The invention discloses a multi-degree-of-freedom single-wound-hole robot flexible hand for celiac minimally invasive surgery, which comprises two seven-degree-of-freedom mechanical arms and a five-degree-of-freedom mechanical arm. Tail ends of the seven-degree-of-freedom mechanical arms are provided with scalpels, the tail end of the five-degree-of-freedom mechanical arm is provided with a cameral, seven degrees of freedom of each seven-degree-of-freedom mechanical arm include the rotation degree of freedom around a center shaft of the arm, the arm front and back stretching and retracting degree of freedom, the horizontal swinging degree of freedom, the vertical swinging degree of freedom, the horizontal swinging degree of freedom, the vertical swinging degree of freedom and the tool degree of freedom which are successively arranged from the root of the seven-degree-of-freedom mechanical arm, the front and back stretching and retracting degree of freedom and the rotation degree of freedom around a center line of the arm are arranged at the tail end, which contacts with a mouth gag, of the five-degree-of-freedom mechanical arm, three planar swinging degrees of freedom deeply penetrate into the mouth gag and are successively arranged from the root of the five-degree-of-freedom mechanical arm, and transmission of each degree of freedom is controlled via a steel wire. The multi-degree-of-freedom single-wound-hole robot flexible hand is a single-hole operation multi-degree-of-freedom mechanism, and can realize surgical operations including incising, pulling, suturing and the like, so that operability and accuracy of the surgery are improved.