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41 results about "Convection-Enhanced Delivery" patented technology
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Convection Enhanced Delivery (CED) is a therapeutic strategy that was developed to facilitate targeted delivery of pharmaceuticals to the brain. The CED procedure involves a minimally invasive surgical exposure of the brain, followed by placement of small diameter catheters directly into the brain tumor.
Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
ActiveUS20070088295A1Increase flow rateOvercome limitationsGuide needlesCannulasRefluxTherapeutic effect
A step-design cannula and delivery system for chronic delivery of therapeutic substances into the brain using convention-enhanced delivery of therapeutic substances and which effectively prevents reflux in vivo and maximizes distribution in the brain.
Owner:RGT UNIV OF CALIFORNIA
Method for convection enhanced delivery catheter to treat brain and other tumors
InactiveUS6974448B2Less traumaticIncreased surgical riskPharmaceutical delivery mechanismMedical devicesAbnormal tissue growthBiological body
A method is provided for delivering a therapeutic agent to selected sites within an organism. More particularly, the invention allows for the simultaneous delivery of therapeutics to multiple treatment locations from a single catheter using a single pumping source. The catheter utilizes a microporous membrane that allows for the distribution of therapeutic agents from multiple longitudinal positions.
Owner:MEDTRONIC INC
Convection-enhanced delivery of AAV vectors
InactiveUS20020141980A1Efficient deliveryEfficient expressionBiocideOrganic active ingredientsDiseaseConvection-Enhanced Delivery
Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
Owner:GENZYME CORP
Convection enhanced delivery catheter to treat brain and other tumors
InactiveUS6893429B2Less traumaticIncreased surgical riskPressure infusionCatheterBiological bodyAbnormal tissue growth
An apparatus and system is provided for delivering a therapeutic agent to selected sites within an organism. More particularly, the invention allows for the simultaneous delivery of therapeutics to multiple treatment locations from a single catheter using a single pumping source. The catheter utilizes a microporous membrane that allows for the distribution of therapeutic agents from multiple longitudinal positions.
Owner:MEDTRONIC INC
Method for convection enhanced delivery of therapeutic agents
ActiveUS20060073101A1Improve securityFast imagingNervous disorderMagnetic measurementsTherapeutic effectConvection-Enhanced Delivery
A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and / or by X-ray computed tomography (CT) is co-infulsed with the therapeutic agent and used to monitor the distribution of the therapeutic agent as it moves through the target tissue. The images obtained during delivery are used to confirm delivery of the therapeutic agent to the target tissue and to avoid exposure of tissue outside of the targeted area to the therapeutic agent. In addition, the signal intensity of the images may be used to confirm that the therapeutic agent has been delivered to the target tissue at a desired concentration.
Owner:US DEPT OF HEALTH & HUMAN SERVICES
Ultrasound-assisted convection enhanced delivery of compounds in vivo with a transducer cannula assembly
ActiveUS20130046230A1Reduce decreaseUltrasonic/sonic/infrasonic diagnosticsPiezoelectric/electrostrictive device manufacture/assemblyUltrasonic sensorDistribution Volume
A method for convection-enhanced delivery (CED) of compounds and an apparatus for use with the method are provided. The apparatus, an ultrasound transducer cannula assembly (TCA) apparatus, can be used for the delivery of a compound to a target in the body such as a cells, tissue or organ in a healthy or diseased state. The ultrasound TCA apparatus comprises a transducer cannula assembly (TCA) and an ultrasound system to enhance penetration of molecules in the target. The ultrasound system may be portable and pocket-sized. The inclusion of ultrasound in the apparatus improves the distribution volume of material four to six times over a convection-enhanced delivery system without ultrasound. Since the targeting can be more focused, less compound is needed, thus lowering the potential for harmful effects to the host and host cells.
Owner:CORNELL UNIVERSITY
Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
A step-design cannula and delivery system for chronic delivery of therapeutic substances into the brain using convention-enhanced delivery of therapeutic substances and which effectively prevents reflux in vivo and maximizes distribution in the brain.
