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30 results about "Atrial tissue" patented technology
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Atrial Tissue Modeling. Different views of simulated atrial fibrillation in 3D model of the human atria. Atrial fibrillation is characterised by multiple excitation waves (seen as the yellow/green regions) that typically propagate as spiral waves or circulate anatomical obstacles such as valves and veins.
Vacuum coagulation probes
InactiveUS7063698B2Surgical instruments for heatingSurgical instruments for aspiration of substancesRadio frequencyArticular cartilage
An embodiment of the invention includes a surgical device for coagulating soft tissue such as atrial tissue in the treatment of atrial fibrillation, atrial flutter, and atrial tachycardia; tendon or ligament shrinkage; or articular cartilage removal. The surgical device integrates a suction mechanism with the coagulation mechanism improving the lesion creation capabilities of the device. The surgical device comprises an elongate member having an insulative covering attached about conductive elements capable of coagulating soft tissue when radiofrequency or direct current energy is transmitted to the conductive elements. Openings through the insulative covering expose regions of the conductive elements and are coupled to lumens in the elongate member which are routed to a vacuum source. Suction causes the soft tissue to actively engage the opening thus the integrated, exposed conductive elements to facilitate the coagulation process and ensure the lesions created are consistent, continuous, and transmural. The embodiments of the invention can also incorporate cooling mechanisms associated with the conductive elements and coupled to a fluid source to passively transport fluid along the contacted soft tissue surface to cool thus pushing the maximum temperature deeper into tissue.
Owner:ATRICURE
Assessment of lesion transmurality
InactiveUS7232437B2Improve visualizationEvenly distributedControlling energy of instrumentCatheterCardiac surfaceLesion formation
A method and apparatus for treating a body tissue in situ (e.g., an atrial tissue of a heart to treat) atrial fibrillation include a lesion formation tool is positioned against the heart surface. The lesion formation tool includes a guide member having a tissue-opposing surface for placement against a heart surface. An ablation member is coupled to the guide member to move in a longitudinal path relative to the guide member. The ablation member has an ablation element for directing ablation energy in an emitting direction away from the tissue-opposing surface. The guide member may be flexible to adjust a shape of the guide member for the longitudinal path to approximate the desired ablation path while maintaining the tissue-opposing surface against the heart surface. In one embodiment, the ablation member includes at least one radiation-emitting member disposed to travel in the longitudinal pathway. Transmurality can be assessed to approximate a location of non-transmurality in a formed lesion.
Owner:ENDOPHOTONIX
Vacuum coagulation probe for atrial fibrillation treatment
InactiveUS6893442B2Surgical instruments for heatingSurgical instruments for aspiration of substancesLess invasiveRadio frequency
An embodiment of the invention includes a surgical device for coagulating soft tissue such as atrial tissue in the treatment of atrial fibrillation, atrial flutter, and atrial tachycardia. The surgical device can include at least one elongate member comprising conductive elements adapted to coagulate soft tissue when radiofrequency or direct current energy is transmitted to the conductive elements. Openings through said conductive elements are routed through lumens in the elongate member to a vacuum source to actively engage the soft tissue surface intended to coagulate into intimate contact with the conductive elements to facilitate the coagulation process and ensure the lesions created are consistent, contiguous, and transmural. The embodiments of the invention can also incorporate cooling openings positioned near the conductive elements and coupled with a vacuum source or an injection source to transport fluid through the cooling openings causing the soft tissue surface to cool thus pushing the maximum temperature deeper into tissue. The embodiments of the invention can also incorporate features to tunnel between anatomic structures or dissect around the desired tissue surface to coagulate thereby enabling less invasive positioning of the soft tissue coagulating device and ensuring reliable and consistent heating of the soft tissue.
Owner:ATRICURE
Method and apparatus for tissue ablation
InactiveUS7250051B2Increase contactSurgical instruments for heatingSurgical forcepsVeinTissue ablation
A method for ablation in which a portion of atrial tissue around the pulmonary veins of the heart is ablated by a first elongated ablation component and a second elongated ablation component movable relative to the first ablation component and having means for magnetically attracting the first and second components toward one another. The magnetic means draw the first and second components toward one another to compress the atrial tissue therebetween, along the length of the first and second components and thereby position the device for ablation of the tissue.
