The invention provides an insecticide composition with chlorpyrifos-methyl. The insecticide composition comprises the chlorpyrifos-methyl and neonicotinoid insecticides. The neonicotinoid insecticides are selectively a type or a plurality of types of thiamethoxam, dinotefuran, acetamiprid, thiacloprid, clothianidin, imidaclothiz, IPP, cycloxaprid and flupyradifurone; a mass ratio of the chlorpyrifos-methyl to the neonicotinoid insecticides is 1:50-50:1, preferably is 1:10-10:1 and optimally is 1:4-4:1. The insecticide composition with the chlorpyrifos-methyl has the advantage that the insecticide composition can be used for preventing and treating injurious insects on rice, wheat, corn, soybeans, cotton, tomatoes, cucumbers, cabbages, broccoli, chili, potatoes, cow peas, kidney bean, citruses, peaches, apples, pears or tea trees.