1-C6 alkyl, or R3 and R4 form pyrrolyl, piperidinyl, morpholinyl, N-methylpiperazine and N-(4-bromophenyl piperazine) together with nitrogen atoms which are connected with the R3 and the R4. As vascular endothelial growth factor receptor tyrosine kinase inhibitors, the 3-methyl-5,7-diphenyl-5H-thiazolo [3,2-a]pyrimidine-2-carboxamide derivatives can be used for treating and preventing various cancers. The formula I is shown in the description.

The invention belongs to the field of medical technology, and relates to a benzoyl substituted thiazolo[3,2-b]-1,2,4-triazine derivative and an application thereof. The benzoyl substituted thiazolo[3,2-b]-1,2,4-triazine derivative comprises a stereoisomer and pharmaceutically acceptable salt of the benzoyl substituted thiazolo[3,2-b]-1,2,4-triazine derivative, wherein the structural general formula is shown in the specification; and the benzoyl substituted thiazolo[3,2-b]-1,2,4-triazine derivative and the pharmaceutically acceptable acid-added salt of the compound can be combined with the existing medicine or independently used as an acetylcholin esterase inhibitor and used for improving the memory of the patients suffering from dementia and Alzheimer disease. Compared with the existing Chinese patent, the 6-site side chain of thiazolo[3,2-b]-1,2,4-triazine is obviously changed, and the inhibition ratio of a sample against acetylcholin esterase is obviously improved.

The invention discloses a thiazole [3,2-b] [1,2,4]-triazole-6-acetamide derivative as shown in formula I or a pharmaceutically acceptable hydrate and salt thereof. The derivative comprises a stereisomer or tautomer thereof; R1 in the formula I is hydrogen, methyl, halogen, hydroxy, methoxy group, acetyl, propionyl, nitro or alkoxy; R2 and R3 are independently selected from C1-C6 alkyl or R2 and R3 and nitrogen atoms connected with the R2 and R3 are formed into pyrryl, piperidyl, morpholinyl, N-methyl piperazine and N-phenylpiperazine. The thiazole [3,2-b] [1,2,4]-triazole-6-acetamide derivative disclosed by the invention has an obvious restraining function to acetylcholin esterase and is used for enhancing the memory of the patients suffering from dementia and Alzheimer's disease. The invention also relates to a preparation method of the compound and application of the compound for preparing the drug for treating the senile dementia.

The invention belongs to the technical field of medicine, and relates to a benzimidazole compound containing a ureido group, a preparation method thereof and an application in preparation of anti-tumor disease medicines. The general structural formula of the described benzimidazole compound containing ureido group, its prodrug and pharmaceutically active metabolite and pharmaceutically acceptable salt is as follows: R can be selected from hydrogen, phenyl, 4-chlorobenzene Base, 4-methylphenyl, 3-(trifluoromethyl)phenyl. R 3 , R 5 Can be selected from hydrogen, methyl. The synthesis method of the compound of the present invention is simple and convenient, and is suitable for industrial production. Biological activity tests show that the compound has antitumor activity, and is a new type of antitumor drug.

The invention belongs to the technical field of medicines, and relates to 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran derivatives and an application thereof. The 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran derivatives comprise stereoisomers and pharmaceutically acceptable salts of 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran, and the structural formula of the derivatives is shownin the description. The 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran derivatives and the pharmaceutically acceptable acid addition formed salts of 5-[2-hydroxy-3-(isopropylamino)propoxy]benzofuran can be used together with existing medicines or individually, and are used for preparing medicines for treating blood vessel smooth muscle spasm diseases.