Owner:MEDTRONIC INC
Guided ablation with end-fire fiber
Owner:ENDOPHOTONIX
Vacuum coagulation probe for atrial fibrillation treatment
InactiveUS20060009762A1Surgical instruments for heatingSurgical instruments for aspiration of substancesAnatomical structuresLess invasive
An embodiment of the invention includes a surgical device for coagulating soft tissue such as atrial tissue in the treatment of atrial fibrillation, atrial flutter, and atrial tachycardia. The surgical device can include at least one elongate member comprising conductive elements adapted to coagulate soft tissue when radiofrequency or direct current energy is transmitted to the conductive elements. Openings through said conductive elements are routed through lumens in the elongate member to a vacuum source to actively engage the soft tissue surface intended to coagulate into intimate contact with the conductive elements to facilitate the coagulation process and ensure the lesions created are consistent, contiguous, and transmural. The embodiments of the invention can also incorporate cooling openings positioned near the conductive elements and coupled with a vacuum source or an injection source to transport fluid through the cooling openings causing the soft tissue surface to cool thus pushing the maximum temperature deeper into tissue. The embodiments of the invention can also incorporate features to tunnel between anatomic structures or dissect around the desired tissue surface to coagulate thereby enabling less invasive positioning of the soft tissue coagulating device and ensuring reliable and consistent heating of the soft tissue.
Owner:ATRICURE
Apparatus and method for guided ablation treatment
InactiveUS7238179B2Improve visualizationEvenly distributedControlling energy of instrumentCatheterCardiac surfaceLesion formation
A method and apparatus for forming a lesion in tissue along a desired ablation path with treating a body tissue in situ (e.g., an atrial tissue of a heart to treat) atrial fibrillation include a lesion formation tool including is positioned against the heart surface. The lesion formation tool includes a guide member having a tissue-opposing surface for placement against a heart surface. An ablation member is coupled to the guide member to move in a longitudinal path relative to the guide member. The guide member includes a track. A carriage is slidably received with the track. The ablation member is secured to the carriage for movement therewith. The guide member includes a visualization component.
Owner:ENDOPHOTONIX
Anchored cardiac ablation catheter
An apparatus and method for performing cardiac ablations employs a catheter comprising an anchoring device and an ablating device to perform the ablations to electrically isolate the pulmonary veins and left atrium from surrounding atrial tissue. The anchor can comprise a balloon-type device, a stent-like device, a strut-like device, a spring-strut-like device, an umbrella-like device, a mushroom-like device, or other device that allows the catheter to maintain a position with respect to target tissue. The ablator can comprise a balloon ablator, an umbrella ablator, a pinwheel ablator, an umbrella ablator incorporating a cinch mechanism, a mushroom balloon ablator and a segmented balloon or pinwheel ablator. The anchor and ablator can also comprise a combination mushroom balloon anchor section and mushroom balloon ablator section. The anchor and ablator can include electrodes for measuring a conductance therebetween when in deployed position, so as to determine the effectiveness of the ablation.
Owner:ELECTROPHYSIOLOGY FRONTIERS SPA
Methods of coagulating tissue
InactiveUS20060206113A1Surgical instruments for heatingSurgical instruments for aspiration of substancesRadio frequencyLesion
Owner:ATRICURE
Vacuum coagulation probes
InactiveUS20060200124A1Surgical instruments for heatingSurgical instruments for aspiration of substancesArticular cartilageLesion
An embodiment of the invention includes a surgical device for coagulating soft tissue such as atrial tissue in the treatment of atrial fibrillation, atrial flutter, and atrial tachycardia; tendon or ligament shrinkage; or articular cartilage removal. The surgical device integrates a suction mechanism with the coagulation mechanism improving the lesion creation capabilities of the device. The surgical device comprises an elongate member having an insulative covering attached about conductive elements capable of coagulating soft tissue when radiofrequency or direct current energy is transmitted to the conductive elements. Openings through the insulative covering expose regions of the conductive elements and are coupled to lumens in the elongate member which are routed to a vacuum source. Suction causes the soft tissue to actively engage the opening thus the integrated, exposed conductive elements to facilitate the coagulation process and ensure the lesions created are consistent, continuous, and transmural. The embodiments of the invention can also incorporate cooling mechanisms associated with the conductive elements and coupled to a fluid source to passively transport fluid along the contacted soft tissue surface to cool thus pushing the maximum temperature deeper into tissue.
