41results about How to "Novel mechanism" patented technology

A surgical clip applier with scissor-type operating handle and clip applying cartridge in which handle has housing of upper and lower shells that defines socket for receiving cartridge, includes a lever arm actuated linear translator for linear reciprocating movement delivered to the cartridge, and an anti-backup mechanism for full forward and release strokes of the handle, and in which cartridge includes jaws for applying clips, safety means to ensure opening of jaws for each cycle, a puller bar for receiving motion from handle and timing of jaw operation to clip feed, a magazine for feeding clips to jaws in proper sequence, and a lockout mechanism to render applier inoperative after using last clip.

The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.

An automatic safe disposable blood sampling device includes a casing with a launching chamber formed therein. The launching chamber has a lancet needle-exiting hole at a front end thereof; a lancet needle arranged inside the launching chamber; a spring; a launching mechanism composed of the spring and a catch-launching mechanism; a press-launching mechanism provided on the casing; and a self-locking mechanism composed of barbs provided on the press-launching mechanism and self-locking hooks or notches provided on the casing which engage corresponding barbs. When pressed, the press-launching mechanism triggers the catch-launching mechanism, to disengage the lancet needle from the casing. The spring pushes the lancet needle so as to launch the lancet needle. During forward movement of the press-launching mechanism, the barbs pass across the self-locking hooks or notches. In the process of retraction, the barbs are locked with the self-locking hooks or notches and cannot return to their initial states.

An automatic safe disposable blood sampling device includes a casing with a launching chamber formed therein. The launching chamber has a lancet needle-exiting hole at a front end thereof; a lancet needle arranged inside the launching chamber; a spring; a launching mechanism composed of the spring and a catch-launching mechanism; a press-launching mechanism provided on the casing; and a self-locking mechanism composed of barbs provided on the press-launching mechanism and self-locking hooks or notches provided on the casing which engage corresponding barbs. When pressed, the press-launching mechanism triggers the catch-launching mechanism, to disengage the lancet needle from the casing. The spring pushes the lancet needle so as to launch the lancet needle. During forward movement of the press-launching mechanism, the barbs pass across the self-locking hooks or notches. In the process of retraction, the barbs are locked with the self-locking hooks or notches and cannot return to their initial states.

The invention relates to monitoring of pain-related responses in a patient in order to detect the level of pain experienced by the patient. At least one first measurement signal is acquired from the patient and at least one of the signals is transformed into a normalized signal having a predetermined value range. Based on the at least one normalized signal obtained in this way, a threshold condition is set and a rate at which at least one second measurement signal fulfills the threshold condition is monitored, wherein each of the at least one second measurement signal is derivable from a corresponding normalized signal and indicative of pain-related activity in the patient. The level of pain experienced by the patient depends on the rate monitored.

A clip applier of handle and cartridge for applying clips in surgical procedures with handle preferably a scissors type defined by a housing of shell members containing a cam operated linear translator actuated by handle levers, an anti-backup mechanism limiting handle lever movement to full pull and release strokes while preventing partial pull or release handle strokes, and with cartridge fitted with lockout mechanism to disable applier after last clip is used in surgery, with a puller bar lock to hold puller bar position in cartridge prior to assembly with handle, a detent spring mounted in cartridge cover member as part of clip handling mechanism, and a rapid-fire pawl as part of clip handling mechanism to prevent cartridge jamming when clips are applied in rapid succession.

In this application, the invention is a novel heuristic mechanism of working path and backup path reservation for highly utilizable WDM mesh networks, which we call dynamic-network adapted cost selection (DAC-selection) mechanism. One of its characteristics is simple traffic distribution mechanism, and the performance of DAC-selection mechanism is superior to that of Random selection (R-selection) and Advanced Combined Min-cost selection (ACM-selection) mechanism. DAC-selection mechanism provides simple cost function by assigning proper weights to each component of the cost function and the total cost is obtained by just summing up the individual cost. Therefore, it is possible to select a best pair of working path and backup path which consumes least wavelength for reservation.