Owner:RGT UNIV OF CALIFORNIA
Highly Penetrative Nanocarriers for Treatment of CNS Disease
ActiveUS20150118311A1Improve survivalTreatment of brain tumorsBiocidePowder deliveryDrugs solutionNanocarriers
Brain-penetrating polymeric nanoparticles that can be loaded with drugs and are optimized for intracranial convection-enhanced delivery (CED) have been developed. In the preferred embodiment, these are loaded with FDA-approved compounds, identified through library screening to target brain cancer stem cells (BSCSs). The particles are formed by emulsifying a polymer-drug solution, then removing solvent and centrifuging at a first force to remove the larger particles, then collecting the smaller particles using a second higher force to sediment the smaller particles having a diameter of less than 100 nm, more preferably less than 90 nanometers average diameter, able to penetrate brain interstitial spaces.
Owner:YALE UNIV
Method for convection enhanced delivery of therapeutic agents
ActiveUS7371225B2Accurately rapidly imagingAccurately correlatedNervous disorderMagnetic measurementsTherapeutic effectConvection-Enhanced Delivery
A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and / or by X-ray computed tomography (CT) is co-infused with the therapeutic agent and used to monitor the distribution of the therapeutic agent as it moves through the target tissue. The images obtained during delivery are used to confirm delivery of the therapeutic agent to the target tissue and to avoid exposure of tissue outside of the targeted area to the therapeutic agent. In addition, the signal intensity of the images may be used to confirm that the therapeutic agent has been delivered to the target tissue at a desired concentration.
Owner:UNITED STATES OF AMERICA
Selective treatment of IL-13 expressing tumors
A method of treating tumors that express a receptor for IL-13 is disclosed. The method involves directly introducing into the tumor a cytotoxin that targets the IL-13 receptor. The cytotoxic agent can be introduced by convection-enhanced delivery through a suitable catheter or by other means. Where a convection-enhanced catheter is employed, the method involves positioning the tip of a catheter at least in close proximity to the tumor. After the catheter is positioned, it is connected to a pump which delivers the active agent through the catheter tip to the tumor. A pressure gradient from the tip of the catheter is maintained during infusion.
Owner:DEPT OF HUMAN SERVICES UNITED OF AMERICA AS REPRESENTED BY THE SEC OF THE
Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
InactiveUS20070259031A1Improved tissue distributionLow toxicityOrganic active ingredientsNervous disorderTherapeutic treatmentConvection-Enhanced Delivery
Owner:RGT UNIV OF CALIFORNIA
Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique
InactiveUS7963956B2Efficient deliveryImprove bioavailabilityMedical devicesPharmaceutical delivery mechanismEngineeringConvection-Enhanced Delivery
The present invention is directed to a device for a portable convection enhanced delivery system that allows administering liquids to specific locations within the body, especially tissues and tumors also allowing outsubject treatment. The application system comprises a portable extracorporal pump with a fluid reservoir that is connected via an infusion system to an infusion catheter placeable to any tissue or tumor the fluid should be administered to by high flow microperfusion. The system enables administration of fluids of any kind by convection enhanced delivery also in out-patient treatment. The system can be used for delivering various drugs, proteins, protein toxins, antibodies-for treatment or imaging, proteins in enzyme replacement therapy, growth factors and viruses or oligonucleotides in gene therapy etc. The application methods as well as the surgical method to implant this device are enclosed to this invention.
Owner:ANTISENSE PHARMA GMBH
Optimized intracranial catheters for convection-enhanced delivery of therapeutics
ActiveUS20120041394A1Rigid enoughReduce the overall diameterSurgical needlesCatheterConvection-Enhanced DeliveryIntracranial catheter
A primable catheter including a thermoreactive, viscoelastic material that is internally supported with a trocar wire. The primable catheter further includes a multi-chamfered tip and a gap interposed between an inner surface of the catheter and the outer surface of the trocar, such that a priming fluid is permitted to flow through the catheter and purge air trapped between the trocar and the inner surface of the catheter. Following insertion of the catheter, the trocar is removed and a therapeutic is infused via the catheter.
