Construction method, storage medium and computing equipment of sinoatrial node virtual physiological tissue

Abstract

The invention discloses a construction method, storage medium and computing equipment of sinoatrial node virtual physiological tissue. Firstly, a geometric model of sinoatrial virtual physiological tissue is created; the geometric model is divided into multiple areas, including non-exciting tissue area, central sinus Atrial node tissue area, peripheral sinoatrial node tissue area and atrial tissue area; corresponding cell models were constructed for the divided non-excited tissue, central sinoatrial node tissue, peripheral sinoatrial node tissue and atrial tissue; for the divided Non-excited tissue, central sinus node tissue, peripheral sinus node tissue and atrial tissue were used to construct electrical excitation conduction models. The virtual physiological tissue constructed by the method of the present invention builds a bridge from microscopic molecules to macroscopic organ changes, and the reproduced sinoatrial node pacing and electrical conduction process is more in line with the electrophysiology of the human sinoatrial node, reducing the time and cost of animal experiments. Money spent, faster, better, and safer research on pacing mechanisms in the sinus node.

Description

technical field [0001] The invention relates to the technical field of translational medicine, in particular to a construction method, a storage medium and a computing device of sinoatrial node virtual physiological tissue. Background technique [0002] The sinoatrial node is the pacemaker of the human heart, located in the upper part of the right atrium, near the upper end of the sulcus at the junction of the right atrium and the superior vena cava. The size of the adult sinus node is 15mm×5mm×2mm. The sinoatrial node is flat, surrounded by non-exciting tissue and non-autonomous atrial tissue on the outside, and sinoatrial node cells on the inside. beating cells) and peripheral cells (transition cells). The central cells are small and are the site of cardiac pacing; the peripheral cells are the connecting cells between the central cells and the atrium cells, whose structure and shape are between the central cells and the atrium cells, and are responsible for the conduction...

AI Technical Summary

Problems solved by technology

The following problems exist in the study of the human sinus node: 1) The difference between the current microscopic research and the macroscopic research makes people lack a systematic understanding of the function of the sinus node; 2) Considering ethical issues, there is a lack of human sinus node cells, tissues and structures 3) There are great differences between the sinus nodes of animals and humans, and the availability and reliability of animal experiments on human sinus nodes are limited. dispute

[0005] The prior art document Computational assessment of the functional role of sinoatrial node exit pathways in the human heart (Kharche S R, Vigmond E, Efimov I R, et al. [J]. PloS one, 2017, 12 (9): e0183727.) To the construction method of sinoatrial node tissue, but this method has the following defects: (1) The whole tissue structure includes central sinoatrial node tissue, peripheral sinoatrial node tissue and atrium, and does not contain non-exciting tissues (such as border ridge or fat, etc.) , therefore, the representation of the tissue structure is insufficient; (2) All cells in the tissue adopt the Fenton-Karma calculation model, which is not constructed based on human experimental data and does not have the physiological functions of human cardiomyocytes: the virtual physiological tissue does not contain Calcium clock, atrial model cannot reproduce early afterdepolarization and late afterdepolarization in biological experiments

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