The invention relates to the determination of the clinical stress of a subject. In order to bring about an uncomplicated and cost-effective method for monitoring the stress status of a subject, plethysmographic signal data is acquired from the subject and a first measurement signal is derived, which is indicative of a predetemined feature of the respiration modulation appearing in the said signal data. An index signal is then formed based on the first measurement signal and the index signal is employed as an index indicative of the clinical stress of the subject.

In order to provide a non-invasive and continuous concentration measurement with the technology of standard pulse oximeters, an a priori relationship is created, through an in-vivo tissue model including a nominal estimate of a tissue parameter indicative of the concentration of a blood substance. The a priori relationship is indicative of the effect of tissue on in-vivo measurement signals at a plurality of wavelengths, the in-vivo measurement signals being indicative of absorption caused by pulsed arterial blood. In-vivo measurement signals are acquired from in-vivo tissue at the plurality of wavelengths and a specific value of the tissue parameter is determined based on the a priori relationship, the specific value being such that it yields the effect of the in-vivo tissue on the in-vivo measurement signals consistent for the plurality of wavelengths. The specific value then represents the concentration of the substance in the blood.

A system for independent component analysis includes a feedback mechanism based on a plasticity rule, and an electro-kinetic induced particle chain, wherein the feedback mechanism and the electro-kinetic induced particle chain is utilized to extract independent components from a data set or data stream. The electro-kinetic induced particle chain is generally composed of a plurality of interconnected nanoconnections (e.g., nanoparticles) disposed between at least two electrodes in a solution, including for example one or more pre-synaptic electrodes and one or more post-synaptic electrodes. The feedback mechanism generally provides feedback to one or more particles within the electro-kinetic induced particle chain, while the plasticity rule can be non-linear in nature. The feedback mechanism also provides for one or more evaluate phases and one or more feedback phases.

A clip applier of handle and cartridge for applying clips in surgical procedures with handle preferably a scissors type defined by a housing of shell members containing a cam operated linear translator actuated by handle levers, an anti-backup mechanism limiting handle lever movement to full pull and release strokes while preventing partial pull or release handle strokes, and with cartridge fitted with lockout mechanism to disable applier after last clip is used in surgery, with a puller bar lock to hold puller bar position in cartridge prior to assembly with handle, a detent spring mounted in cartridge cover member as part of clip handling mechanism, and a rapid-fire pawl as part of clip handling mechanism to prevent cartridge jamming when clips are applied in rapid succession.

Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin / TGF-b•type II•type I complex, thereby blocking the signaling of activin and TGF-b. Cripto may be generally capable of blocking antiproliferative Smad2 / 3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin / TGF-b complex may enhance antiproliferative effects of activin and TGF-b.

A surgical clip applier with scissor-type operating handle and clip applying cartridge in which handle has housing of upper and lower shells that defines socket for receiving cartridge, includes a lever arm actuated linear translator for linear reciprocating movement delivered to the cartridge, and an anti-backup mechanism for full forward and release strokes of the handle, and in which cartridge includes jaws for applying clips, safety means to ensure opening of jaws for each cycle, a puller bar for receiving motion from handle and timing of jaw operation to clip feed, a magazine for feeding clips to jaws in proper sequence, and a lockout mechanism to render applier inoperative after using last clip.

The invention provides GA / Fe2+ nanoparticles, composite nanoparticles thereof, preparation and application. The GA / Fe2+ nanoparticles comprise or are obtained by compounding the following raw materials: Fe2+ salt, PVP and GA. ZIF-8 is adopted to encapsulate the GA / Fe2+ nanoparticles and carry drugs such as DOX and / or GOX to obtain the composite nanoparticles, the content of iron ions in tumor cells can be remarkably increased, meanwhile, in combination with the carried drugs, a synergistic effect on tumor killing is achieved, a Fenton reaction is promoted, tumor cell iron death is induced, andtherefore, growth of the tumor cells is effectively inhibited.