Owner:BECTON DICKINSON & CO
Liposomal Composition for Convection-Enhanced Delivery to the Central Nervous Centre
ActiveUS20110274625A1Improved tissue distributionConvection-enhanced delivery (CED)BiocideNervous disorderPhospholipidDrug release
Convection-enhanced delivery (CED) is used as a method to deliver a direct infusion of therapeutic agents to the central nervous centre thus circumventing the blood-blood barrier. A non-PEGylated liposomal composition comprising at least one saturated neutral phospholipid and at least one saturated anionic phospholipid and a therapeutic or diagnostic agent encapsulated therein is used to overcome toxicity associated with high peak drug concentration delivered locally CED as well as to increase tissue distribution volume for an improved sustained drug release. In one embodiment, the liposome composition comprises a molar ratio of DSPC:DSPG:CHOL of 7:2:1 and the therapeutic or diagnostic agent is selected from topotecan, conotoxin, gadodiamide or rhodamine, and is used in the treatment of epilepsy
Owner:MEDGENESIS THERAPEUTIX INC
Convection enhanced delivery apparatus, method, and application
ActiveUS8790317B2Reduce the cross-sectional areaIncrease chancePowder deliveryPeptide/protein ingredientsParyleneConvection-Enhanced Delivery
An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and / or a pump and / or a meter and / or a valve or other suitable control device(s) or apparatus that supplies and / or delivers fluid (eg, a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device.
Owner:CORNELL UNIVERSITY +1
Adjustable stepped cannula
The use of stepped cannulas, wherein a step structure creates a backstop to reduce backflow along the cannula body, is known for convection enhanced delivery of agents to the brain and other structures within an animal. Described herein are novel and improved stepped cannula designs wherein the length of the cannula segment between the step and the dispensing outlet is variable and can be controllably adjusted inside the patient during delivery. This advantageously allows the operator to place the cannula step at the optimal position and deliver agents at one or more positions within the target structure.
Owner:RGT UNIV OF CALIFORNIA
Methods for Distributing High Levels of Therapeutic Agent Throughout the Cortex to Treat Neurological Disorders
ActiveUS20120027726A1Unprecedented volumeExpand the scope ofBiocideNervous disorderDiseaseNervous system
The invention provides methods for treating neurological disorders, which involve administering therapeutic agents to the thalamus by convection enhanced delivery.
Owner:RGT UNIV OF CALIFORNIA
Drug supply system for CED (convection-enhanced delivery) catheter infusions
ActiveUS7972305B2Fast reconnectionMedical devicesIntravenous devicesConvection-Enhanced DeliveryDrug supply
A drug supply system for CED (convection-enhanced delivery) catheter infusions is provided, the system including a drug conducting system having a drug depot and a catheter supply line and a conveying device that provides for conveying the drug from the drug depot into the catheter supply line. The drug conducting system is a system that is closed to the outside in a fluidic seal The drug supply system further includes a conveying fluid conveying system arranged between the conveying device and the drug supply system and is connected to the conveying device and to the drug depot, via a drug displacement element, without fluid-drug contact.
Owner:BRAINLAB
Metronomic Convection Enhanced Delivery of Intrathecal Chemotherapy Using an Implanted Magnetic Breather Pump (MBP) for Leptomeningeal Carcinomatosis
A magnetically controlled pump is implanted into the cerebrospinal fluid of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled lumen, intratumoral catheter which will be implanted. Spinal fluid drawn from the patient is analyzed. Medication is delivered on a continuous metronomic basis into the CSF via an internalized pump. CSF is removed and analyzed for VEGF and other cytokines via spectrophotometer analysis or a lab on a chip. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
Owner:COGNOS THERAPEUTICS INC
Glioma treatment
InactiveUS20160136284A1BiocideInorganic active ingredientsConvection-Enhanced DeliveryArtificial cerebrospinal fluid
A method of treating a glioma is disclosed. The method includes administering to a patient in need thereof a composition that includes a chemotherapy agent and artificial cerebrospinal fluid via convection enhanced delivery.
Owner:RENISHAW PLC
Systems and methods for providing a convection-enhanced delivery device
ActiveUS9278193B2Reduce distanceReduced vertical profileCatheterInfusion needlesInsertion depthConvection-Enhanced Delivery
A delivery device system is provided for assisting a patient and physician in maintaining a depth and position of an inserted catheter within a target tissue. The delivery device includes a base member that is secured to an external surface of the patient. The base member includes an aperture through which a catheter is inserted to access the target tissue. The base member further includes a hinged clip that selectively locks into a closed position to secure the catheter within the delivery device and maintain a desired insertion depth of the catheter within the target tissue. The base member further includes a receiving channel for compatibly and adjustably securing an adapter portion of the catheter in a horizontal orientation.