Owner:ATRICURE
Guided ablation with end-fire fiber
A method and apparatus for treating a body tissue in situ (e.g., an atrial tissue of a heart to treat atrial fibrillation) include a lesion formation tool is positioned against the heart surface. The apparatus includes a guide member having a tissue-opposing surface for placement against a heart surface. The guide member also has interior surfaces and a longitudinal axis. A guide carriage is sized to be received with the guide member and moveable therein along the longitudinal axis. An optical fiber is positioned within the guide carriage with the carriage retaining the fiber. The carriage receives the fiber with an axis substantially parallel to the longitudinal axis and bends the fiber to a distal tip with an axis of said fiber at said distal tip at least 45 degrees to the longitudinal axis and aligned for discharge of laser energy through the tissue opposing surface.
Owner:ENDOPHOTONIX
Methods and devices for modulating atrial configuration
Methods and devices are provided for modulating atrial configuration, e.g., changing the configuration of an atrium, for example by reducing the volume of a left or right atrium. In practicing the subject methods, the configuration of an atrium is modified or changed at least partially without the use of an implant, e.g., through chemical modification and / or application of energy to atrial tissue, where representative energy sources include RF, microwave, laser, ultrasound, cryoablative energy sources, etc. In certain embodiments, the desired atrial configuration modification is achieved by reduction of the atrial volume, e.g., through reduction of the volume of, or constricting / closing the entrance to, the atrial appendage thereof, in a manner sufficient to reduce the volume of the atrium. In certain embodiments, a catheter device comprising an RF source is employed to modulate atrial configuration according to the subject methods. Also provided are devices, systems and kits for use in practicing the subject methods. The subject methods, devices, systems and kits find use in a variety of applications, including reducing the risk of stroke in a subject suffering from atrial fibrillation.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Catheter and Method for Ablation of Atrial Tissue
ActiveUS20070270789A1Easy to adaptUltrasound therapyElectrocardiographyDistal portionBiomedical engineering
Featured is a catheter device for ablating tissue that includes an elongated body member having a distal portion and a deflection mechanism operably coupled to the distal portion so as to cause the distal portion to deflect with respect to a longitudinal axis of the elongated body member. Such a catheter device also includes a guide member and a guiding mechanism that is coupled to the elongated body member and is configured so as to guide the guide member. The guiding mechanism includes an exit portion from which the guide member exits during deployment The exit portion is disposed with respect to the distal portion end so the distal portion deflects from and with respect to the guide member as well as rotating about the guide member. Also featured are systems and methods related thereto.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Anchored cardiac ablation catheter
An apparatus and method for performing cardiac ablations employs a catheter comprising an anchoring device and an ablating device to perform the ablations to electrically isolate the pulmonary veins and left atrium from surrounding atrial tissue. The anchor can comprise a balloon-type device, a stent-like device, a strut-like device, a spring-strut-like device, an umbrella-like device, a mushroom-like device, or other device that allows the catheter to maintain a position with respect to target tissue. The ablator can comprise a balloon ablator, an umbrella ablator, a pinwheel ablator, an umbrella ablator incorporating a cinch mechanism, a mushroom balloon ablator and a segmented balloon or pinwheel ablator. The anchor and ablator can also comprise a combination mushroom balloon anchor section and mushroom balloon ablator section. The anchor and ablator can include electrodes for measuring a conductance therebetween when in deployed position, so as to determine the effectiveness of the ablation.
Owner:ELECTROPHYSIOLOGY FRONTIERS SPA
Anchored cardiac ablation catheter
An apparatus and method for performing cardiac ablations employs a catheter comprising an anchoring device and an ablating device to perform the ablations to electrically isolate the pulmonary veins and left atrium from surrounding atrial tissue. The anchor can comprise a balloon-type device, a stent-like device, a strut-like device, a spring-strut-like device, an umbrella-like device, a mushroom-like device, or other device that allows the catheter to maintain a position with respect to target tissue. The ablator can comprise a balloon ablator, an umbrella ablator, a pinwheel ablator, an umbrella ablator incorporating a cinch mechanism, a mushroom balloon ablator and a segmented balloon or pinwheel ablator. The anchor and ablator can also comprise a combination mushroom balloon anchor section and mushroom balloon ablator section. The anchor and ablator can include electrodes for measuring a conductance therebetween when in deployed position, so as to determine the effectiveness of the ablation.
