30 results about "Atrial tissue" patented technology

A method and apparatus for treating a body tissue in situ (e.g., an atrial tissue of a heart to treat) atrial fibrillation include a lesion formation tool is positioned against the heart surface. The lesion formation tool includes a guide member having a tissue-opposing surface for placement against a heart surface. An ablation member is coupled to the guide member to move in a longitudinal path relative to the guide member. The ablation member has an ablation element for directing ablation energy in an emitting direction away from the tissue-opposing surface. The guide member may be flexible to adjust a shape of the guide member for the longitudinal path to approximate the desired ablation path while maintaining the tissue-opposing surface against the heart surface. In one embodiment, the ablation member includes at least one radiation-emitting member disposed to travel in the longitudinal pathway. Transmurality can be assessed to approximate a location of non-transmurality in a formed lesion.

A method and apparatus for treating a body tissue in situ (e.g., an atrial tissue of a heart to treat atrial fibrillation) include a lesion formation tool is positioned against the heart surface. The apparatus includes a guide member having a tissue-opposing surface for placement against a heart surface. The guide member also has interior surfaces and a longitudinal axis. A guide carriage is sized to be received with the guide member and moveable therein along the longitudinal axis. An optical fiber is positioned within the guide carriage with the carriage retaining the fiber. The carriage receives the fiber with an axis substantially parallel to the longitudinal axis and bends the fiber to a distal tip with an axis of said fiber at said distal tip at least 45 degrees to the longitudinal axis and aligned for discharge of laser energy through the tissue opposing surface.

An embodiment of the invention includes a surgical device for coagulating soft tissue such as atrial tissue in the treatment of atrial fibrillation, atrial flutter, and atrial tachycardia; tendon or ligament shrinkage; or articular cartilage removal. The surgical device integrates a suction mechanism with the coagulation mechanism improving the lesion creation capabilities of the device. The surgical device comprises an elongate member having an insulative covering attached about conductive elements capable of coagulating soft tissue when radiofrequency or direct current energy is transmitted to the conductive elements. Openings through the insulative covering expose regions of the conductive elements and are coupled to lumens in the elongate member which are routed to a vacuum source. Suction causes the soft tissue to actively engage the opening thus the integrated, exposed conductive elements to facilitate the coagulation process and ensure the lesions created are consistent, continuous, and transmural. The embodiments of the invention can also incorporate cooling mechanisms associated with the conductive elements and coupled to a fluid source to passively transport fluid along the contacted soft tissue surface to cool thus pushing the maximum temperature deeper into tissue.

An embodiment of the invention includes a surgical device for coagulating soft tissue such as atrial tissue in the treatment of atrial fibrillation, atrial flutter, and atrial tachycardia; tendon or ligament shrinkage; or articular cartilage removal. The surgical device integrates a suction mechanism with the coagulation mechanism improving the lesion creation capabilities of the device. The surgical device comprises an elongate member having an insulative covering attached about conductive elements capable of coagulating soft tissue when radiofrequency or direct current energy is transmitted to the conductive elements. Openings through the insulative covering expose regions of the conductive elements and are coupled to lumens in the elongate member which are routed to a vacuum source. Suction causes the soft tissue to actively engage the opening thus the integrated, exposed conductive elements to facilitate the coagulation process and ensure the lesions created are consistent, continuous, and transmural. The embodiments of the invention can also incorporate cooling mechanisms associated with the conductive elements and coupled to a fluid source to passively transport fluid along the contacted soft tissue surface to cool thus pushing the maximum temperature deeper into tissue.

Featured is a catheter device for ablating tissue that includes an elongated body member having a distal portion and a deflection mechanism operably coupled to the distal portion so as to cause the distal portion to deflect with respect to a longitudinal axis of the elongated body member. Such a catheter device also includes a guide member and a guiding mechanism that is coupled to the elongated body member and is configured so as to guide the guide member. The guiding mechanism includes an exit portion from which the guide member exits during deployment. The exit portion is disposed with respect to the distal portion end so the distal portion deflects from and with respect to the guide member as well as rotating about the guide member. Also featured are systems and methods related thereto.

A method for ablation in which a portion of atrial tissue around the pulmonary veins of the heart is ablated by a first elongated ablation component and a second elongated ablation component movable relative to the first ablation component and having means for magnetically attracting the first and second components toward one another. The magnetic means draw the first and second components toward one another to compress the atrial tissue therebetween, along the length of the first and second components and thereby position the device for ablation of the tissue.

Methods and devices are disclosed herein for therapeutically treating atrial tissue to lessen the effects of mechanical stress on atrial tissue, where reducing mechanical stress in the portion of atrial tissue reduces formation of at least one arrhythmia substrate. In one example, the devices and methods are suitable for minimally invasive surgery. More particularly, methods and devices described herein permit creating an ablation pattern on an organ while reducing excessive trauma to a patient.

The invention discloses a construction method, storage medium and computing equipment of sinoatrial node virtual physiological tissue. Firstly, a geometric model of sinoatrial virtual physiological tissue is created; the geometric model is divided into multiple areas, including non-exciting tissue area, central sinus Atrial node tissue area, peripheral sinoatrial node tissue area and atrial tissue area; corresponding cell models were constructed for the divided non-excited tissue, central sinoatrial node tissue, peripheral sinoatrial node tissue and atrial tissue; for the divided Non-excited tissue, central sinus node tissue, peripheral sinus node tissue and atrial tissue were used to construct electrical excitation conduction models. The virtual physiological tissue constructed by the method of the present invention builds a bridge from microscopic molecules to macroscopic organ changes, and the reproduced sinoatrial node pacing and electrical conduction process is more in line with the electrophysiology of the human sinoatrial node, reducing the time and cost of animal experiments. Money spent, faster, better, and safer research on pacing mechanisms in the sinus node.

The invention discloses a method for preparing a decellularized nucleus pulposus material derived from natural tissue. The nucleus pulposus tissue of any size in a mammal is passed through PBS containing protease inhibitors, PBS buffer containing NaCl, and PBS buffer containing Triton X. , PBS buffer containing SDS, and PBS buffer containing DNase to obtain decellularized nucleus pulposus material from natural tissue. The invention can completely decellularize the cells on the tissue with mild conditions, no ECM damage, and rapid stability. The obtained material not only imitates the natural nucleus pulposus structure to the greatest extent, better retains the extracellular matrix components, but also has the advantages of extremely low immunogenicity. It can be used to repair intervertebral disc injuries caused by various etiologies in clinical practice, Diseases associated with degeneration of the nucleus pulposus.

The application relates to a stent valve prosthesis and its delivery system, including a stent, leaflets and clamping parts, the stent includes a support section and a valve sewing section, the proximal end of the support section is connected to the distal end of the valve sewing section, and the leaflet is Connected to the valve sewing segment, the support segment is released and placed on the patient's valve annulus and against the atrial tissue, the clamping part includes one or more side wings, and one end of the clamping part is fixedly connected to the outside of the valve sewing segment On the surface, the clip has three states from compression to complete release. The first state is that the side wings are compressed in the control device; the second state is that the side wings extend along the radial direction of the valve sewing segment and pass through the valve of the adjacent tissue. The junction of the leaflets reaches between the leaflets and the heart wall; the third form is that the wings extend along the circumference of the valve sewing segment and abut against the outer surface of the valve sewing segment. After the release, the patient's tissue leaflets and adjacent chordae are clamped It is held between the side wings and the valve sewing section, which is conducive to improving the anchoring firmness of the valve stent and improving the success rate of the operation.