Owner:BECTON DICKINSON & CO
Tissue infusion system and method
InactiveUS20140148782A1Reduce deliveryEasy to operateGuide needlesInfusion syringesFiberHollow fibre
An apparatus and corresponding method for providing convection enhanced delivery of bioactive agent to a tissue site. The apparatus involves the use of semipermeable membranes, typically in the form of one or more hollow fibers, together with a source and conduit of solution containing the bioactive agent to be delivered. The use of hollow fiber technology provides an optimal combination of features, including delivery kinetics and distribution, as compared to conventional (e.g., standard needle) type delivery devices.
Owner:TWIN STAR MEDICAL
Compositions and Methods for Convection Enhanced Delivery of High Molecular Weight Neurotherapeutics
InactiveUS20100098639A1Reduce deliveryImproved tissue distributionBiocideNervous disorderMedicineTherapeutic treatment
Owner:RGT UNIV OF CALIFORNIA
Glioma treatment
InactiveUS20150037437A1Heavy metal active ingredientsBiocideConvection-Enhanced DeliveryArtificial cerebrospinal fluid
A chemotherapy agent or a pharmaceutical composition including chemotherapy agent and artificial cerebrospinal fluid, wherein the chemotherapy agent at a concentration of between 0.01 mg / ml and 0.7 mg / ml for use in the treatment of brain cancer and a method of treating a glioma including administering a chemotherapy agent via convection enhanced delivery
Owner:RENISHAW PLC
Treating Tumors of the Central Nervous System
A synergistic therapeutic effect is obtained in CNS cancer patients treated concomitantly with a first antineoplastic agent and a second antineoplastic agent, wherein one or both antineoplastic agents are administered by convection enhanced delivery. Combinations of interest include, without limitation, CED delivery of a topoisomerase inhibitor, e.g., topotecan, and systemic delivery of a triazene, e.g. temozolomide.
Owner:RGT UNIV OF CALIFORNIA
Delivery of a gene therapy vector to the brain by convection-enhanced delivery
ActiveUS8901077B2Raise the ratioEasy to movePeptide/protein ingredientsSerum albuminConvection-Enhanced DeliveryAlbumin
Owner:RENISHAW (IRELAND) LTD +1
Ultrasound-assisted convection enhanced delivery of compounds in vivo with a transducer cannula assembly
ActiveUS10537725B2Reduce decreaseUltrasonic/sonic/infrasonic diagnosticsPiezoelectric/electrostrictive device manufacture/assemblyConvection-Enhanced DeliveryIn vivo
A method for convection-enhanced delivery (CED) of compounds and an apparatus for use with the method are provided. The apparatus, an ultrasound transducer cannula assembly (TCA) apparatus, can be used for the delivery of a compound to a target in the body such as a cells, tissue or organ in a healthy or diseased state. The ultrasound TCA apparatus comprises a transducer cannula assembly (TCA) and an ultrasound system to enhance penetration of molecules in the target. The ultrasound system may be portable and pocket-sized. The inclusion of ultrasound in the apparatus improves the distribution volume of material four to six times over a convection-enhanced delivery system without ultrasound. Since the targeting can be more focused, less compound is needed, thus lowering the potential for harmful effects to the host and host cells.
Owner:CORNELL UNIVERSITY
Delivery of a therapeutic agent to the cerebral cortex by administering a viral vector by convection enhanced diffusion into the white matter of the brain
ActiveUS20160143966A1Reduce the possibilityBiocidePharmaceutical delivery mechanismSpinal cordCatheter
Methods for delivering a therapeutic agent to a cerebral cortex or to the cerebral cortex and spinal cord include administering a viral vector that includes the therapeutic agent into white matter of a brain in order to deliver the therapeutic agent to the cerebral cortex or to the cerebral cortex and spinal cord. Kits for performing such methods may include at least one viral vector, at least one therapeutic agent, and a convection enhanced delivery (CED) catheter.
Owner:NEUROCHASE INNOVATIONS LTD
Delivery of a therapeutic agent to the cerebral cortex by administering a viral vector by convection enhanced diffusion into the white matter of the brain
Owner:NEUROCHASE INNOVATIONS LTD
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