Owner:ELECTROPHYSIOLOGY FRONTIERS SPA
Apparatus and method for guided ablation treatment
InactiveUS20050182392A1Improve visualizationEvenly distributedControlling energy of instrumentCatheterCardiac surfaceLesion formation
A method and apparatus for treating a body tissue in situ (e.g., an atrial tissue of a heart to treat) atrial fibrillation include a lesion formation tool is positioned against the heart surface. The lesion formation tool includes a guide member having a tissue-opposing surface for placement against a heart surface. An ablation member is coupled to the guide member to move in a longitudinal path relative to the guide member. The ablation member has an ablation element for directing ablation energy in an emitting direction away from the tissue-opposing surface. The guide member may be flexible to adjust a shape of the guide member for the longitudinal path to approximate the desired ablation path while maintaining the tissue-opposing surface against the heart surface. In one embodiment, the ablation member includes at least one radiation-emitting member disposed to travel in the longitudinal pathway. In another embodiment, the guide member has a plurality of longitudinally spaced apart tissue attachment locations with at least two being separately activated at the selection of an operator to be attached and unattached to an opposing tissue surface. Various means are described for the attachment including vacuum and mechanical attachment. The guide member may have a steering mechanism to remotely manipulate the shape of the guide member.
Owner:ENDOPHOTONIX
Assessment of lesion transmurality
InactiveUS20050209589A1Improve visualizationEvenly distributedControlling energy of instrumentCatheterMedicineCardiac surface
A method and apparatus for treating a body tissue in situ (e.g., an atrial tissue of a heart to treat) atrial fibrillation include a lesion formation tool is positioned against the heart surface. The lesion formation tool includes a guide member having a tissue-opposing surface for placement against a heart surface. An ablation member is coupled to the guide member to move in a longitudinal path relative to the guide member. The ablation member has an ablation element for directing ablation energy in an emitting direction away from the tissue-opposing surface. The guide member may be flexible to adjust a shape of the guide member for the longitudinal path to approximate the desired ablation path while maintaining the tissue-opposing surface against the heart surface. In one embodiment, the ablation member includes at least one radiation-emitting member disposed to travel in the longitudinal pathway. Transmurality can be assessed to approximate a location of non-transmurality in a formed lesion.
Owner:ENDOPHOTONIX
Catheter and method for ablation of atrial tissue
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Method and apparatus for tissue ablation
InactiveUS20060195082A1Increase contactSurgical instruments for heatingSurgical forcepsVeinTissue ablation
A method for ablation in which a portion of atrial tissue around the pulmonary veins of the heart is ablated by a first elongated ablation component and a second elongated ablation component movable relative to the first ablation component and having means for magnetically attracting the first and second components toward one another. The magnetic means draw the first and second components toward one another to compress the atrial tissue therebetween, along the length of the first and second components and thereby position the device for ablation of the tissue.
Owner:MEDTRONIC INC
Cooling cannula system and method for use in cardiac surgery
InactiveUS20050038420A1Mitigated and preventedMedical devicesSurgical instrument detailsVenous bloodHeart operations
A novel improved enhanced cardiac surgical method yields unexpected results by having an enhanced intraluminally emplaced cooling system. In preferred device embodiments improvements include a first means for draining venous blood from at least one of the right atrium, superior vena cava and inferior vena cava and an improved means for cooling involved luminal surfaces. Tissue insult and injury is substantially mitigated by engagement of the cooling means with select aspects of involved atrial tissue to augment transfer of heat. In one embodiment of the invention, the right atrium is cooled while the patient's body is maintained at a normothermic temperature during surgery. The alternate cooling mechanisms disclosed have applicability both on- and off-pump in a variety of procedures ranging from traditional open cardiac surgical repair and by-pass to endovascular procedures using percutaneous access and minimally invasive therapies.