Embodiments of the present invention generally relate to a vehicle-mounted conveyor system, and more specifically a maneuverable and mobile system interconnected to a motor vehicle, such as a truck, for conveying products and material. In some embodiments, the conveyor system comprises: a first conveyor; a second conveyor; a conveyor mount, wherein the first conveyor is interconnected to the conveyor mount; a first plate; a second plate; a post interconnected to the first plate; an arm member interconnected on one end to the post and interconnected on a second end to the second plate; a first hydraulic cylinder interconnected to the post and the arm member; a rotator gear interconnected to the second plate and the conveyor mount; a second hydraulic cylinder interconnected to the conveyor mount and the rotator gear; and a vehicle stabilizer, wherein the conveyor system has a first travel position and a second deployed position.

Embodiments of the present invention generally relate to a vehicle-mounted conveyor system, and more specifically a maneuverable and mobile system interconnected to a motor vehicle, such as a truck, for conveying products and material. In some embodiments, the conveyor system comprises: a first conveyor; a second conveyor; a conveyor mount, wherein the first conveyor is interconnected to the conveyor mount; a first plate; a second plate; a post interconnected to the first plate; an arm member interconnected on one end to the post and interconnected on a second end to the second plate; a first hydraulic cylinder interconnected to the post and the arm member; a rotator gear interconnected to the second plate and the conveyor mount; a second hydraulic cylinder interconnected to the conveyor mount and the rotator gear; and a vehicle stabilizer, wherein the conveyor system has a first travel position and a second deployed position.

A disconnecting mechanism includes a main body including a fluid transfer tip having a tapered surface to form a friction fit with a corresponding connector. The lever member includes a threaded portion to enable the corresponding connector part to be connected to the fluid transfer tip by a screw fit in addition to the friction fit, and an actuator portion to actuate release of the friction fit. In a first pivotal position, the threaded portion has a first position close to the fluid transfer tip to engage with an outer thread or rim of the corresponding part and thereby form the screw fit in addition to the friction fit. In a second pivotal position, the threaded portion has a second position further away from the fluid transfer tip to disconnect the screw fit and the actuator portion is moved forward to push the connector part and release the friction fit.

The invention belongs to the technical field of medicines, in particular to Pt+si-GPX4(at)IONPs and FA / Pt+si-GPX4(at)IONPs nano-particles as well as a preparation method and an application thereof. According to the invention, three therapeutic drugs, i.e., cis-platinum, si-GPX4 and IONPs, are combined into a whole; glioma cell death is jointly induced from two aspects of cell apoptosis and ferroptosis; in addition, the FA-modified liposome is used for wrapping three medicines, namely cis-platinum, si-GPX4 and IONPs, the advantages of good targeting property and high biocompatibility are achieved, a very good treatment effect on glioma is achieved, the defects of a traditional single chemotherapy medicine are overcome, and a multi-target combined chemotherapy method for glioma cells is provided.

The invention discloses a negative Poisson's ratio structure based on a rotating rod unit. The structure comprises a plurality of rotating rod units, wherein the plurality of rotating rod units are periodically arranged and combined in a plane; each rotating rod unit comprises two flexible curved beam units, four bent rods and two straight rods, wherein the two flexible curved beam units are connected between the two straight rods and are symmetrically distributed, the four bent rods are connected to the two flexible curved beam units and are symmetrically distributed, the rotating rod units which are adjacent left and right are directly connected through symmetrical bent rod end parts, and the rotating rod units which are adjacent up and down are directly connected through symmetrical straight rod end parts. The negative Poisson's ratio structure based on the rotating rod unit is simple and effective and good in manufacturability, and has the advantages of being small in stress concentration force and facilitating energy storage and conversion.

The present invention belongs to the field of genetic treating medicine of tumor, and is antitumor genetic transcription regulatory medicine. The medicine component consists of 15-40 nucleotides, contains decoy nucleic acid with specific sequence 5í»-SCCNNNVSS-3í», may be combined specifically with transcription factor AP-2 via competition with several genes containing cis element with the factor combining site, and can regulate gene expression and suppress malignant amplification of tumor to treat tumors.