Owner:EDWARDS LIFESCIENCES CORP
Stent valve prosthesis and conveying system thereof
ActiveCN109350309AImprove anchoring abilityReduce refluxHeart valvesChordae tendineaeInsertion stent
The invention relates to a stent valve prosthesis and a conveying system thereof. The stent valve prosthesis comprises a stent, valve leaflets and clamping pieces; the stent comprises a support section and a valve leaflet sewing section, the near end of the support section is connected with the far end of the valve leaflet sewing section, the valve leaflets are connected to the valve leaflet sewing section, the support section is placed on the valve leaflets of a patient and abuts against the atrial tissue after being released, and each clamping piece comprises one or multiple side wings, wherein one end of the clamping piece is fixedly connected to the outer surfaces of the valve leaflets, and the clamping piece has three forms from compression to complete releasing in sequence, the firstform is that the side wings are compressed in a control device, the second form is that the side wings stretch in the radial direction of the valve leaflets, penetrate through the valve leaflet junction of adjacent tissues and reach the portion between the valve leaflets and the heart wall, and the third form is that the side wings stretch in the circumferential direction of the valve leaflets and fit the outer surface of the valve leaflet sewing section, after releasing is completed, the tissue valve leaflets of the patient and the adjacent chordae tendineae are clamped between the side wings and the valve leaflet sewing section, the valve leaflet stent anchoring fastness is improved conveniently, and the operative successful rate is increased.
Owner:NINGBO JENSCARE BIOTECHNOLOGY CO LTD
Methods to prevent stress remodeling of atrial tissue
ActiveUS10123836B2Stable supportReduce mechanical stressEndoscopesCatheterLess invasive surgeryTherapeutic treatment
Methods and devices are disclosed herein for therapeutically treating atrial tissue to lessen the effects of mechanical stress on atrial tissue, where reducing mechanical stress in the portion of atrial tissue reduces formation of at least one arrhythmia substrate. In one example, the devices and methods are suitable for minimally invasive surgery. More particularly, methods and devices described herein permit creating an ablation pattern on an organ while reducing excessive trauma to a patient.
Owner:ATRICURE
Method for constructing virtual physiological tissues of sinus node, storage medium and computing device
ActiveCN110310744AShorten the timeConvenient researchMedical simulationSinoatrial nodeElectrophysiology
The invention discloses a method for constructing virtual physiological tissues of a sinus node, a storage medium and a computing device. The method comprises the following steps: creating a geometricmodel for the virtual physiological tissues of a sinus; dividing the geometric model into a plurality of areas including a non-excited tissue area, a central sinus node tissue area, a peripheral sinus node tissue area and an atrium tissue area; respectively constructing corresponding cell models for the non-excited tissues, the central sinus node tissues, the peripheral sinus node tissues and theatrium tissues; and respectively constructing electrical excitation conduction models for the non-excited tissues, the central sinus node tissues, the peripheral sinus node tissues and the atrium tissues obtained after the division. The virtual physiological tissues constructed by the method of the invention construct a bridge for changing from microscopic molecules to macroscopic organ, recurring sinus node pace-making and electrical conduction processes are in line with the electrophysiology of the human sinus node, the time and money cost of animal experiments is reduced, and the pace-making mechanism of the sinus node can be fast, well and safely studied.
Owner:JINAN UNIVERSITY
Construction method, storage medium and computing equipment of sinoatrial node virtual physiological tissue
ActiveCN110310744BConvenient researchSecurity researchMedical simulationElectrophysiologyAv conduction
The invention discloses a construction method, storage medium and computing equipment of sinoatrial node virtual physiological tissue. Firstly, a geometric model of sinoatrial virtual physiological tissue is created; the geometric model is divided into multiple areas, including non-exciting tissue area, central sinus Atrial node tissue area, peripheral sinoatrial node tissue area and atrial tissue area; corresponding cell models were constructed for the divided non-excited tissue, central sinoatrial node tissue, peripheral sinoatrial node tissue and atrial tissue; for the divided Non-excited tissue, central sinus node tissue, peripheral sinus node tissue and atrial tissue were used to construct electrical excitation conduction models. The virtual physiological tissue constructed by the method of the present invention builds a bridge from microscopic molecules to macroscopic organ changes, and the reproduced sinoatrial node pacing and electrical conduction process is more in line with the electrophysiology of the human sinoatrial node, reducing the time and cost of animal experiments. Money spent, faster, better, and safer research on pacing mechanisms in the sinus node.
Owner:JINAN UNIVERSITY
A preparation method of decellularized nucleus pulposus material derived from natural tissue
ActiveCN108310466BEasy to keepMild conditionsTissue regenerationProsthesisCell-Extracellular MatrixECM Protein
The invention discloses a method for preparing a decellularized nucleus pulposus material derived from natural tissue. The nucleus pulposus tissue of any size in a mammal is passed through PBS containing protease inhibitors, PBS buffer containing NaCl, and PBS buffer containing Triton X. , PBS buffer containing SDS, and PBS buffer containing DNase to obtain decellularized nucleus pulposus material from natural tissue. The invention can completely decellularize the cells on the tissue with mild conditions, no ECM damage, and rapid stability. The obtained material not only imitates the natural nucleus pulposus structure to the greatest extent, better retains the extracellular matrix components, but also has the advantages of extremely low immunogenicity. It can be used to repair intervertebral disc injuries caused by various etiologies in clinical practice, Diseases associated with degeneration of the nucleus pulposus.
Owner:ZHEJIANG DISAI BIOTECHNOLOGY CO LTD
Anti-dislocation epicardial atrial pacing electrode
InactiveCN106345052AAvoid the hassle of confusionEasy to operateEpicardial electrodesHeart stimulatorsEngineeringDislocation
The invention relates to an anti-dislocation epicardial atrial pacing electrode used in animal pacing. The electrode is additionally provided with a bendable gasket at a spiral electrode tip in the front end of a wire, and a through hole is formed in a bending area; the electrode tip penetrates through the hole and affixed to the inner side of the bending area of the gasket. The chance and area of contact between the electrode tip and an atrium can be significantly increased by the design of the spiral electrode tip; the gasket can wrap the edge of auricle, so that the contact between the electrode tip and the atrium is promoted, the fall-off phenomenon of the electrode caused by atrial tissue necrosis at a suturing part due to too tight suturing can be effectively avoided, and the ventricular pacing caused by the contact between the electrode and a ventricle can be effectively avoided.
Owner:BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
Atrial cardiac microtissues for chamber-specific arrhythmogenic toxicity responses
PendingUS20220268760A1Improve throughputArtificial cell constructsSkeletal/connective tissue cellsCardiac arrhythmiaRat heart
The invention provides a robust in vitro 3D atrial tissue platform made from human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. The platform is useful for evaluating atrial-specific chemical responses experimentally and computationally.
Owner:BROWN UNIVERSITY +1
Methods for tissue generation
PendingUS20210380950A1Add electric functionSkeletal/connective tissue cellsEmbryonic cellsVentricular tissueRat heart
The present disclosure provides ex vivo chamber-specific cardiac tissues, methods for generating the cardiac tissues in a bioreactor, and methods of using the cardiac tissues. Examples of cardiac tissues that can be generated include, but are not limited to, atrial tissues, ventricular tissues, and composite tissues having an atrial tissue connected to a ventricular tissue.
Owner:RADISIC MILICA
Methods to prevent stress remodeling of atrial tissue
ActiveUS20150250537A1Stable supportReduce mechanical stressEndoscopesCatheterLess invasive surgeryTherapeutic treatment
Methods and devices are disclosed herein for therapeutically treating atrial tissue to lessen the effects of mechanical stress on atrial tissue, where reducing mechanical stress in the portion of atrial tissue reduces formation of at least one arrhythmia substrate. In one example, the devices and methods are suitable for minimally invasive surgery. More particularly, methods and devices described herein permit creating an ablation pattern on an organ while reducing excessive trauma to a patient.
Owner:ATRICURE
A kind of stent valve prosthesis and delivery system thereof
ActiveCN109350309BImprove anchoring abilityReduce refluxHeart valvesChordae tendineaeReoperative surgery
Owner:NINGBO JENSCARE BIOTECHNOLOGY CO LTD
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