In order to provide a non-invasive and continuous concentration measurement with the technology of standard pulse oximeters, an a priori relationship is created, through an in-vivo tissue model including a nominal estimate of a tissue parameter indicative of the concentration of a blood substance. The a priori relationship is indicative of the effect of tissue on in-vivo measurement signals at a plurality of wavelengths, the in-vivo measurement signals being indicative of absorption caused by pulsed arterial blood. In-vivo measurement signals are acquired from in-vivo tissue at the plurality of wavelengths and a specific value of the tissue parameter is determined based on the a priori relationship, the specific value being such that it yields the effect of the in-vivo tissue on the in-vivo measurement signals consistent for the plurality of wavelengths. The specific value then represents the concentration of the substance in the blood.

A fluid transfer device or connection with a fluid transfer tip that has a tapered friction fitting for a corresponding hub. A lever member is pivotally mounted to move relative to the fluid transfer tip. A latch such as a screw thread is mounted on the lever member to engage the hub and provide a positive connection e.g., screw fit in addition to the friction fitting. The lever member may optionally be resiliently biased by a spring. The hub is disconnected from the tip by pivoting the lever member to release the positive connection with the hub and to subsequently release the hub from the friction fitting.

Embodiments of the present invention generally relate to a vehicle-mounted conveyor system, and more specifically a maneuverable and mobile system interconnected to a motor vehicle, such as a truck, for conveying products and material. In some embodiments, the conveyor system comprises: a first conveyor; a second conveyor; a conveyor mount, wherein the first conveyor is interconnected to the conveyor mount; a first plate; a second plate; a post interconnected to the first plate; an arm member interconnected on one end to the post and interconnected on a second end to the second plate; a first hydraulic cylinder interconnected to the post and the arm member; a rotator gear interconnected to the second plate and the conveyor mount; a second hydraulic cylinder interconnected to the conveyor mount and the rotator gear; and a vehicle stabilizer, wherein the conveyor system has a first travel position and a second deployed position.

A disconnecting mechanism includes a main body including a fluid transfer tip having a tapered surface to form a friction fit with a corresponding connector. The lever member includes a threaded portion to enable the corresponding connector part to be connected to the fluid transfer tip by a screw fit in addition to the friction fit, and an actuator portion to actuate release of the friction fit. In a first pivotal position, the threaded portion has a first position close to the fluid transfer tip to engage with an outer thread or rim of the corresponding part and thereby form the screw fit in addition to the friction fit. In a second pivotal position, the threaded portion has a second position further away from the fluid transfer tip to disconnect the screw fit and the actuator portion is moved forward to push the connector part and release the friction fit.

The invention provides a chitosan oligosaccharide composition. The chitosan oligosaccharide composition mainly comprises chitosan oligosaccharide, an antioxidant, an osmotic pressure regulator, a pH regulator and the like, wherein the chitosan oligosaccharide is composed of chitosan oligosaccharide 1000 (COST) and chitosan oligosaccharide 3000 (COSM). The composition is in the form of an injection, the preparation process is simple and convenient, and industrial production is facilitated. The chitosan oligosaccharide composition provided by the invention can significantly reduce the increase of ALT and AST when acetaminophen induces liver injury, and can reduce MDA and increase GSH content, indicating that COST and COSM can reduce oxidative injury; in addition, the content of liver antioxidant enzyme, including SOD, GSH-Px and CAT, can be significantly increased, indicating that the oxidation resistance of the liver can be improved.

The invention belongs to the technical field of bio-pharmaceuticals, and provides application of a benzimidazole compound serving as an immunosuppressor in preparation of medicines for treating autoimmune diseases in the presence of T cells, such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus and autoimmunenephritis. A series of novel compounds synthesized by the benzimidazole compound have the advantages of being remarkable in efficacy, novel in mechanism, effective in oral taking, and less in toxic and side effects; and compared with a conventional medicine, the benzimidazole compound is remarkably advantaged in simple synthesis route and environment-friendly.

The invention belongs to the technical field of bio-pharmaceuticals, and provides application of a benzimidazole compound serving as an immunosuppressor in preparation of medicines for treating autoimmune diseases in the presence of T cells, such as inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus and autoimmunenephritis. A series of novel compounds synthesized by the benzimidazole compound have the advantages of being remarkable in efficacy, novel in mechanism, effective in oral taking, and less in toxic and side effects; and compared with a conventional medicine, the benzimidazole compound is remarkably advantaged in simple synthesis route and environment-friendly.